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Protein Overview: trm-1

General Information:
Name(s) found: trm-1 / CE15201 [WormBase]
Description(s) found:
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  • WBGene00006613 locus:trm-1 tRNA (guanine(26)-N(2))-dimethyltransferase status:Confirmed UniProt:Q23270 protein_id:CAB00881.1 [WormBase]
  • gi|4249621|gb|AAD13737.1| N2,N2-dimethylguanosine tRNA methyltransferase [Caenorhabditis elegans] [NCBI NR]
  • gi|3881410|emb|CAB00881.1| C. elegans protein ZC376.5, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|17564890|ref|NP_506513.1| TRNA Methylase family member (trm-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|12230760|sp|Q23270.1|TRM1_CAEEL RecName: Full=N(2),N(2)-dimethylguanosine tRNA methyltransferase; AltName: Full=tRNA(guanine-26,N(2)-N(2)) methyltransferase; AltName: Full=tRNA 2,2-dimethylguanosine-26 methyltransferase; AltName: Full=tRNA(m(2,2)G26)di [NCBI NR]
  • pir||T43053 N2,N2-dimethylguanosine tRNA methyltransferase (EC 2.1.1.-) - Caenorhabditis elegans [NCBI NR]
  • tRNA (guanine(26)-N(2))-dimethyltransferase OS=Caenorhabditis elegans GN=trm-1 PE=1 SV=1 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE15201 WBGene00006613 locus:trm-1 N2,N2-dimethylguanosine tRNA methyltransferase status:Confirmed SW:Q23270 protein_id:CAB00881.1 [wormpep150.fasta]
  • 15201 WBGene00006613 locus:trm-1 N2,N2-dimethylguanosine tRNA methyltransferase status:Confirmed SW:Q23270 protein_id:CAB00881.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • TRNA Methylase (58.3 kD) (trm-1) [Caenorhabditis elegans]gi|3881410|emb|CAB00881.1| Hypothetical protein ZC376.5 [Caenorhabditis elegans]gi|4249621|gb|AAD13737.1| N2,N2-dimethylguanosine tRNA methyltransferase [Caenorhabditis elegans]gi|11359792|pir||T [nrdb_11152004_Chlamydomonas]
  • locus:trm-1 N2,N2-dimethylguanosine tRNA methyltransferase status:Confirmed SW:Q23270 protein_id:CAB00881.1 [wormpep115.fasta.reversed]
  • CE15201 locus:trm-1 N2,N2-dimethylguanosine tRNA methyltransferase status:Confirmed SW:Q23270 protein_id:CAB00881.1 [wormpep80.hongbin]
  • CE15201 WBGene00006613 locus:trm-1 N2,N2-dimethylguanosine tRNA methyltransferase status:Confirmed UniProt:TRM1_CAEEL protein_id:CAB00881.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE15201 WBGene00006613 locus:trm-1 N2,N2-dimethylguanosine tRNA methyltransferase status:Confirmed UniProt:TRM1_CAEEL protein_id:CAB00881.1| [wormORF-contam.fasta]
  • Hypothetical protein ZC376.5 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • N(2),N(2)-dimethylguanosine tRNA methyltransferase (tRNA(guanine-26,N(2)-N(2)) methyltransferase) (tRNA 2,2-dimethylguanosine-26 methyltransferase) (tRNA(m(2,2)G26)dimethyltransferase) [nr-271106-contam.fasta]
  • TRNA Methylase family member (trm-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • N2,N2-dimethylguanosine tRNA methyltransferase [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE15201 WBGene00006613 locus:trm-1 N2,N2-dimethylguanosine tRNA methyltransferase status:Confirmed UniProt:Q23270 protein_id:CAB00881.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • CE15201 WBGene00006613 locus:trm-1 status:Confirmed UniProt:Q23270 protein_id:CAB00881.1 tRNA (guanine(26)-N(2))-dimethyltransferase [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 526 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: tRNA processing [IEALink to PubMed article]
    Molecular Function: RNA binding [IEALink to PubMed article]
    tRNA (guanine-N2-)-methyltransferase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTENVNSSGD SAIKSEDKEE VTVIQEGQAK VGFHGPVFYN PVQEFNRDLT VTVLRQFSAD  60
   61 HQKWAEEQKQ LKTEEEPPKK KNKLAINEDG KIRILDALSA SGLRALRFSK EVPNVGFIMA 120
  121 NDFSDNAVAS IQENVKLNGV EDIVEAHFGD AVMTMMEHRG IDKRFHAVDL DPYGTASTFL 180
  181 DSAVQCVADR GILMVTCTDM AVLCGNTPEA CYNKYDAVTT RMKCCHEVGL RILLRAIDSA 240
  241 ANRYTRYIEP LVSISVDFYV RVFVRVHTGA FQAKQSGTKV GTVLVCSGCH SMEPLVLLKR 300
  301 GEGNQQSKYS IPTVRHSISG PGNRCIHCLL PLHQIGPIYL APIHSKPFVT SLLERLKSTP 360
  361 EAERLGTHGR LQGVLTMVNE ELDDVLYYEH NQMANVVKVS VPKSQSVRSA ILNAGFKVSG 420
  421 SHCNPRAIKT NAPMHLLWDI YRQVAKDTSV DREKRLAKES AGYHILGQPI TNTVNFTLHP 480
  481 GAIEQAKKEN LVRFQCNKGK NWGPRQKAKG SVNSTKAGFQ LTEHKE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..450] PSI-BLAST 72.221849 No description for 2dulA was found.
    2 View Details [451..526] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • methyltransferase activity
    		•  4.15445027778357 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  4.07806017452628 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  4.07153733729662 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  3.92746815303714 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  3.39429041855776 bayes_pls_golite062009
  • RNA methyltransferase activity
    		•  3.07428840534971 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  2.99461585647365 bayes_pls_golite062009
  • tRNA methyltransferase activity
    		•  2.5931020126592 bayes_pls_golite062009
  • tRNA (guanine) methyltransferase activity
    		•  2.44201549586712 bayes_pls_golite062009
  • arginine N-methyltransferase activity
    		•  2.41876112831625 bayes_pls_golite062009
  • protein-arginine N-methyltransferase activity
    		•  2.41876112831625 bayes_pls_golite062009
  • DNA-methyltransferase activity
    		•  2.39581687084457 bayes_pls_golite062009
  • rRNA methyltransferase activity
    		•  2.29640050660273 bayes_pls_golite062009
  • transferase activity
    		•  2.22303238506686 bayes_pls_golite062009
  • histone-arginine N-methyltransferase activity
    		•  2.04296107639729 bayes_pls_golite062009
  • tRNA (cytosine)-methyltransferase activity
    		•  1.88889414729709 bayes_pls_golite062009
  • tRNA (cytosine-5-)-methyltransferase activity
    		•  1.88889414729709 bayes_pls_golite062009
  • protein-arginine omega-N monomethyltransferase activity
    		•  1.66871163498737 bayes_pls_golite062009
  • tRNA (guanine-N2-)-methyltransferase activity
    		•  1.5444293148467 bayes_pls_golite062009
  • tRNA (adenine-N1-)-methyltransferase activity
    		•  1.29759910099835 bayes_pls_golite062009
  • tRNA (adenine)-methyltransferase activity
    		•  1.29759910099835 bayes_pls_golite062009
  • catalytic activity
    		•  1.25333584501255 bayes_pls_golite062009
  • histone methyltransferase activity (H4-R3 specific)
    		•  1.1103522853299 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.914549843668268 bayes_pls_golite062009
  • protein-arginine omega-N asymmetric methyltransferase activity
    		•  0.89325812193225 bayes_pls_golite062009
  • DNA binding
    		•  0.86027591375666 bayes_pls_golite062009
  • site-specific DNA-methyltransferase (adenine-specific) activity
    		•  0.703178429468566 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.616949327277483 bayes_pls_golite062009
  • rRNA (adenine) methyltransferase activity
    		•  0.533090627724779 bayes_pls_golite062009
  • rRNA (adenine-N6,N6-)-dimethyltransferase activity
    		•  0.455449410561251 bayes_pls_golite062009
  • RNA binding
    		•  0.417524996559564 bayes_pls_golite062009
  • binding
    		•  0.383237930789959 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle