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View Structure Prediction Details

Protein: dbl-1
Organism: Caenorhabditis elegans
Length: 365 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for dbl-1.

Description E-value Query
Range
Subject
Range
gi|3328182, gi|1... - gi|3328182|gb|AAC26791.1| CET-1 [Caenorhabditis elegans], pir||T43286 cet-1 protein - Caenorhabditis...
279.0 [0..1] [365..1]

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Predicted Domain #1
Region A:
Residues: [1-114]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNDSVRTTTT ISSTKSLVHS FQLSAILHLF LLISFTPMSA AADQHASHAT RRGLLRKLGL  60
   61 EHVPVQTGPS IDVPQHMWDI YDDDNDVDWV RHYYPKEIIE DNEGFLLSYN LSLA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [115-224]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ARNAHNEEVT KATLKLRLRR NNKARRSGNI SIYFFEDDIN NDRFQIESRS VDNLTEWIDF  60
   61 DVTAAFLRRT NRISFFIDLP EDVEIEETQS SSLSSLPYAR AQSAPLIVFS 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [225-365]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLSEPSSVRR KRSAQTGNSE RKNRKKGRKH HNTEAESNLC RRTDFYVDFD DLNWQDWIMA  60
   61 PKGYDAYQCQ GSCPNPMPAQ LNATNHAIIQ SLLHSLRPDE VPPPCCVPTE TSPLSILYMD 120
  121 VDKVIVIREY ADMRVESCGC R

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.0
Match: 1bmpA
Description: BONE MORPHOGENETIC PROTEIN-7
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor binding 4.70889547404918 bayes_pls_golite062009
cytokine activity 3.61376517935324 bayes_pls_golite062009
growth factor activity 3.55277889903829 bayes_pls_golite062009
platelet-derived growth factor binding 3.43601005070198 bayes_pls_golite062009
protein binding 3.16282476674164 bayes_pls_golite062009
cell surface binding 2.9725198156666 bayes_pls_golite062009
binding 2.37954321554411 bayes_pls_golite062009
receptor serine/threonine kinase binding 2.01478614969692 bayes_pls_golite062009
vascular endothelial growth factor receptor 1 binding 1.87722086999547 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding 1.87074199164241 bayes_pls_golite062009
transforming growth factor beta receptor binding 1.87074199164241 bayes_pls_golite062009
type II transforming growth factor beta receptor binding 1.74489645820593 bayes_pls_golite062009
glycosaminoglycan binding 1.67879530820663 bayes_pls_golite062009
collagen binding 1.64555624988816 bayes_pls_golite062009
protein dimerization activity 1.44846386076063 bayes_pls_golite062009
vascular endothelial growth factor receptor 2 binding 1.44790236067538 bayes_pls_golite062009
vascular endothelial growth factor receptor binding 1.43930353468665 bayes_pls_golite062009
hormone activity 1.39628583804208 bayes_pls_golite062009
heparin binding 1.30997160523692 bayes_pls_golite062009
growth factor binding 1.28535209856904 bayes_pls_golite062009
glial cell line-derived neurotrophic factor receptor binding 1.16821412683065 bayes_pls_golite062009
polysaccharide binding 1.16191864095271 bayes_pls_golite062009
protein homodimerization activity 1.13743310822539 bayes_pls_golite062009
platelet-derived growth factor receptor binding 1.12951786832285 bayes_pls_golite062009
identical protein binding 1.0030262164995 bayes_pls_golite062009
pattern binding 0.90497366619649 bayes_pls_golite062009
neurotrophin receptor binding 0.81172494974121 bayes_pls_golite062009
protein heterodimerization activity 0.408562885230686 bayes_pls_golite062009
transcription activator activity 0.140318739604937 bayes_pls_golite062009
fibronectin binding 0.1110090445978 bayes_pls_golite062009
catalytic activity 0.105223830172599 bayes_pls_golite062009
carbohydrate binding 0.0235054088545197 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle