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Protein Overview: lmn-1

General Information:
Name(s) found: lmn-1 / CE15746 [WormBase]
Description(s) found:
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  • WBGene00003052 locus:lmn-1 Lamin-1 status:Confirmed UniProt:Q21443 protein_id:CAB09411.1 [WormBase]
  • pir||T20390 hypothetical protein DY3.2 - Caenorhabditis elegans [NCBI NR]
  • gi|46576888|sp|Q21443.2|LMN1_CAEEL RecName: Full=Lamin-1; AltName: Full=CeLam-1; AltName: Full=Ce-lamin [NCBI NR]
  • gi|3875347|emb|CAB09411.1| C. elegans protein DY3.2, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|17506429|ref|NP_492371.1| nuclear LaMiN family member (lmn-1) [Caenorhabditis elegans] [NCBI NR]
  • Lamin-1 OS=Caenorhabditis elegans GN=lmn-1 PE=1 SV=2 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE15746 WBGene00003052 locus:lmn-1 Intermediate filament proteins (2 domains) status:Confirmed SW:Q21443 protein_id:CAB09411.1 [wormpep150.fasta]
  • 15746 WBGene00003052 locus:lmn-1 Intermediate filament proteins (2 domains) status:Confirmed SW:Q21443 protein_id:CAB09411.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • nuclear LaMiN (64.1 kD) (lmn-1) [Caenorhabditis elegans]gi|3875347|emb|CAB09411.1| Hypothetical protein DY3.2 [Caenorhabditis elegans]gi|7498272|pir||T20390 hypothetical protein DY3.2 - Caenorhabditis elegansgi|46576888|sp|Q21443|LMN1_CAEEL Lamin 1 (Ce [nrdb_11152004_Chlamydomonas]
  • locus:lmn-1 Intermediate filament proteins (2 domains) status:Confirmed TR:O62127 protein_id:CAB09411.1 [wormpep115.fasta.reversed]
  • CE15746 locus:lmn-1 Intermediate filament proteins (2 domains) status:Partially_confirmed TR:O62127 protein_id:CAB09411.1 [wormpep80.hongbin]
  • CE15746 WBGene00003052 locus:lmn-1 Intermediate filament proteins (2 domains) status:Confirmed UniProt:Q21443 protein_id:CAB09411.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE15746 WBGene00003052 locus:lmn-1 Intermediate filament proteins (2 domains) status:Confirmed UniProt:Q21443 protein_id:CAB09411.1| [wormORF-contam.fasta]
  • Lamin-1 (CeLam-1) (Ce-lamin) [nr-271106-contam.fasta]
  • Hypothetical protein DY3.2 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • nuclear LaMiN family member (lmn-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE15746 WBGene00003052 locus:lmn-1 status:Confirmed UniProt:Q21443 protein_id:CAB09411.1 Lamin-1 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 566 amino acids

    Gene Ontology:
    Cellular Component: nuclear envelope [IDALink to PubMed articleLink to PubMed article]
    lamin filament [ISSLink to PubMed article]
    nucleoplasm [IDALink to PubMed article]
    Biological Process: germ cell development [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    post-embryonic body morphogenesis [IMPLink to PubMed articleLink to PubMed article]
    protein localization [IMPLink to PubMed article]
    chromosome segregation [IMPLink to PubMed article]
    nucleus organization [IMPLink to PubMed article]
    mitotic cell cycle [IMPLink to PubMed article]
    reproduction [IMPLink to PubMed article]
    chromosome decondensation [IMPLink to PubMed article]
    nuclear pore organization [IMPLink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    pronuclear envelope synthesis [IMPLink to PubMed article]
    Molecular Function: structural molecule activity [IEALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSRKGTRSS RIVTLERSAN SSLSNNGGGD DSFGSTLLET SRLQEKDHLT SLNSRLATYI  60
   61 DKVRQLEQEN NRLQVQIRDI EVVEKKEKSN LADRFEAEKA RLRRALDSAQ DELAKYRIEY 120
  121 DAAKVEVKKL KPQVEKLERE LAGAEEQALH AQSIADQSQA KQKTLQARND KLVVENDDLK 180
  181 KQNITLRDTV EGLKKAVEDE TLLRTAANNK IKALEEDLAF ALQQHKGELE EVRHKRQVDM 240
  241 TTYAKQINDE YQSKLQDQIE EMRAQFKNNL HQNKTAFEDA YKNKLNAARE RQEEAVSEAI 300
  301 HLRARVRDLE TSSSGNASLI ERLRSELDTL KRSFQEKLDD KDARIAELNQ EIERMMSEFH 360
  361 DLLDVKIQLD AELKTYQALL EGEEERLNLT QEAPQNTSVH HVSFSSGGAS AQRGVKRRRV 420
  421 VDVNGEDQDI DYLNRRSKLN KETVGPVGID EVDEEGKWVR VANNSEEEQS IGGYKLVVKA 480
  481 GNKEASFQFS SRMKLAPHAS ATVWSADAGA VHHPPEVYVM KKQQWPIGDN PSARLEDSEG 540
  541 DTVSSITVEF SESSDPSDPA DRCSIM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)
    View Run hcp-2 hcp2 ip from december Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..83] deduced N/A No confident structure predictions are available.
    2 View Details [84..136] PSI-BLAST 9.09691 Tropomyosin
    3 View Details [137..480] PSI-BLAST 16.39794 Heavy meromyosin subfragment
    4 View Details [481..566] PSI-BLAST 32.39794 Lamin A/C globular tail domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • structural molecule activity
    		•  2.40638781086824 bayes_pls_golite062009
  • binding
    		•  2.29024114419453 bayes_pls_golite062009
  • protein binding
    		•  2.1850626714936 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle