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Protein Overview: unc-43

General Information:
Name(s) found: unc-43 / CE28056 [WormBase]
Description(s) found:
Found 22 descriptions.
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  • WBGene00006779 locus:unc-43 Calcium\/calmodulin-dependent protein kinase type II status:Confirmed UniProt:O62305 protein_id:CAC42327.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 518 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: protein amino acid phosphorylation [IEALink to PubMed article]
    Molecular Function: magnesium ion binding [IEALink to PubMed article]
    ATP binding [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMNASTKFSD NYDVKEELGK GAFSVVRRCV HKTTGLEFAA KIINTKKLSA RDFQKLEREA  60
   61 RICRKLQHPN IVRLHDSIQE ESFHYLVFDL VTGGELFEDI VAREFYSEAD ASHCIQQILE 120
  121 SIAYCHSNGI VHRDLKPENL LLASKAKGAA VKLADFGLAI EVNDSEAWHG FAGTPGYLSP 180
  181 EVLKKDPYSK PVDIWACGVI LYILLVGYPP FWDEDQHRLY AQIKAGAYDY PSPEWDTVTP 240
  241 EAKSLIDSML TVNPKKRITA DQALKVPWIC NRERVASAIH RQDTVDCLKK FNARRKLKGA 300
  301 ILTTMIATRN LSSRNLLNKK EQGPPSTIKE SSESSQTIDD NDSEKGGGQL KHENTVVRAD 360
  361 GATGIVSSSN SSTASKSSST NLSAQKQDIV RVTQTLLDAI SCKDFETYTR LCDTSMTCFE 420
  421 PEALGNLIEG IEFHRFYFDG NRKNQVHTTM LNPNVHIIGE DAACVAYVKL TQFLDRNGEA 480
  481 HTRQSQESRV WSKKQGRWVC VHVHRSTQPS TNTTVSEF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-2 hcp2 ip from december Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..363] PSI-BLAST 88.0 Crystal Structure of the Auto-Inhibited Kinase Domain of Calcium/Calmodulin Activated Kinase II
    2 View Details [364..518] PSI-BLAST 42.522879 The Association Domain of C. elegans CaMKII


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.78

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle