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Protein Overview: spk-1

General Information:
Name(s) found: spk-1 / CE20457 [WormBase]
Description(s) found:
Found 22 descriptions.
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  • WBGene00004980 locus:spk-1 Serine\/threonine-protein kinase spk-1 status:Confirmed UniProt:Q03563 protein_id:CAA79541.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 698 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: embryonic cleavage [IMPLink to PubMed article]
    hermaphrodite genitalia development [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed article]
    cytokinesis [IMPLink to PubMed article]
    protein amino acid phosphorylation [IEALink to PubMed article]
    reproduction [IMPLink to PubMed article]
    Molecular Function: magnesium ion binding [IEALink to PubMed article]
    ATP binding [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGGPEKNSTV PLPNKKRKKK TNKKKPTAPN TPTSPQAGEK NANLKNGTVT TNGSNHVERT  60
   61 EVNANEERLD DLSVSPGRSD SPGGGGGGHS DSFQDPMDPG EQLGSDDEEQ EDPRDYKRGG 120
  121 YHPVNIGDVF NARYHVIRKL GWGHFSTVWL AWDTQDKRFV AMKIVKSAEH YTEAALDEIK 180
  181 LLLSVRSADP NDIGCHKVVQ LLDEFTVTGI NGQHVAMVFE VLGCNLLKLI IRSNYRGLHL 240
  241 EQVRKICRQV LEALGYMHEK CGIIHTDIKP ENVLITMSRE EIKIMAQHAV VARKMNMKMS 300
  301 GSAVSTAPDH LVKMAQENMT KNKKKKMKKK AKKQREKLEA ELAGLEGLKM DANGLQEAYN 360
  361 NAPELENFNA SQVEDVTMED TVNENGNRNK VEIRSPDRFD RTTLTPFSDP ESKFGDLASP 420
  421 SAEYLSSPMS QLPPGGILPA PPVGPNIGDP YCDIDVKIAD LGNACWVNHH YTDDIQTRQY 480
  481 RALEVLIGSG YGPPADIWST ACMAFELATG DYLFEPHQGD NYSRDEDHLA HISELLGAIP 540
  541 PSIYKKGKHW REFFHKNGHL LHIHQLKPWS LYEVLRQKYE WSHEDAQQFE SFLRPMLDFD 600
  601 QEKRSTAKIA LKHPFLLPFG GRAPKSDCPP ELLSKMFPDG LIPEPFDGNE HQEVYRDEND 660
  661 SRSASERSAN SRSAGGSDDD DEEEFNMNRP GPSGLDLQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-2 hcp2 ip from december Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..104] deduced N/A No confident structure predictions are available.
    2 View Details [105..355] PSI-BLAST 54.045757 No description for 1wakA was found.
    3 View Details [356..414] deduced N/A No confident structure predictions are available.
    4 View Details [415..698] PSI-BLAST 54.154902 THE C-JUN N-TERMINAL KINASE (JNK3S) COMPLEXED WITH MGAMP-PNP

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • protein kinase activity
    		•  5.08693983533348 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  4.80278598786839 bayes_pls_golite062009
  • kinase activity
    		•  4.59756610116144 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.25355168820731 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.23864440079487 bayes_pls_golite062009
  • transferase activity
    		•  3.26787750561728 bayes_pls_golite062009
  • ATP binding
    		•  1.87003701072722 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.82650528610717 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.79644024762454 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.56978145564551 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.56956819263374 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.54471996792105 bayes_pls_golite062009
  • nucleotide binding
    		•  1.53595022832543 bayes_pls_golite062009
  • binding
    		•  1.2544309640633 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.17063753242103 bayes_pls_golite062009
  • protein binding
    		•  1.1071219729093 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.05410128646972 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.98751004123886 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.439470338563384 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.0936583701619971 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle