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Protein Overview: aph-1

General Information:
Name(s) found: aph-1 / CE16526 [WormBase]
Description(s) found:
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  • WBGene00000147 locus:aph-1 Gamma-secretase subunit aph-1 status:Confirmed UniProt:O45876 protein_id:CAA16282.1 [WormBase]
  • pir||T26007 hypothetical protein VF36H2L.1 - Caenorhabditis elegans [NCBI NR]
  • gi|3880371|emb|CAA16282.1| C. elegans protein VF36H2L.1, partially confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|37076812|sp|O45876.1|APH1_CAEEL RecName: Full=Gamma-secretase subunit aph-1; AltName: Full=Anterior-pharynx-defective protein 1; AltName: Full=Presenilin enhancer protein 1 [NCBI NR]
  • gi|17509423|ref|NP_492469.1| Anterior PHarynx defective family member (aph-1) [Caenorhabditis elegans] [NCBI NR]
  • Gamma-secretase subunit aph-1 OS=Caenorhabditis elegans GN=aph-1 PE=1 SV=1 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE16526 WBGene00000147 locus:aph-1 status:Partially_confirmed SW:O45876 protein_id:CAA16282.1 [wormpep150.fasta]
  • 16526 WBGene00000147 locus:aph-1 status:Partially_confirmed SW:O45876 protein_id:CAA16282.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • i-78 protein like, Anterior PHarynx defective APH-1, Presenilin ENhancer (enhancer of sel-12 null) PEN-1 (aph-1) [Caenorhabditis elegans]gi|3880371|emb|CAA16282.1| Hypothetical protein VF36H2L.1 [Caenorhabditis elegans]gi|7508722|pir||T26007 hypothetica [nrdb_11152004_Chlamydomonas]
  • locus:aph-1 status:Partially_confirmed SW:O45876 protein_id:CAA16282.1 [wormpep115.fasta.reversed]
  • CE16526 locus:aph-1 status:Partially_confirmed TR:O45876 protein_id:CAA16282.1 [wormpep80.hongbin]
  • CE16526 WBGene00000147 locus:aph-1 status:Partially_confirmed UniProt:O45876 protein_id:CAA16282.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE16526 WBGene00000147 locus:aph-1 status:Partially_confirmed UniProt:O45876 protein_id:CAA16282.1| [wormORF-contam.fasta]
  • Gamma-secretase subunit aph-1 (Anterior-pharynx-defective protein 1) (Presenilin enhancer protein 1) [nr-271106-contam.fasta]
  • Hypothetical protein VF36H2L.1 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Anterior PHarynx defective family member (aph-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE16526 WBGene00000147 locus:aph-1 status:Confirmed UniProt:O45876 protein_id:CAA16282.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE16526 WBGene00000147 locus:aph-1 status:Confirmed UniProt:O45876 protein_id:CAA16282.1 Gamma-secretase subunit aph-1 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 308 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [IEALink to PubMed article]
    Biological Process: locomotory behavior [IMPLink to PubMed article]
    positive regulation of catalytic activity [IEALink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    protein processing [IEALink to PubMed article]
    Molecular Function: protein binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGYLLTIACY IASFSPSIAL FCSFIAHDPV RIILFFLGSF FWLVSLLFSS LAWLGLSTVL  60
   61 PDTFLLSLTV CIIAQELSRV AYFMLLKKAQ RGLNKITRQG QISVAPGVSD LHNARHMLAL 120
  121 VCGLGMGVIS ALFYTMNAFA IFSGPGTIGL PNALKTGEID TNRAGKYLPL CYTLSAILLT 180
  181 LFHVTWTIMV WDSCHKIGRI PSAFVPGAAA VVSHLLVTFL SSLNSRGFHV LVFAVQFLIL 240
  241 LICIAYCNVI MGGTISSFVN GIGQSITDAV TLKQVRTLIE ERKLRTQRQS VPDEPMTERA 300
  301 GTSNTVNA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..87] MSA 2.01998 View MSA. No confident structure predictions are available.
    2 View Details [88..308] MSA 1.018955 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle