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Protein Overview: twk-22

General Information:
Name(s) found: twk-22 / CE06337 [WormBase]
Description(s) found:
Found 19 descriptions.
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  • WBGene00006675 locus:twk-22 status:Partially_confirmed UniProt:Q22043 protein_id:CAA93876.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 757 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEALink to PubMed article]
    integral to membrane [IEALink to PubMed article]
    Biological Process: potassium ion transport [IEALink to PubMed article]
    Molecular Function: potassium channel activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDVPTFILHS ADTESVISDD DSSYYFDGSV EQLTLRNQEY SDDNRMQRRA PIRRKSALDD  60
   61 DQTSQAMKLL EKYIRKKYRH SVIFSQDSAD IEQSSTPVGH TQSACQFSRN LTPEQRNGFY 120
  121 STPLGPAPSE YHFPPGSPQF RESTIREEFK QQYRETWGHW FVRVGKFLYK LLGIQYMLLA 180
  181 LMILGYACLG GYIFLTLEYD QQQLDLEVEK QVRLSESTLL AENLLKYLKQ WNCGQSNENR 240
  241 CLELITKAFI ERSIKVERDI RGEGWRYGNL ACKTNLGRVA TIIYGLIGIP LMLFVLKIFG 300
  301 EHSIKWAQKV RYSIRRCVKR CFRRSKLKRA STIESVASDE MPCEESGISE DEEQITTFPV 360
  361 KWALFIVFFF MVVCSLIVSF WEKWDFLTAF YFFFVSLSTI GFGDVIPEHP RTACGNGLLE 420
  421 IKICYISVMI NGALKMSGDA VNFPRFLNTK IQLTEKFQLY LISALFVLYF VGLALFSMVY 480
  481 AILQERVENQ YMWALELIDQ EYQENQKQDP DDHLEIPTIL PENAAGMEGW TNTIGKMVSQ 540
  541 NPVRWRAKNS AYSMENMPDR PISERRFSVL SPGEAPQAPP PVLGTFMLHS LSVKKKLLAR 600
  601 SESILNRTGS PWPHAAEMNR PKEATRLGEP SALRVSAPNL TISGGNRSPS GGALSVITEA 660
  661 SDEDTRHFKK HRRPLAKTVS TDGTVSNHGS AESLDQVMDE LQLESHDQAV TPKPYRDPTT 720
  721 STRFRKRDET VVSRAEKMPL SPNEVLEEED EDENGDT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..515] PSI-BLAST 64.221849 Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
    2 View Details [516..576] PSI-BLAST 3.39794 HCN2J 443-645 in the presence of cGMP
    3 View Details [577..757] MSA 8.135997 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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