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Protein Overview: gap-2

General Information:
Name(s) found: gap-2 / CE28277 [WormBase]
Description(s) found:
Found 15 descriptions.
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  • WBGene00001516 locus:gap-2 Ras GTPase-activating protein gap-2 status:Confirmed UniProt:Q8MLZ5 protein_id:CAA86414.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 787 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEALink to PubMed article]
    Biological Process: regulation of small GTPase mediated signal transduction [IEALink to PubMed article]
    reproduction [IMPLink to PubMed article]
    Molecular Function: GTPase activator activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRGEYDPWDP SFHNSSMIPY SLASIYPSIE NLPEEFSNEN NKIKNVLKNF IWSFKLKKNY  60
   61 VRVSSLFGEY TVNTSHSDSG TSRIASALGG KSSSQESPSL RIKARWQSVH ILPLRAYDNL 120
  121 LETLCYNYLP LCEQLEPVLN VRDKEDLATS LVRVMYKHNL AKEFLCDLIM KEVEKLDNDH 180
  181 LMFRGNTLAT KAMESFMKLV ADDYLDSTLS DFIKTVLQCE DSCEVDPQKL GNVSNSSLEK 240
  241 NRALLMRYVE VAWTKILNNV HQLPKNLRDV FSALRCRLEA QNREALADTL ISSSIFLRFL 300
  301 CPAILSPSLF NLVSEYPSPT NARNLTLIAK TLQNLANFSK FGGKEPHMEF MNEFVDREWH 360
  361 RMKDFLLRIS SESKSGPEKN ADAIVDAGKE LSLIATYLEE AWTPLLQEKN GNKHPLSNVK 420
  421 SVLSELAECK RRSDNGVFHS PMVQQPSSDY ENSPQQHVVP RHENVPAYRS TPPTGQATVL 480
  481 GRSTNRPATH LLTSDDYVLS SAFQTPSLRP GGTRLSDETG TSSSRTSDKT TSSAEIRDDT 540
  541 DSDFELREDR GRGGRNRKRL PRTDASPSSS QQASSGYLSN NPSRSSYSNS SSSSPVERMA 600
  601 ALSIANPVFG PGPSSGYAIP AEPKEIVYQK RASPPPYDPD VHNYHYQPMQ VYAVPPDCQV 660
  661 SPRTQATGGV NAQNRLSLPR TNPRASRNST LLRPSVVNVP DDWDRTSDYW RDRGENNYRS 720
  721 QLESQVESQA REIERLMREN IELKSKMMSS TKTVDSKRSD SGASEDSYDS LSSLDRPSRQ 780
  781 SLVVVPN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..108] PSI-BLAST 5.0 No description for 2nsqA was found.
    2 View Details [109..425] PSI-BLAST 76.30103 RAS-GTPASE-ACTIVATING DOMAIN OF HUMAN P120GAP
    3 View Details [426..484] deduced N/A No confident structure predictions are available.
    4 View Details [485..706] PSI-BLAST 3.69897 No description for 1y0fB was found.
    5 View Details [707..787] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • enzyme regulator activity
    		•  0.68732227880003 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.590837939249671 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.59070509814251 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.53004209819211 bayes_pls_golite062009
  • GTPase activator activity
    		•  0.528693496432149 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  0.10243777232979 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  0.0454578418356197 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle