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Protein Overview: pah-1

General Information:
Name(s) found: pah-1 / CE21050 [WormBase]
Description(s) found:
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  • WBGene00000240 locus:pah-1 Probable phenylalanine-4-hydroxylase 1 status:Confirmed UniProt:P90925 protein_id:CAA91286.1 [WormBase]
  • pir||T23494 phenylalanine 4-monooxygenase (EC 1.14.16.1) K08F8.4 [similarity] - Caenorhabditis elegans [NCBI NR]
  • gi|6226669|sp|P90925.2|PH4H_CAEEL RecName: Full=Probable phenylalanine-4-hydroxylase 1; Short=PAH; AltName: Full=Phe-4-monooxygenase; AltName: Full=Biogenic amine synthesis protein 2 [NCBI NR]
  • gi|3979833|emb|CAA91286.1| C. elegans protein K08F8.4, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|17531391|ref|NP_495863.1| PhenylAlanine Hydroxylase family member (pah-1) [Caenorhabditis elegans] [NCBI NR]
  • Probable phenylalanine-4-hydroxylase 1 OS=Caenorhabditis elegans GN=pah-1 PE=1 SV=2 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE21050 WBGene00000240 locus:pah-1 phenylalanine-4-hydroxylase (PH4H) status:Confirmed SW:P90925 protein_id:CAA91286.1 [wormpep150.fasta]
  • 21050 WBGene00000240 locus:bas-2 phenylalanine-4-hydroxylase (PH4H) status:Confirmed SW:P90925 protein_id:CAA91286.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • phenylalanine hydroxylase, Biogenic Amine Synthesis related (52.1 kD) (bas-2) [Caenorhabditis elegans]gi|3979833|emb|CAA91286.1| Hypothetical protein K08F8.4 [Caenorhabditis elegans]gi|7505579|pir||T23494 phenylalanine 4-monooxygenase (EC 1.14.16.1) K08 [nrdb_11152004_Chlamydomonas]
  • CE21050 WBGene00000240 locus:bas-2 phenylalanine-4-hydroxylase (PH4H) status:Confirmed SW:P90925 protein_id:CAA91286.1 [wormpep132.fasta]
  • 21050 WBGene00000240 locus:pah-1 phenylalanine-4-hydroxylase (PH4H) status:Confirmed SW:P90925 protein_id:CAA91286.1 [wormpep150-phg-orf-ecoli-rand.fasta]
  • locus:bas-2 phenylalanine-4-hydroxylase (PH4H) status:Confirmed SW:P90925 protein_id:CAA91286.1 [wormpep115.fasta.reversed]
  • CE21050 locus:bas-2 phenylalanine-4-hydroxylase (PH4H) status:Confirmed SW:P90925 protein_id:CAA91286.1 [wormpep80.hongbin]
  • CE21050 WBGene00000240 locus:pah-1 phenylalanine-4-hydroxylase (PH4H) status:Confirmed UniProt:PH4H_CAEEL protein_id:CAA91286.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE21050 WBGene00000240 locus:pah-1 phenylalanine-4-hydroxylase (PH4H) status:Confirmed UniProt:PH4H_CAEEL protein_id:CAA91286.1| [wormORF-contam.fasta]
  • Probable phenylalanine-4-hydroxylase 1 (PAH) (Phe-4-monooxygenase) (Biogenic amine synthesis protein 2) [nr-271106-contam.fasta]
  • Hypothetical protein K08F8.4 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • PhenylAlanine Hydroxylase family member (pah-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE21050 WBGene00000240 locus:pah-1 phenylalanine-4-hydroxylase (PH4H) status:Confirmed UniProt:P90925 protein_id:CAA91286.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE21050 WBGene00000240 locus:pah-1 status:Confirmed UniProt:P90925 protein_id:CAA91286.1 Probable phenylalanine-4-hydroxylase 1 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 457 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: serotonin biosynthetic process [IEALink to PubMed article]
    aromatic amino acid family metabolic process [IEALink to PubMed article]
    L-phenylalanine catabolic process [IEALink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    metabolic process [IEALink to PubMed article]
    catecholamine biosynthetic process [IEALink to PubMed article]
    Molecular Function: iron ion binding [IEALink to PubMed article]
    phenylalanine 4-monooxygenase activity [IEALink to PubMed article]
    amino acid binding [IEALink to PubMed article]
    monooxygenase activity [IEALink to PubMed article]
    tyrosine 3-monooxygenase activity [IEALink to PubMed article]
    tryptophan 5-monooxygenase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPAGQDDLD FLKYAMESYV ADVNADIGKT TIVFTLREKA GALAETLKLF QAHDVNLSHI  60
   61 ESRPSKTHEG CYEVLVEFAE AEDHRKIEGV IEHFQQKAEK KVLVQDWNTK NKQNKDSVPW 120
  121 FPQKINDIDQ FANRILSYGA ELDADHPGFK DMTYRERRKF FADIAFNFKH GDKIPTITYT 180
  181 DEEIATWRTV YNELTVMYPK NACQEFNYIF PLLQQNCGFG PDRIPQLQDV SDFLKDCTGY 240
  241 TIRPVAGLLS SRDFLAGLAF RVFHSTQYIR HHSAPKYTPE PDICHELLGH VPLFADVEFA 300
  301 QFSQEIGLAS LGAPDDVIEK LATLYWFTIE FGICQQDGEK KAYGAGLLSS FGELQYALSD 360
  361 KPEVVDFDPA VCCVTKYPIT EYQPKYFLAE SFASAKNKLK SWAATINRPF QIRYNAYTQR 420
  421 VEILDKVAAL QRLARDIRSD ISTLEEALGK VNNLKMK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..457] PSI-BLAST 158.0 Phenylalanine hydroxylase N-terminal domain; Phenylalanine hydroxylase, PAH

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
    		•  5.95179224585512 bayes_pls_golite062009
  • tyrosine 3-monooxygenase activity
    		•  5.29200621320545 bayes_pls_golite062009
  • phenylalanine 4-monooxygenase activity
    		•  5.13697132751033 bayes_pls_golite062009
  • acetolactate synthase activity
    		•  3.48670706716817 bayes_pls_golite062009
  • tryptophan 5-monooxygenase activity
    		•  3.21197226254744 bayes_pls_golite062009
  • transferase activity, transferring aldehyde or ketonic groups
    		•  2.5269324625528 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
    		•  2.3423688142986 bayes_pls_golite062009
  • monooxygenase activity
    		•  1.6613930139243 bayes_pls_golite062009
  • binding
    		•  1.10693426788511 bayes_pls_golite062009
  • transferase activity
    		•  1.02290254973777 bayes_pls_golite062009
  • catalytic activity
    		•  0.932947046865376 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.699576439508937 bayes_pls_golite062009
  • protein binding
    		•  0.431526081681418 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle