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Protein Overview: itr-1

General Information:
Name(s) found: itr-1 / CE28018 [WormBase]
Description(s) found:
Found 22 descriptions.
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  • WBGene00002173 locus:itr-1 Inositol 1,4,5-trisphosphate receptor itr-1 status:Partially_confirmed UniProt:Q9Y0A1 protein_id:CCD63766.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 2846 amino acids

    Gene Ontology:
    Cellular Component: membrane [IDALink to PubMed article][IEALink to PubMed article]
    endoplasmic reticulum [TASLink to PubMed article]
    proteinaceous extracellular matrix [IEALink to PubMed article]
    Biological Process: regulation of pharyngeal pumping [IGILink to PubMed article][IMPLink to PubMed article]
    ion transport [IEALink to PubMed article]
    muscle contraction [IMPLink to PubMed article]
    calcium ion transport [IEALink to PubMed article]
    cell adhesion [IEALink to PubMed article]
    blood coagulation [IEALink to PubMed article]
    defecation [IMPLink to PubMed article]
    reproduction [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    rhythmic behavior [IMPLink to PubMed article]
    elevation of cytosolic calcium ion concentration [IDALink to PubMed article]
    Molecular Function: inositol-1,4,5-trisphosphate receptor activity [ISSLink to PubMed article]
    ion channel activity [IEALink to PubMed article]
    calcium channel activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDYDYRRRVL ERNIGMALPS RKLTIANSID HGNNGNLHIG DIISLYTESS SNQEQRGFLS  60
   61 TLGLVDDRCI VELKDGRPES PPKKFRDCLF KVCPVNRYAA QKHLWTEQKR FQTGDSMFDD 120
  121 DLMNKLKVAA DKEREENESE FQKTLGNVIQ YGSMVQLLHV KSNKYITVQK NSPAKRERNA 180
  181 MKVYLDRAGN EGSWFIIEPA YKHYAIGDNV SAGNKISLIP NSVSTTQAGH VKSQLHLSSF 240
  241 NLLDHQSAAE VNCLNEPTEW QVFMFLLFDE NQQNSVKSGD VVRLFHADQQ TFLTLDTIPK 300
  301 QNPPTDVVFL RMTNRPSAAD ATSSRALWEV QVVQTNAYRG GTAKWNKAYR FKHLATDMYL 360
  361 SAEPSQVQVK PAMNGRRASL IYSKTNNPMA MYSDGPNGVT NESTDTTQQN IPSVWVLGPT 420
  421 KSEFPEEDAN LLFQLDPSTF MKSNKEVPRR SYVRLLHQSS DKWVHATNAT EKQNLHYSSK 480
  481 NEKGWVKVIC EKNRVDKETF ALLPVNPDEV RDLDFANDAC KALRNFIKLI KIGQVISKES 540
  541 INSTTQLLID CILFVTNSSD HLADPLKISD FSPSRDRQKL LREQEVLNQV FLLLKAPFLP 600
  601 RQGTTELGPL LSSPSELSDS RNEIFKTMFQ LCYCLLKYSQ VSYRKNQEFL AEKFGEIQEQ 660
  661 IGFDLMAEDT MTAVLHNNPK LLEKYVKTPH VERFVELVRN NRQGKFLDYL ADLCVCRGEA 720
  721 NKKIQELICT SVLSSKHRDI FMDTKIIDGE IEVGWAPNFR KLVDIAEGAK SNSDDAEHLD 780
  781 YYRHQLDLLS QMCQEQQYLA IDPPPERRLM NISQQLPAEL VLQCMSDNRL PYDLRGSFTR 840
  841 LMLHLHVVRG SPMSAIRHAR LWWSIPENVN VSTYESVSVE AYSDGSRMRI GEGIAHKVLA 900
  901 TVETYLMGLR NQSMEERQSV NSSKLTYEIV NLAKALAQFN FYSFNDLLQL TQNLLAIINE 960
  961 GPATEQVPSH RAMVNAIRNM SKSMMRGGNK ENSKDLAKTP SVTAEEAGRT KEGRALNVKT1020
 1021 KLIVAEILQF VMDVRRDYRI TMALSWFKNV FPCDEDGSLM HSASINERMA SELYDAIYRS1080
 1081 SGHELHLDGR DGQLLLAILL QMTMSDYPPL TSIALKVFFR HFTQYQELLE DLKQVQLLVS1140
 1141 NNDVENYRQI DRDLFILKNL TEKSELWVHG DRHHSIDTKE VDEKERTTEH DLLDHDLKSP1200
 1201 RAFDSGDSME ALMAVLNEHY PSIRNECLQL LNRLLIKDDR NDAAVALQEL SDKAPLIAYP1260
 1261 LIRQMLVRLT GMCYRKGDPK PDTMNQQLLK NMRVYEVVLE FISVPHDKKH DHDMMKLITL1320
 1321 SHEFLRSFCK TNKENQSRLY KFISYEKDAK EGMLRVETIE EVGTLVAIFR NNRELASNVP1380
 1381 EELIAHIVGL IEHNSRNPIF LELLQALVCV YDKEIESGQE KVANEICAAS DEVRQLYVDN1440
 1441 ASFEELEAMM KDEKESKGRS SDSRRKLKYH IELVRLLAMC TRGKNGNTEL KCASQIPMDH1500
 1501 IVRVVTAKQC LVEVKTVYLQ LLLHCYIDTD AEMKDAYKTE YVDHILNNLL EDIRSLRVEK1560
 1561 LTGAETATLE HYICHTVTEV LIKFFEAPYS ALQQAKVDVH HHKKTFSEVL LELTYLEKGK1620
 1621 LRGSKSSRNW YRVAECIKRL TKWAEEHNIT LPATLAGPQM SGQTSVRQKW QQAASSAKWI1680
 1681 GIGKRLNRQN TLNPGHRLYG TSNSMTEHTS ANVVTCYHMM IGEFKFYLHP LHAAEGSVLV1740
 1741 EVLHTPELLF PEGSALRDQC ARGGVVAKLI QHCKTLMQNK QDNLCARVLQ TLCKMCDCTK1800
 1801 QQLTHQGQQL RQLLLQRYFG HHNNHHPPLD RQQSKIGEVI EAVKEKKEET WSQERDLYAI1860
 1861 QCKLNDAGAS DLVTDIIIME PSREIFLKAI HLARALLHEG NDKVQHSFYM RMKQKDIHEP1920
 1921 FFKAILTRIQ TAQNRLKSDM MSCSDSKPKV SLSATVSRRS STVLTPLIDA GDTGFNGALF1980
 1981 EVPQQVRHPS ISEMSQLSND LTHSIPDLAP YQDEEKSTDA LPPEVALVEP ILRVLQLLCE2040
 2041 NHNSLLQNFL RKQSDRTNHN LVSETLSFLD TVCGSTKGSL GVFGEIGEHN FSLITQTLAT2100
 2101 LTEFCQGPCH ENQNTMAMQE NGLNIIISLV LNEIKPLADD HMELALEIKS QASKLLLAIM2160
 2161 ESRHDGENAN RVLRNMANMS GGPKQLVHAI KQAYEMTNSN HHMLKSISRD LFRQAEDDLK2220
 2221 KKSGPQITVN TVTLPEINVD ASGIVSIHTE KNISSSLDDK FNDDDIPSVD PREVGHNIYI2280
 2281 LAHQLAIHDG ELEIWLDGSD EKKDDLTREA LNYYKERTAQ IEIVRRDRTL ERVVFPINDI2340
 2341 CSYLTKDTKD YVYNNTERDN QGSKVTEFFD EWETMYHEMI WQRKLQDRKW LSWCAFRLPL2400
 2401 WTRLSFHFAF IVNALVARYY PLPEHSNSSI SLGNLYSWFA VFSSFLLAHY LRHDKIYLHK2460
 2461 TSLLILASLC FLLLSSIGVT LTLYIFGILQ LVNKIVHVVA FVSNKGLEDR PIAEILACRN2520
 2521 LHYLLVYLFI CILGLLVHPM IYCILLFDII FTEETLQNVI ASVTRNYQSI VWTGLLALIL2580
 2581 LYFFSILGFL YFRHDFYLEV DPVENDSSAT ISSGIPSETC PSEGCPGLQP SEKDDNDDEK2640
 2641 KVKSCETLWM CILQTGYQGL RNGGGIGDVL RNPAPWEDMF IWRVAYDMTF FVVLIVIVLN2700
 2701 LIFGVIIDTF GDLRAEKNEK EQILKNNCFI CGLDRSRFDN RSVTFETHRE TEHNIWHYLY2760
 2761 YIVMLQIKDE TEFTGPESYV AQCVKDRNLD WFPRMQALSL QDSELDTDQS EVKQMKDQLL2820
 2821 QMMTLMREII SQNEESRAFM EQFQPR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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