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Protein Overview: efl-1

General Information:
Name(s) found: efl-1 / CE20390 [WormBase]
Description(s) found:
Found 20 descriptions.
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  • WBGene00001161 locus:efl-1 status:Confirmed UniProt:G5EF11 protein_id:CAA20948.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 342 amino acids

    Gene Ontology:
    Cellular Component: nucleus [TASLink to PubMed article]
    transcription factor complex [IEALink to PubMed article]
    Biological Process: negative regulation of vulval development [IMPLink to PubMed article]
    negative regulation of Ras protein signal transduction [IMPLink to PubMed article]
    negative regulation of S phase of mitotic cell cycle [IMPLink to PubMed article]
    negative regulation of transcription [TASLink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    embryonic digestive tract morphogenesis [IGILink to PubMed article]
    Molecular Function: transcription factor activity [IEALink to PubMed article]
    transcription repressor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDSYNDMED PGFRQLSDME LQKALEMTKQ SSIKNNLMLG LDNELDFDFD FDEDEDLDQP  60
   61 QMGTRADKSL GLLAKRFIRM IQYSPYGRCD LNTAAEALNV RQKRRIYDIT NVLEGIGLIE 120
  121 KRSKNMIQWK GGDFMLNVKE GKRQSATTEE EDRMEQLKAE IEQLNKEEEL IEQRQRWLQQ 180
  181 SLRNMTESVE NNKLSYVLRS QLAEIQGSDL TIGIQTRVGT QVRLSDPEQV EIHGGPSWCY 240
  241 LKDPSGPLRA AIVSNHELHD FVQRERAKRP GEEHVDADAP DEMMDDSRYR NRRTINDDEM 300
  301 FGFEQKVPAM KHLEPPPASD DYVYSSTGDE YRGDSIVDLY GD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..136] PSI-BLAST 26.69897 Cell cycle transcription factor E2F-4
    2 View Details [137..264] PSI-BLAST 18.154902 Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer
    3 View Details [265..342] MSA 1.093994 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle