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Protein Overview: plk-1

General Information:
Name(s) found: plk-1 / CE30602 [WormBase]
Description(s) found:
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  • WBGene00004042 locus:plk-1 Serine\/threonine-protein kinase plk-1 status:Confirmed UniProt:P34331 protein_id:CCD64439.1 [WormBase]
  • gi|71981770|ref|NP_001021174.1| POLO Kinase family member (plk-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|3063645|gb|AAC14129.1| putative serine/threonine protein kinase [Caenorhabditis elegans] [NCBI NR]
  • gi|25453449|sp|P34331.3|PLK1_CAEEL RecName: Full=Serine/threonine-protein kinase plk-1; AltName: Full=Polo-like kinase 1 [NCBI NR]
  • ref|NP_741243.1| PoLo Kinase, required for nuclear envelope breakdown and the completion of meiosis (73.6 kD) (plk-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|20451182|gb|AAM22025.1|L15188_6 Polo kinase protein 1, isoform b, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • Serine/threonine-protein kinase plk-1 OS=Caenorhabditis elegans GN=plk-1 PE=1 SV=3 [Swiss-Prot]
  • [wormpep79.fasta]
  • CE30602 WBGene00004042 locus:plk-1 status:Confirmed SW:P34331 protein_id:AAM22025.1 [wormpep150.fasta]
  • 30602 WBGene00004042 locus:plk-1 status:Confirmed SW:P34331 protein_id:AAM22025.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • PoLo Kinase, required for nuclear envelope breakdown and the completion of meiosis (73.6 kD) (plk-1) [Caenorhabditis elegans]gi|20451182|gb|AAM22025.1| Polo kinase protein 1, isoform b [Caenorhabditis elegans]gi|3063645|gb|AAC14129.1| putative serine/th [nrdb_11152004_Chlamydomonas]
  • locus:plk-1 status:Confirmed SW:P34331 protein_id:AAM22025.1 [wormpep115.fasta.reversed]
  • CE30602 locus:plk-1 status:Confirmed [wormpep80.hongbin]
  • CE30602 WBGene00004042 locus:plk-1 status:Confirmed UniProt:PLK1_CAEEL protein_id:AAM22025.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE30602 WBGene00004042 locus:plk-1 status:Confirmed UniProt:PLK1_CAEEL protein_id:AAM22025.1| [wormORF-contam.fasta]
  • Serine/threonine-protein kinase plk-1 (Polo-like kinase 1) [nr-271106-contam.fasta]
  • putative serine/threonine protein kinase [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • POLO Kinase family member (plk-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Polo kinase protein 1, isoform b [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE30602 WBGene00004042 locus:plk-1 status:Confirmed UniProt:P34331 protein_id:AAM22025.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE30602 WBGene00004042 locus:plk-1 status:Confirmed UniProt:P34331 protein_id:CCD64439.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE30602 WBGene00004042 locus:plk-1 status:Confirmed UniProt:P34331 protein_id:CCD64439.1 Serine\/threonine-protein kinase plk-1 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 649 amino acids

    Gene Ontology:
    Cellular Component: centrosome [IDALink to PubMed article]
    Biological Process: polar body extrusion after meiotic divisions [IMPLink to PubMed article]
    embryonic cleavage [IMPLink to PubMed article]
    hermaphrodite genitalia development [IMPLink to PubMed articleLink to PubMed article]
    mitotic nuclear envelope disassembly [TASLink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    determination of adult lifespan [IMPLink to PubMed article]
    meiotic chromosome segregation [IMPLink to PubMed article]
    cytokinesis [IMPLink to PubMed article]
    protein amino acid phosphorylation [IEALink to PubMed article]
    reproduction [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: magnesium ion binding [IEALink to PubMed article]
    ATP binding [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    protein binding [IEALink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRLPNIAKP PQKSNQRKEK APPEVPALIA DKDRGTYYEK GRFLGKGGFA HCYELTNRAT  60
   61 REVVAGKVVP KSMLVKQYQR DKVDNERILI HRELGHINIV KLFNFFEDNL NVYITLELCA 120
  121 RRSLMELHKR RKAVTEPEAR YFTHQIVDGV LYLHDLNIIH RDMKLGNLFL NDDLVVKIGD 180
  181 FGLATTVNGD ERKKTLCGTP NYIAPEVLNK AGHSFEVDIW AVGCILYILL FGQPPFESKS 240
  241 LEETYSRIRH NNYTIPSIAT QPAASLIRKM LDPEPTRRPT AKQVQRDGFF KSGFMPTRLP 300
  301 VSCLTMVPKF GGHETSMMEE NVAPRGVDAR SQRPLNGRAG LSALPQHIVS NNADRERAQQ 360
  361 QAAEATFREP EDAYLSQLFH QVAVLLEQRI PGLEEEEAAL DGYQSPECLP VFWISKWVDY 420
  421 SDKYGIGYQL CDNSVGVLFN DNSRIMLDQA GNELTYIEKS NKEHYFSMHS GEMPGLLNKK 480
  481 VTLLKYFRSY MNDHLVKAGE GSEQRAGDDL ARLPTLRVWF RTKSAIVLHL SNGTVQINFF 540
  541 NDHVKMMMCP LMQAVTFIDQ NKRMLTYKLN NLQRNGCPEK FLHRLKYAKT MIERLMSDAN 600
  601 VVSQNPARQP DMPRSMAAAR SASAGSRGPN QAASHLPQSA SGSNIHPRR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..342] PSI-BLAST 64.154902 No description for 2ou7A was found.
    2 View Details [343..649] PSI-BLAST 54.522879 The polo-box domain of Plk1 in complex with a phospho-peptide


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle