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Protein Overview: dbl-1

General Information:
Name(s) found: dbl-1 / CE26386 [WormBase]
Description(s) found:
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  • WBGene00000936 locus:dbl-1 status:Confirmed UniProt:G5EEL5 protein_id:CCD74236.1 [WormBase]
  • gi|3347813|gb|AAC27729.1| decapentaplegic protein homolog [Caenorhabditis elegans] [NCBI NR]
  • gi|21106034|gb|AAB04986.2| Dpp/bmp-like protein 1 [Caenorhabditis elegans] [NCBI NR]
  • gi|17559164|ref|NP_504709.1| DPP/BMP-Like family member (dbl-1) [Caenorhabditis elegans] [NCBI NR]
  • [wormpep67.fasta]
  • CE26386 WBGene00000936 locus:dbl-1 TGF-beta-like growth factor status:Confirmed TR:O02424 protein_id:AAB04986.2 [wormpep150.fasta]
  • 26386 WBGene00000936 locus:dbl-1 TGF-beta-like growth factor status:Confirmed TR:O02424 protein_id:AAB04986.2 [wormpep130-phg-ecoli-orf-rand.fasta]
  • decapentaplegic / Bone morphogenetic protein Like, transforming growth factor-beta homolog, regulator of body size and male tail differentiation (41.7 kD) (dbl-1) [Caenorhabditis elegans]gi|21106034|gb|AAB04986.2| Dpp/bmp-like protein 1 [Caenorhabditis e [nrdb_11152004_Chlamydomonas]
  • locus:dbl-1 TGF-beta-like growth factor status:Confirmed TR:O02424 protein_id:AAB04986.2 [wormpep115.fasta.reversed]
  • CE26386 locus:dbl-1 TGF-beta-like growth factor status:Confirmed [wormpep80.hongbin]
  • CE26386 WBGene00000936 locus:dbl-1 TGF-beta-like growth factor status:Confirmed UniProt:O02424_CAEEL protein_id:AAB04986.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE26386 WBGene00000936 locus:dbl-1 TGF-beta-like growth factor status:Confirmed UniProt:O02424_CAEEL protein_id:AAB04986.2| [wormORF-contam.fasta]
  • DPP/BMP-Like family member (dbl-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • decapentaplegic protein homolog [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Dpp/bmp-like protein 1 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE26386 WBGene00000936 locus:dbl-1 TGF-beta-like growth factor status:Confirmed UniProt:O02424 protein_id:AAB04986.2 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE26386 WBGene00000936 locus:dbl-1 TGF-beta-like growth factor status:Confirmed UniProt:G5EEL5 protein_id:CCD74236.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE26386 WBGene00000936 locus:dbl-1 status:Confirmed UniProt:G5EEL5 protein_id:CCD74236.1 [wormpep246-ecoli-contam.fasta]
  • DPP/BMP-Like OS=Caenorhabditis elegans GN=dbl-1 PE=2 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 365 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [IEALink to PubMed article]
    Biological Process: positive regulation of cell size [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    positive regulation of organ growth [IMPLink to PubMed article]
    tail tip morphogenesis [IMPLink to PubMed article]
    positive regulation of multicellular organism growth [IGILink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    Molecular Function: growth factor activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNDSVRTTTT ISSTKSLVHS FQLSAILHLF LLISFTPMSA AADQHASHAT RRGLLRKLGL  60
   61 EHVPVQTGPS IDVPQHMWDI YDDDNDVDWV RHYYPKEIIE DNEGFLLSYN LSLAARNAHN 120
  121 EEVTKATLKL RLRRNNKARR SGNISIYFFE DDINNDRFQI ESRSVDNLTE WIDFDVTAAF 180
  181 LRRTNRISFF IDLPEDVEIE ETQSSSLSSL PYARAQSAPL IVFSDLSEPS SVRRKRSAQT 240
  241 GNSERKNRKK GRKHHNTEAE SNLCRRTDFY VDFDDLNWQD WIMAPKGYDA YQCQGSCPNP 300
  301 MPAQLNATNH AIIQSLLHSL RPDEVPPPCC VPTETSPLSI LYMDVDKVIV IREYADMRVE 360
  361 SCGCR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..114] MSA 12.302997 View MSA. No confident structure predictions are available.
    2 View Details [115..224] deduced N/A No confident structure predictions are available.
    3 View Details [225..365] PSI-BLAST 40.0 BONE MORPHOGENETIC PROTEIN-7

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • receptor binding
    		•  4.70889547404918 bayes_pls_golite062009
  • cytokine activity
    		•  3.61376517935324 bayes_pls_golite062009
  • growth factor activity
    		•  3.55277889903829 bayes_pls_golite062009
  • platelet-derived growth factor binding
    		•  3.43601005070198 bayes_pls_golite062009
  • protein binding
    		•  3.16282476674164 bayes_pls_golite062009
  • cell surface binding
    		•  2.9725198156666 bayes_pls_golite062009
  • binding
    		•  2.37954321554411 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  2.01478614969692 bayes_pls_golite062009
  • vascular endothelial growth factor receptor 1 binding
    		•  1.87722086999547 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  1.87074199164241 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  1.87074199164241 bayes_pls_golite062009
  • type II transforming growth factor beta receptor binding
    		•  1.74489645820593 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  1.67879530820663 bayes_pls_golite062009
  • collagen binding
    		•  1.64555624988816 bayes_pls_golite062009
  • protein dimerization activity
    		•  1.44846386076063 bayes_pls_golite062009
  • vascular endothelial growth factor receptor 2 binding
    		•  1.44790236067538 bayes_pls_golite062009
  • vascular endothelial growth factor receptor binding
    		•  1.43930353468665 bayes_pls_golite062009
  • hormone activity
    		•  1.39628583804208 bayes_pls_golite062009
  • heparin binding
    		•  1.30997160523692 bayes_pls_golite062009
  • growth factor binding
    		•  1.28535209856904 bayes_pls_golite062009
  • glial cell line-derived neurotrophic factor receptor binding
    		•  1.16821412683065 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.16191864095271 bayes_pls_golite062009
  • protein homodimerization activity
    		•  1.13743310822539 bayes_pls_golite062009
  • platelet-derived growth factor receptor binding
    		•  1.12951786832285 bayes_pls_golite062009
  • identical protein binding
    		•  1.0030262164995 bayes_pls_golite062009
  • pattern binding
    		•  0.90497366619649 bayes_pls_golite062009
  • neurotrophin receptor binding
    		•  0.81172494974121 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.408562885230686 bayes_pls_golite062009
  • transcription activator activity
    		•  0.140318739604937 bayes_pls_golite062009
  • fibronectin binding
    		•  0.1110090445978 bayes_pls_golite062009
  • catalytic activity
    		•  0.105223830172599 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.0235054088545197 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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