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Protein Overview: let-49

General Information:
Name(s) found: let-49 / CE19227 [WormBase]
Description(s) found:
Found 17 descriptions.
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  • WBGene00002324 locus:let-49 Mediator of RNA polymerase II transcription subunit 7 status:Confirmed UniProt:Q95Q17 protein_id:CAA21715.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 253 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    Biological Process: hermaphrodite genitalia development [IMPLink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    gonad development [IMPLink to PubMed article]
    morphogenesis of an epithelium [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    gastrulation with mouth forming first [IMPLink to PubMed article]
    positive regulation of transcription [IEALink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    positive regulation of multicellular organism growth [IMPLink to PubMed article]
    Molecular Function: transcription coactivator activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLPGFGAQTV SPFPNPPEYA SAYTSDRINN DSGSAPPPPH PLTEFKVYGE EYRLEDDVIA  60
   61 PLKNAGVAEL YKNKNNWKTE MKKLNRSAIV AFFDLVEILI RAPDHPMREE KMVDLHTIFI 120
  121 NMHHLINEFR PVQARDSVRI LQERQIEELS DICKDFKKYL RDGREVVDDQ FQMIRGKLPA 180
  181 PPQPSELTRV KLQDGVLHML QETEASDDVE MKEEEGSEYS KKKARLELLS REDGPPSVVH 240
  241 LLARQFHDIS LKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..92] Pfam 15.0 No description for PF05983.2 was found. No confident structure predictions are available.
    2 View Details [93..179] PSI-BLAST 20.154902 Structure of the mediator MED7/MED21 subcomplex
    3 View Details [180..253] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle