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View Structure Prediction Details

Protein: dbl-1
Organism: Caenorhabditis elegans
Length: 365 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for dbl-1.

Description E-value Query
Range
Subject
Range
gi|3328182, gi|1... - gi|3328182|gb|AAC26791.1| CET-1 [Caenorhabditis elegans], pir||T43286 cet-1 protein - Caenorhabditis...
279.0 [0..1] [365..1]

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Predicted Domain #1
Region A:
Residues: [1-114]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNDSVRTTTT ISSTKSLVHS FQLSAILHLF LLISFTPMSA AADQHASHAT RRGLLRKLGL  60
   61 EHVPVQTGPS IDVPQHMWDI YDDDNDVDWV RHYYPKEIIE DNEGFLLSYN LSLA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [115-224]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ARNAHNEEVT KATLKLRLRR NNKARRSGNI SIYFFEDDIN NDRFQIESRS VDNLTEWIDF  60
   61 DVTAAFLRRT NRISFFIDLP EDVEIEETQS SSLSSLPYAR AQSAPLIVFS 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [225-365]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLSEPSSVRR KRSAQTGNSE RKNRKKGRKH HNTEAESNLC RRTDFYVDFD DLNWQDWIMA  60
   61 PKGYDAYQCQ GSCPNPMPAQ LNATNHAIIQ SLLHSLRPDE VPPPCCVPTE TSPLSILYMD 120
  121 VDKVIVIREY ADMRVESCGC R

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.0
Match: 1bmpA
Description: BONE MORPHOGENETIC PROTEIN-7
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor binding 4.70889547404918 bayes_pls_golite062009
cytokine activity 3.61376517935324 bayes_pls_golite062009
growth factor activity 3.55277889903829 bayes_pls_golite062009
platelet-derived growth factor binding 3.43601005070198 bayes_pls_golite062009
protein binding 3.16282476674164 bayes_pls_golite062009
cell surface binding 2.9725198156666 bayes_pls_golite062009
binding 2.37954321554411 bayes_pls_golite062009
receptor serine/threonine kinase binding 2.01478614969692 bayes_pls_golite062009
vascular endothelial growth factor receptor 1 binding 1.87722086999547 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding 1.87074199164241 bayes_pls_golite062009
transforming growth factor beta receptor binding 1.87074199164241 bayes_pls_golite062009
type II transforming growth factor beta receptor binding 1.74489645820593 bayes_pls_golite062009
glycosaminoglycan binding 1.67879530820663 bayes_pls_golite062009
collagen binding 1.64555624988816 bayes_pls_golite062009
protein dimerization activity 1.44846386076063 bayes_pls_golite062009
vascular endothelial growth factor receptor 2 binding 1.44790236067538 bayes_pls_golite062009
vascular endothelial growth factor receptor binding 1.43930353468665 bayes_pls_golite062009
hormone activity 1.39628583804208 bayes_pls_golite062009
heparin binding 1.30997160523692 bayes_pls_golite062009
growth factor binding 1.28535209856904 bayes_pls_golite062009
glial cell line-derived neurotrophic factor receptor binding 1.16821412683065 bayes_pls_golite062009
polysaccharide binding 1.16191864095271 bayes_pls_golite062009
protein homodimerization activity 1.13743310822539 bayes_pls_golite062009
platelet-derived growth factor receptor binding 1.12951786832285 bayes_pls_golite062009
identical protein binding 1.0030262164995 bayes_pls_golite062009
pattern binding 0.90497366619649 bayes_pls_golite062009
neurotrophin receptor binding 0.81172494974121 bayes_pls_golite062009
protein heterodimerization activity 0.408562885230686 bayes_pls_golite062009
transcription activator activity 0.140318739604937 bayes_pls_golite062009
fibronectin binding 0.1110090445978 bayes_pls_golite062009
catalytic activity 0.105223830172599 bayes_pls_golite062009
carbohydrate binding 0.0235054088545197 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle