Protein Overview: sdc-2

General Information:
Name(s) found:	sdc-2 / CE18542 [WormBase]
Description(s) found: SHOW ONLY BEST	WBGene00004746 locus:sdc-2 status:Confirmed UniProt:G5EBL3 protein_id:CAB01693.1 [WormBase] pir\|\|T19756 hypothetical protein C35C5.1 - Caenorhabditis elegans [NCBI NR] gi\|4336899\|gb\|AAD18003.1\| SDC-2 [Caenorhabditis elegans] [NCBI NR] gi\|3876485\|emb\|CAB01756.1\| C. elegans protein C35C5.1, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR] gi\|3874773\|emb\|CAB01693.1\| C. elegans protein C35C5.1, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR] gi\|17569439\|ref\|NP_509924.1\| Sex determination and Dosage Compensation defect family member (sdc-2) [Caenorhabditis elegans] [NCBI NR] [wormpep67.fasta] CE18542 WBGene00004746 locus:sdc-2 status:Confirmed TR:Q93326 protein_id:CAB01756.1 [wormpep150.fasta] 18542 WBGene00004746 locus:sdc-2 status:Confirmed TR:Q93326 protein_id:CAB01756.1 [wormpep130-phg-ecoli-orf-rand.fasta] nematode specific protein required for X chromosome dosage compensation and hermaphrodite sex determination., Sex determination and Dosage Compensation defect SDC-2 (344.4 kD) (sdc-2) [Caenorhabditis elegans]gi\|3876485\|emb\|CAB01756.1\| Hypothetical protei [nrdb_11152004_Chlamydomonas] locus:sdc-2 status:Confirmed TR:Q93326 protein_id:CAB01756.1 [wormpep115.fasta.reversed] CE18542 locus:sdc-2 status:Confirmed TR:Q93326 protein_id:CAB01756.1 [wormpep80.hongbin] CE18542 WBGene00004746 locus:sdc-2 status:Confirmed UniProt:Q93326_CAEEL protein_id:CAB01756.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta] CE18542 WBGene00004746 locus:sdc-2 status:Confirmed UniProt:Q93326_CAEEL protein_id:CAB01756.1\| [wormORF-contam.fasta] SDC-2 [Caenorhabditis elegans] [nr-271106-contam.fasta] Hypothetical protein C35C5.1 [Caenorhabditis elegans] [nr-271106-contam.fasta] Sex determination and Dosage Compensation defect family member (sdc-2) [Caenorhabditis elegans] [nr-271106-contam.fasta] CE18542 WBGene00004746 locus:sdc-2 status:Confirmed UniProt:Q93326 protein_id:CAB01756.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta] [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr] CE18542 WBGene00004746 locus:sdc-2 status:Confirmed UniProt:G5EBL3 protein_id:CAB01693.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta] SDC-2 OS=Caenorhabditis elegans GN=sdc-2 PE=1 SV=1 [CAEEL.fasta.20160308]
Organism:	Caenorhabditis elegans
Length:	2962 amino acids
Gene Ontology:
Cellular Component:	nuclear chromosome [IDA] proteinaceous extracellular matrix [IEA]
Biological Process:	hermaphrodite genitalia development [IMP] embryonic development ending in birth or egg hatching [IMP ] positive regulation of growth rate [IMP ] determination of adult lifespan [IMP] post-embryonic body morphogenesis [IMP] dosage compensation, by hypoactivation of X chromosome [IMP] cell adhesion [IEA] blood coagulation [IEA] growth [IMP] positive regulation of multicellular organism growth [IMP ] negative regulation of transcription from RNA polymerase II promoter [IMP] locomotory behavior [IMP ] nematode larval development [IMP ] negative regulation of transcription [IMP]
Molecular Function:	transcription repressor activity [IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDESELGNQ SEMESFNESD SPDEADPDVV IIHDIVHLRA STTGDYSQSE IGKLPEQNTF  60
   61 FLPGRVKRNI SSNDSDVIID EDEIPDGAIR ITSDTHFIGS SRGTSELGDF EMDEQEFLNI 120
  121 TIEENGNEQE LEEHLRNAYR HEEEECFEEE DDIIELPPLP VKPAVKKPRR KLPKHLSIES 180
  181 GSTAKTSKLV AEVVHDHPRP VNYRMKPAVT DDGKVVEQKR TRVTRNIMSH TIPQYHLEGE 240
  241 ETEFGRVKES TLSKTIEQYL QAGKLVSPKC DQFREQIVAT AVEYDGSVKM LQFENALKKH 300
  301 SGKQKRLKYQ TGWWKASKSH YERAVNGYVA MPKTPVLSIS DDPVLYKHHS LFPKNQSSEL 360
  361 EKINVQLRIR LNSKRQNNDV IPDSSYFVRE FLMQKHSISL RMNRSSDLPE LFVPPTLECG 420
  421 YFPQDAVTVQ QQEHYLMMRF EEAQDEYHNI TYRSIAPPVE FQVGTISAKE LHKFHRIGRH 480
  481 IHGFFVVWEN KFPEYDESGI CCPRKRYLVD MFNLICFPLY TEYEQWESRL RVAFDKTIVY 540
  541 NLHLSEILRC NRPVFDFLSK NKSMLQPITL KEIVYLIEQS NMDAKSFAVK FGLRTFYDHG 600
  601 RATSNKDYLS AFLIITGGAK VVTEEIDSER LRVFNSDYME SGVLTSSGDV YTFEFDKIPN 660
  661 NYQISIGCNA DGVAEMEQED VRHELSECSS RITRIIGDSK KPEKIIARPL VKTNQNDGMK 720
  721 FFTRKDLLNY RIKLYDPSYV VPRAKKQIVN EPAKKKPGRK SKTRYDAAMQ QNNFEIEGVP 780
  781 SDVDSEFEGY LSDSENVFQK PSKLMRSTSS DSVFIDYQYR EKMFLDVSWF HQQKMIDRSL 840
  841 PPLKKRKRKM NRIYHKHSVR YTMLQANGCA FTEMYRCYDK ILPCGTKEIA RTKNAIRFPH 900
  901 RFRTYNIPQV YGPGDKQLIT EVFGVVKDVI TRATGFESAS IRTANDIAQA VYDANIARRE 960
  961 LLENLEPSDN GILPSPAYLA IEMLSHQKMS GRLCLESARK DVQNNVDKMY NDYMDLDPLD1020
 1021 KELHFEISQS IRQSKLNESL EEYERNRERQ LAKTLKTVPM DKRSQAALAR REEKRRESRR1080
 1081 KLADKYAEQR RMMASTRRLE KRTTQKQVDP ETIQRLRRED EVRKRKRFEE EDRRGMIRRR1140
 1141 EERVALQEKV DRMLEEGLRL EKVREAERIR QQQEEERIEM ETILISRRVR EEEEEKMRLE1200
 1201 RLRKAERERE QERLKREEEE ERKRLEQLRE AEKLKAEIEK ENERKLQEER TRKALELERK1260
 1261 IEEIKRVSTL KDMFGPLPIA KENEQTEKDF QILLDDHELT LLTISRDPLN EKYQEARTEF1320
 1321 ERLDIKSMLL RKAEKLIDVL TIHYDVPIEQ TCRYFTSSIE SNENRMAVNE QLNKLFENMA1380
 1381 NCFTFNIQDG ENGLQSKRKW DFQFKKCAVF DGVSQSTVNF IEEKMRENTK KKHLATPKTV1440
 1441 ISIDTSLLKQ SLLRSHARFD PDISLYAQNH TANSIGDVTL KMSNYSLDFA TQSIHDKELA1500
 1501 EKATPKKGPT VRRHIKNLFG SEKVIVRRSL AAGKPASLNS EDSDSEDSRE GSPVAEFLPT1560
 1561 NPVCSFWKLV VKIENSTTDK EKTELCEDLD KLILRKDDLF SKSLKWMFPL LATFYVLLSN1620
 1621 AVLNENEEII SDKNQTGVTK DEILKSTIND LMIIAAYFEE GSRERSNLRK MISMNGFSVV1680
 1681 FNRVILFAKK TCTLAKELES NSRSLSGYVI EDLFESLLAE IERTMRQELG SSVRKTGKLE1740
 1741 RDFEEIVKLI QNEKKLALSH KSHKNDENRR FRLNTVVKWY DAIICHCKEE LTQAIVDAFP1800
 1801 LNAITKNKET SHVAMENGDD EAMLSDTSDN QMSTTDYQMP KNICRNSEIF PEDAFAKAYA1860
 1861 VVRIPSKKER AQMLSVYRKK NAQSGCVENK GLSRMPKFEE PFVDSVWRTI EKRINNMTHS1920
 1921 EEKQIKRFIP VSRSHKLNEK VKFYAMVMIQ ERDSRDTRLF NSKFQDDNLW HCYSKSSLNH1980
 1981 EKMESRILQH IEHTVLSKSN FNQMKWSVQC VNGNKKDAIH YFTDLYKYRS ESEFRSALSC2040
 2041 GKLKFNFKVY THLWFMGNLL PTSYNPDSHD DKLFVPCSGC TSGDVIIIHK CTCAYHNDTF2100
 2101 SDKFIYANTS LPVGIDKVTR LVGRFVCEHG PSSFLILEHC SANVDANIPF ESENVEFSAE2160
 2161 LRIVKRKTMH SQLVKTFAEE HTHLRDASRH RAISTVTLDS SGSGRSTRCE IFEDSPSEDE2220
 2221 NDENQLDTTR IGRKIDPIIV DSDKAYLIAE GERMALRIKR LLDPELQKFR SKNFVSRSKS2280
 2281 VDAPKTSKQK TVIRRSQSVC DLNDVNEYAQ KKVRNTKDSF ATLFRDHEYS TRRTYEEQLN2340
 2341 NELLDVVTTF GGASNVSADK KYNILASILA FEKEVQLVND KNGELFKTVS NLVQRNSLQH2400
 2401 VKGVILAEDN QTLRSTDNTS EVFPESKAVN EYLKFEIYKR KMMVNAKLMA DTVKDLKLKH2460
 2461 AEYRPFAKLI ATYDSIFKFN VYLFEHFLNC ISKHVFNPYA IYCEETRPTG TELSKFQLTL2520
 2521 KLIETSMPTV LSMLFNTEPL RRQLSELSEI HKKVRSEDLA CTIASLCRYA IERIRIPQTA2580
 2581 DKRLCDFSWL NSAEDHRETV SFIRLTLEHT LPDMKTENEQ TRFVEFLKEA EGFHFSYKFV2640
 2641 EAQCKTFVRN HGDSKQAFFT AFYNQNEAFY GSLQKFMSNG TIDPKMKLYY QHQAFLRLHN2700
 2701 IVKKRSHIIT SDDYHRSSDV CKAMLLSEIV SNPKIAQEAY ISGSVLDRMY TSLCKIKAKM2760
 2761 PLISPSYIGT SLTCFEDELL FSAVREAKVH TDTRVVFRSK SCMRPNEKAG DANFKTCKVT2820
 2821 LLVNLETALL SMVFKSRDQS EIDKDDRLDI DILDEEVIKP IIDWNRIFET FIQPTYNTLF2880
 2881 SRMEKRERVS ILPENPLGRL ENYAFTNPNQ DKDCQAVLEY IDVASDTDAE ESIEDPLDIV2940
 2941 EMTLKRALPR SMSPSSKRRR MR

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	hcp-2	hcp2 ip from december	Cheeseman, I.M., et al. (2005)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: sdc-2

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: