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View Structure Prediction Details

Protein: gap-2
Organism: Caenorhabditis elegans
Length: 787 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gap-2.

Description E-value Query
Range
Subject
Range
gap-2 - status:Confirmed UniProt:Q3S1K5 protein_id:CAJ30221.1
637.0 [0..2] [787..50]

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Predicted Domain #1
Region A:
Residues: [1-108]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRGEYDPWDP SFHNSSMIPY SLASIYPSIE NLPEEFSNEN NKIKNVLKNF IWSFKLKKNY  60
   61 VRVSSLFGEY TVNTSHSDSG TSRIASALGG KSSSQESPSL RIKARWQS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.0
Match: 2nsqA
Description: No description for 2nsqA was found.

Predicted Domain #2
Region A:
Residues: [109-425]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VHILPLRAYD NLLETLCYNY LPLCEQLEPV LNVRDKEDLA TSLVRVMYKH NLAKEFLCDL  60
   61 IMKEVEKLDN DHLMFRGNTL ATKAMESFMK LVADDYLDST LSDFIKTVLQ CEDSCEVDPQ 120
  121 KLGNVSNSSL EKNRALLMRY VEVAWTKILN NVHQLPKNLR DVFSALRCRL EAQNREALAD 180
  181 TLISSSIFLR FLCPAILSPS LFNLVSEYPS PTNARNLTLI AKTLQNLANF SKFGGKEPHM 240
  241 EFMNEFVDRE WHRMKDFLLR ISSESKSGPE KNADAIVDAG KELSLIATYL EEAWTPLLQE 300
  301 KNGNKHPLSN VKSVLSE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 76.30103
Match: 1werA
Description: RAS-GTPASE-ACTIVATING DOMAIN OF HUMAN P120GAP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
enzyme regulator activity 0.68732227880003 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.590837939249671 bayes_pls_golite062009
GTPase regulator activity 0.59070509814251 bayes_pls_golite062009
enzyme activator activity 0.53004209819211 bayes_pls_golite062009
GTPase activator activity 0.528693496432149 bayes_pls_golite062009
small GTPase regulator activity 0.10243777232979 bayes_pls_golite062009
Ras GTPase activator activity 0.0454578418356197 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [426-484]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LAECKRRSDN GVFHSPMVQQ PSSDYENSPQ QHVVPRHENV PAYRSTPPTG QATVLGRST

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [485-706]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NRPATHLLTS DDYVLSSAFQ TPSLRPGGTR LSDETGTSSS RTSDKTTSSA EIRDDTDSDF  60
   61 ELREDRGRGG RNRKRLPRTD ASPSSSQQAS SGYLSNNPSR SSYSNSSSSS PVERMAALSI 120
  121 ANPVFGPGPS SGYAIPAEPK EIVYQKRASP PPYDPDVHNY HYQPMQVYAV PPDCQVSPRT 180
  181 QATGGVNAQN RLSLPRTNPR ASRNSTLLRP SVVNVPDDWD RT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.69897
Match: 1y0fB
Description: No description for 1y0fB was found.

Predicted Domain #5
Region A:
Residues: [707-787]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDYWRDRGEN NYRSQLESQV ESQAREIERL MRENIELKSK MMSSTKTVDS KRSDSGASED  60
   61 SYDSLSSLDR PSRQSLVVVP N

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle