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View Structure Prediction Details

Protein: twk-22
Organism: Caenorhabditis elegans
Length: 757 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for twk-22.

Description E-value Query
Range
Subject
Range
KCNB2_MOUSE - Potassium voltage-gated channel subfamily B member 2 OS=Mus musculus GN=Kcnb2 PE=2 SV=1
339.0 [0..48] [751..38]

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Predicted Domain #1
Region A:
Residues: [1-515]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDVPTFILHS ADTESVISDD DSSYYFDGSV EQLTLRNQEY SDDNRMQRRA PIRRKSALDD  60
   61 DQTSQAMKLL EKYIRKKYRH SVIFSQDSAD IEQSSTPVGH TQSACQFSRN LTPEQRNGFY 120
  121 STPLGPAPSE YHFPPGSPQF RESTIREEFK QQYRETWGHW FVRVGKFLYK LLGIQYMLLA 180
  181 LMILGYACLG GYIFLTLEYD QQQLDLEVEK QVRLSESTLL AENLLKYLKQ WNCGQSNENR 240
  241 CLELITKAFI ERSIKVERDI RGEGWRYGNL ACKTNLGRVA TIIYGLIGIP LMLFVLKIFG 300
  301 EHSIKWAQKV RYSIRRCVKR CFRRSKLKRA STIESVASDE MPCEESGISE DEEQITTFPV 360
  361 KWALFIVFFF MVVCSLIVSF WEKWDFLTAF YFFFVSLSTI GFGDVIPEHP RTACGNGLLE 420
  421 IKICYISVMI NGALKMSGDA VNFPRFLNTK IQLTEKFQLY LISALFVLYF VGLALFSMVY 480
  481 AILQERVENQ YMWALELIDQ EYQENQKQDP DDHLE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 64.221849
Match: 2a79B
Description: Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [516-576]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPTILPENAA GMEGWTNTIG KMVSQNPVRW RAKNSAYSME NMPDRPISER RFSVLSPGEA  60
   61 P

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.39794
Match: 1q3eA
Description: HCN2J 443-645 in the presence of cGMP
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [577-757]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QAPPPVLGTF MLHSLSVKKK LLARSESILN RTGSPWPHAA EMNRPKEATR LGEPSALRVS  60
   61 APNLTISGGN RSPSGGALSV ITEASDEDTR HFKKHRRPLA KTVSTDGTVS NHGSAESLDQ 120
  121 VMDELQLESH DQAVTPKPYR DPTTSTRFRK RDETVVSRAE KMPLSPNEVL EEEDEDENGD 180
  181 T

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle