YRC Public Data Repository - Protein Structure Prediction

Protein:	let-49
Organism:	Caenorhabditis elegans
Length:	253 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for let-49.

Description	E-value	Query Range	Subject Range
let-49 - status:Confirmed UniProt:Q95Q17 protein_id:CAC42382.1	378.0	[0..1]	[253..1]
gi\|157748745 - gi\|157748745\|ref\|XP_001669467.1\| Hypothetical protein CBG19704 [Caenorhabditis briggsae AF16] MED7_CAEBR - Mediator of RNA polymerase II transcription subunit 7 OS=Caenorhabditis briggsae GN=let-49 PE=3 SV=1	318.0	[0..1]	[253..1]
gi\|55730559 - gi\|55730559\|emb\|CAH92001.1\| hypothetical protein [Pongo abelii] gi\|55730559\|emb\|... - hypothetical protein [Pongo pygmaeus]	260.0	[0..8]	[223..5]
gi\|109487990, gi... - gi\|109490586\|ref\|XP_001069084.1\| PREDICTED: similar to Cofactor required for Sp1 transcriptional act...	255.0	[0..8]	[225..5]
gi\|73954132 - gi\|73954132\|ref\|XP_536456.2\| PREDICTED: similar to Cofactor required for Sp1 transcriptional activat...	255.0	[0..8]	[223..5]
MED7_DANRE - Mediator of RNA polymerase II transcription subunit 7 OS=Danio rerio GN=med7 PE=2 SV=1	246.0	[0..8]	[185..5]
gi\|50754981 - gi\|50754981\|ref\|XP_414569.1\| PREDICTED: similar to Cofactor required for Sp1 transcriptional activat...	235.0	[0..8]	[179..5]
MED7A_XENLA - Mediator of RNA polymerase II transcription subunit 7-A OS=Xenopus laevis GN=med7-a PE=2 SV=1	230.0	[0..8]	[227..5]
gi\|113205910, gi... - gi\|77745597\|gb\|ABB02676.1\| cofactor required for Sp1 transcriptional activation subunit 9 [Sus scrof...	230.0	[0..8]	[179..5]

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Predicted Domain #1

Region A:
Residues: [1-92]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLPGFGAQTV SPFPNPPEYA SAYTSDRINN DSGSAPPPPH PLTEFKVYGE EYRLEDDVIA  60
   61 PLKNAGVAEL YKNKNNWKTE MKKLNRSAIV AF

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	15.0
Match:	PF05983.2
Description:	No description for PF05983.2 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [93-179]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FDLVEILIRA PDHPMREEKM VDLHTIFINM HHLINEFRPV QARDSVRILQ ERQIEELSDI  60
   61 CKDFKKYLRD GREVVDDQFQ MIRGKLP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	20.154902
Match:	1ykeA
Description:	Structure of the mediator MED7/MED21 subcomplex
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [180-253]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APPQPSELTR VKLQDGVLHM LQETEASDDV EMKEEEGSEY SKKKARLELL SREDGPPSVV  60
   61 HLLARQFHDI SLKK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits