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Protein Overview: vhp-1

General Information:
Name(s) found: vhp-1 / CE27918 [WormBase]
Description(s) found:
Found 24 descriptions.
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  • WBGene00006923 locus:vhp-1 Tyrosine-protein phosphatase vhp-1 status:Confirmed UniProt:Q10038 protein_id:CCD68973.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 657 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISSLink to PubMed article]
    cytoplasm [ISSLink to PubMed article]
    Biological Process: inactivation of MAPK activity [IDALink to PubMed article][IGILink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    morphogenesis of an epithelium [IMPLink to PubMed article]
    protein amino acid dephosphorylation [IDALink to PubMed article][IEALink to PubMed article]
    response to copper ion [IGILink to PubMed article]
    negative regulation of JNK cascade [IDALink to PubMed article]
    dephosphorylation [IEALink to PubMed article]
    positive regulation of locomotion [IMPLink to PubMed article]
    Molecular Function: protein tyrosine phosphatase activity [IEALink to PubMed article]
    phosphatase activity [IEALink to PubMed article]
    JUN kinase phosphatase activity [IDALink to PubMed article]
    MAP kinase tyrosine/serine/threonine phosphatase activity [IDALink to PubMed article]
    protein tyrosine/serine/threonine phosphatase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTVLDTVTIS TCGLAALIRE APDTTLVVDC RGFTEYNESH VRHSMNAFFS KLIRRRLFEN  60
   61 KLDDNCLIHQ LMSCSSGCTK MDEKLDLVLY AEEDKPRGNK RRIASCNAPE STAKIMRVLR 120
  121 ERLEDTDKFR SVMVLEGGFK QFAQQYPQLC ESSEGMTRLP QSLSQPCLSQ PTGDGITLIT 180
  181 PNIYLGSQID SLDETMLDAL DISVVINLSM TCPKSVCIKE DKNFMRIPVN DSYQEKLSPY 240
  241 FPMAYEFLEK CRRAGKKCLI HCLAGISRSP TLAISYIMRY MKMGSDDAYR YVKERRPSIS 300
  301 PNFNFMGQLL EYENVLIKDH VLDYNQASRP HRHMDYYGPS DLCPPKVPKS ASSNCVFPGS 360
  361 THDESSPSSP SVSEGSAASE PETSSSAASS SSTASAPPSM PSTSEQGTSS GTVNVNGKRN 420
  421 MTMDLGLPHR PKALGLPSRI GTSVAELPSP STELSRLSFN GPEAIAPSTP ILNFTNPCFN 480
  481 SPIIPVASSS REVILTLPTP AASSSSSTSS EPSFDFSSFE SSSSSSIVVE NPFFASTEVP 540
  541 AGSSSISTPS GSQSTPASAS SSAASRCRMK GFFKVFSKKA PASTSTPASS TPGTSRAARP 600
  601 ECLRSSGIII SAPVLAITEE EDAESPESGF NEPEVGEEDD DSVSICSTSS LEIPCHQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..171] PSI-BLAST 32.0 Erk2 binding domain of Mapk phosphatase mkp-3
    2 View Details [172..383] PSI-BLAST 41.39794 No description for 2g6zA was found.
    3 View Details [384..521] MSA 1.227996 View MSA. No confident structure predictions are available.
    4 View Details [522..657] MSA 4.217995 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  4.79074052803751 bayes_pls_golite062009
  • phosphatase activity
    		•  4.46276380920308 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  4.26891308022499 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  3.37977783690618 bayes_pls_golite062009
  • protein tyrosine phosphatase activity
    		•  2.84204105189999 bayes_pls_golite062009
  • hydrolase activity
    		•  2.12055507229256 bayes_pls_golite062009
  • binding
    		•  1.72957395505299 bayes_pls_golite062009
  • protein binding
    		•  1.56606332199727 bayes_pls_golite062009
  • transferase activity
    		•  1.00600613068372 bayes_pls_golite062009
  • catalytic activity
    		•  0.687308230067573 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.91

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle