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View Structure Prediction Details

Protein: lag-2
Organism: Caenorhabditis elegans
Length: 402 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for lag-2.

Description E-value Query
Range
Subject
Range
gi|115893463, gi... - gi|115930648|ref|XP_001178590.1| PREDICTED: similar to fibropellin Ib [Strongylocentrotus purpuratus...
276.0 [0..3] [353..1521]

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Predicted Domain #1
Region A:
Residues: [1-402]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIAYFLLLLT CLPVLQARVE VHQEFISSKR VSVRFEIVTE SHSPNRPVTF DLFPRGPKTN  60
   61 IILLDTFNPV FNFSIQLVQP FTGQPLGDRI YRKVQFSGTN QPWINDTFTT TSGISLSVAT 120
  121 EVTCARNYFG NRCENFCDAH LAKAARKRCD AMGRLRCDIG WMGPHCGQAV DPRKCSCEND 180
  181 GICVSSMIHP SQPNQTSSNE QLICECTNGF TGTRCEIFGF NQFQLTAPRP DACSVKDACL 240
  241 NGAKCFPNGP KVFCSCAVGF IGEFCEISLT TTTPTTVEIT VSTSGYSSAV YITVALFVIF 300
  301 SIIIGCFKYK FKPMRQQALA RGQVPEPYKM PETKSMLIDP EASEAQKKVF TIEGSVQKID 360
  361 EEVRYTSAPR KYESNNEYAV IQKSTPPPPS LSPPSIPACH YV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.30103
Match: 1n7dA
Description: Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.44119144078508 bayes_pls_golite062009
receptor binding 1.40618339011373 bayes_pls_golite062009
protein binding 1.15716342217655 bayes_pls_golite062009
ErbB-2 class receptor binding 1.04038130958316 bayes_pls_golite062009
growth factor activity 0.25853515067422 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle