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Protein Overview: lag-2

General Information:
Name(s) found: lag-2 / CE22970 [WormBase]
Description(s) found:
Found 24 descriptions.
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  • WBGene00002246 locus:lag-2 Protein lag-2 status:Partially_confirmed UniProt:P45442 protein_id:CCD66873.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 402 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEALink to PubMed article]
    Biological Process: gonad development [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    cell communication [IEALink to PubMed article]
    germ-line stem cell division [IMPLink to PubMed article]
    cell fate specification [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    regulation of vulval development [IMPLink to PubMed article]
    Molecular Function: calcium ion binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIAYFLLLLT CLPVLQARVE VHQEFISSKR VSVRFEIVTE SHSPNRPVTF DLFPRGPKTN  60
   61 IILLDTFNPV FNFSIQLVQP FTGQPLGDRI YRKVQFSGTN QPWINDTFTT TSGISLSVAT 120
  121 EVTCARNYFG NRCENFCDAH LAKAARKRCD AMGRLRCDIG WMGPHCGQAV DPRKCSCEND 180
  181 GICVSSMIHP SQPNQTSSNE QLICECTNGF TGTRCEIFGF NQFQLTAPRP DACSVKDACL 240
  241 NGAKCFPNGP KVFCSCAVGF IGEFCEISLT TTTPTTVEIT VSTSGYSSAV YITVALFVIF 300
  301 SIIIGCFKYK FKPMRQQALA RGQVPEPYKM PETKSMLIDP EASEAQKKVF TIEGSVQKID 360
  361 EEVRYTSAPR KYESNNEYAV IQKSTPPPPS LSPPSIPACH YV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..402] PSI-BLAST 12.30103 Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.44119144078508 bayes_pls_golite062009
  • receptor binding
    		•  1.40618339011373 bayes_pls_golite062009
  • protein binding
    		•  1.15716342217655 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  1.04038130958316 bayes_pls_golite062009
  • growth factor activity
    		•  0.25853515067422 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle