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Protein Overview: plk-1

General Information:
Name(s) found: plk-1 / CE26649 [WormBase]
Description(s) found:
Found 22 descriptions.
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  • WBGene00004042 locus:plk-1 Serine\/threonine-protein kinase plk-1 status:Confirmed UniProt:P34331 protein_id:CCD64438.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 648 amino acids

    Gene Ontology:
    Cellular Component: centrosome [IDALink to PubMed article]
    Biological Process: polar body extrusion after meiotic divisions [IMPLink to PubMed article]
    embryonic cleavage [IMPLink to PubMed article]
    hermaphrodite genitalia development [IMPLink to PubMed articleLink to PubMed article]
    mitotic nuclear envelope disassembly [TASLink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    determination of adult lifespan [IMPLink to PubMed article]
    meiotic chromosome segregation [IMPLink to PubMed article]
    cytokinesis [IMPLink to PubMed article]
    protein amino acid phosphorylation [IEALink to PubMed article]
    reproduction [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: magnesium ion binding [IEALink to PubMed article]
    ATP binding [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    protein binding [IEALink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRLPNIAKP PQKSNQRKEK APPEVPALIA DKDRGTYYEK GRFLGKGGFA HCYELTNRAT  60
   61 REVVAGKVVP KSMLVKQYQR DKMTQEVQIH RELGHINIVK LFNFFEDNLN VYITLELCAR 120
  121 RSLMELHKRR KAVTEPEARY FTHQIVDGVL YLHDLNIIHR DMKLGNLFLN DDLVVKIGDF 180
  181 GLATTVNGDE RKKTLCGTPN YIAPEVLNKA GHSFEVDIWA VGCILYILLF GQPPFESKSL 240
  241 EETYSRIRHN NYTIPSIATQ PAASLIRKML DPEPTRRPTA KQVQRDGFFK SGFMPTRLPV 300
  301 SCLTMVPKFG GHETSMMEEN VAPRGVDARS QRPLNGRAGL SALPQHIVSN NADRERAQQQ 360
  361 AAEATFREPE DAYLSQLFHQ VAVLLEQRIP GLEEEEAALD GYQSPECLPV FWISKWVDYS 420
  421 DKYGIGYQLC DNSVGVLFND NSRIMLDQAG NELTYIEKSN KEHYFSMHSG EMPGLLNKKV 480
  481 TLLKYFRSYM NDHLVKAGEG SEQRAGDDLA RLPTLRVWFR TKSAIVLHLS NGTVQINFFN 540
  541 DHVKMMMCPL MQAVTFIDQN KRMLTYKLNN LQRNGCPEKF LHRLKYAKTM IERLMSDANV 600
  601 VSQNPARQPD MPRSMAAARS ASAGSRGPNQ AASHLPQSAS GSNIHPRR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..346] PSI-BLAST 64.30103 No description for 2ou7A was found.
    2 View Details [347..648] PSI-BLAST 53.69897 The polo-box domain of Plk1 in complex with a phospho-peptide


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle