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Protein Overview: pcn-1

General Information:
Name(s) found: pcn-1 / CE14512 [WormBase]
Description(s) found:
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  • WBGene00003955 locus:pcn-1 Proliferating cell nuclear antigen status:Confirmed UniProt:O02115 protein_id:CCD66765.1 [WormBase]
  • pir||T28761 hypothetical protein W03D2.4 - Caenorhabditis elegans [NCBI NR]
  • sp|O02115|PCNA_CAEEL Proliferating cell nuclear antigen (PCNA) [NCBI NR]
  • ref|NP_500466.1| proliferating Cell Nuclear Antigen homolog (29.0 kD) (pcn-1) [Caenorhabditis elegans] [NCBI NR]
  • Proliferating cell nuclear antigen OS=Caenorhabditis elegans GN=pcn-1 PE=1 SV=3 [Swiss-Prot]
  • [wormpep67.fasta]
  • 14512 WBGene00003955 locus:pcn-1 cyclin status:Confirmed SW:O02115 protein_id:AAC48257.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • proliferating Cell Nuclear Antigen homolog (29.0 kD) (pcn-1) [Caenorhabditis elegans]gi|7508883|pir||T28761 hypothetical protein W03D2.4 - Caenorhabditis elegansgi|3334292|sp|O02115|PCNA_CAEEL Proliferating cell nuclear antigen (PCNA) [nrdb_11152004_Chlamydomonas]
  • CE14512 WBGene00003955 locus:pcn-1 cyclin status:Confirmed SW:O02115 protein_id:AAC48257.1 [wormpep132.fasta]
  • locus:pcn-1 cyclin status:Confirmed SW:O02115 protein_id:AAC48257.1 [wormpep115.fasta.reversed]
  • CE14512 locus:pcn-1 cyclin status:Confirmed [wormpep80.hongbin]
  • [wormORF-contam.fasta]
  • CE14512 WBGene00003955 locus:pcn-1 cyclin status:Confirmed UniProt:O02115 protein_id:AAC48257.2 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • CE14512 WBGene00003955 locus:pcn-1 cyclin status:Confirmed UniProt:O02115 protein_id:CCD66765.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE14512 WBGene00003955 locus:pcn-1 status:Confirmed UniProt:O02115 protein_id:CCD66765.1 Proliferating cell nuclear antigen [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 263 amino acids

    Gene Ontology:
    Cellular Component: PCNA complex [IEALink to PubMed article]
    Biological Process: embryonic cleavage [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed article]
    cytokinesis [IMPLink to PubMed article]
    regulation of DNA replication [IEALink to PubMed article]
    reproduction [IMPLink to PubMed article]
    Molecular Function: DNA binding [IEALink to PubMed article]
    DNA polymerase processivity factor activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFEAKLANAG LLKKIVESIK DLVTDAPFDC SETAMSLQAM DSSHVALVSL KLEVGLFDTY  60
   61 RCDRTINLGL SLANMSKALK CANNDDTCML KYEENEGDSI IFTFADPKRD KTQDVTVKMM 120
  121 DIDSEHLGIP DQDYAVVCEM PAGEFQKTCK DLSTFSDSLN ITATKAGIVF TGKGDIGSSV 180
  181 VTYSPSSNTD DETEAVTLEV KDPVNVNFSI KYMNQFTKAT ALSDRVRLSL CNDVPVVVEY 240
  241 PIEENGYLRF YLAPKIDDDE NMD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..263] PSI-BLAST 93.09691 Prolifirating cell nuclear antigen (PCNA)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA polymerase processivity factor activity
    		•  9.9878881203193 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  5.01426276108174 bayes_pls_golite062009
  • DNA polymerase activity
    		•  4.9656505576274 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  3.23598180825386 bayes_pls_golite062009
  • mismatched DNA binding
    		•  2.75713709757781 bayes_pls_golite062009
  • DNA insertion or deletion binding
    		•  2.48680473192192 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.32553487472442 bayes_pls_golite062009
  • DNA binding
    		•  2.24518789437215 bayes_pls_golite062009
  • binding
    		•  1.88302251910664 bayes_pls_golite062009
  • dinucleotide insertion or deletion binding
    		•  1.68153838099672 bayes_pls_golite062009
  • mismatch repair complex binding
    		•  1.6296761041903 bayes_pls_golite062009
  • MutLalpha complex binding
    		•  1.21442872292245 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.14392061238362 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.785542777582287 bayes_pls_golite062009
  • catalytic activity
    		•  0.48077242755678 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.457118392479642 bayes_pls_golite062009
  • protein binding
    		•  0.452894757163315 bayes_pls_golite062009
  • purine-specific mismatch base pair DNA N-glycosylase activity
    		•  0.408841404605319 bayes_pls_golite062009
  • mismatch base pair DNA N-glycosylase activity
    		•  0.387975438046246 bayes_pls_golite062009
  • transferase activity
    		•  0.345371754708312 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle