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Protein Overview: unc-18

General Information:
Name(s) found: unc-18 / CE04449 [WormBase]
Description(s) found:
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  • WBGene00006757 locus:unc-18 Putative acetylcholine regulator unc-18 status:Partially_confirmed UniProt:P34815 protein_id:CCD67916.1 [WormBase]
  • gi|71988800|ref|NP_001024608.1| UNCoordinated family member (unc-18) [Caenorhabditis elegans] [NCBI NR]
  • pir||S36747 probable acetylcholine regulator unc-18 - Caenorhabditis elegans [NCBI NR]
  • gi|34610403|gb|AAQ81273.1| Uncoordinated protein 18, isoform c [Caenorhabditis elegans] [NCBI NR]
  • gi|247392|gb|AAB21818.1| putative acetylcholine regulator [Caenorhabditis elegans] [NCBI NR]
  • gi|116242841|sp|P34815.3|UNC18_CAEEL RecName: Full=Putative acetylcholine regulator unc-18; AltName: Full=Uncoordinated protein 18 [NCBI NR]
  • Putative acetylcholine regulator unc-18 OS=Caenorhabditis elegans GN=unc-18 PE=2 SV=3 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE04449 WBGene00006757 locus:unc-18 status:Partially_confirmed TR:Q7JNZ2 protein_id:AAQ81273.1 [wormpep150.fasta]
  • 04449 WBGene00006757 locus:unc-18 status:Partially_confirmed protein_id:AAQ81273.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • Uncoordinated protein 18, isoform c [Caenorhabditis elegans]gi|480359|pir||S36747 probable acetylcholine regulator unc-18 - Caenorhabditis elegansgi|247392|gb|AAB21818.1| putative acetylcholine regulator [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • CE04449 WBGene00006757 locus:unc-18 status:Partially_confirmed protein_id:AAQ81273.1 [wormpep132.fasta]
  • 04449 WBGene00006757 locus:unc-18 status:Partially_confirmed TR:Q7JNZ2 protein_id:AAQ81273.1 [wormpep150-phg-orf-ecoli-rand.fasta]
  • locus:unc-18 status:Partially_confirmed TN:AAQ81273 protein_id:AAQ81273.1 [wormpep115.fasta.reversed]
  • CE04449 WBGene00006757 locus:unc-18 status:Partially_confirmed UniProt:UNC18_CAEEL protein_id:AAQ81273.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE04449 WBGene00006757 locus:unc-18 status:Partially_confirmed UniProt:UNC18_CAEEL protein_id:AAQ81273.1| [wormORF-contam.fasta]
  • putative acetylcholine regulator [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Uncoordinated protein 18, isoform c [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Putative acetylcholine regulator unc-18 (Uncoordinated protein 18) [nr-271106-contam.fasta]
  • UNCoordinated family member (unc-18) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE04449 WBGene00006757 locus:unc-18 status:Partially_confirmed SW:P34815 protein_id:AAQ81273.1 [WormBase_C-elegans_wp180_08-19-2007_reversed.fasta]
  • CE04449 WBGene00006757 locus:unc-18 status:Partially_confirmed UniProt:P34815 protein_id:AAQ81273.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE04449 WBGene00006757 locus:unc-18 status:Partially_confirmed UniProt:P34815 protein_id:CCD67916.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE04449 WBGene00006757 locus:unc-18 status:Partially_confirmed UniProt:P34815 protein_id:CCD67916.1 Putative acetylcholine regulator unc-18 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 673 amino acids

    Gene Ontology:
    Cellular Component: axon [IDALink to PubMed article]
    Biological Process: synaptic vesicle docking during exocytosis [IMPLink to PubMed article]
    vesicle-mediated transport [IEALink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    positive regulation of neurotransmitter secretion [IMPLink to PubMed article]
    vesicle docking during exocytosis [IEALink to PubMed article]
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQNVKHSYLA CSSSSCCQFF SLFLSLCHAE HQIQTLSPSF AYTLLIFALL VSDKSEIALL  60
   61 SRHTHTYIFL PISSVHPSLE LLPFVVFMHM RKLLNDVIRP LKKGDGRSAW NVLIVDTLAM 120
  121 RMLSSCCKMH NIMEEGITIV EDLNKRREPL PTLEAIYLIA PTAESIDKLI QDYCARNLYK 180
  181 CAHVFFTEAC SDQLFSTLSK SAAARFIKTL KEINIAFTPY ESQVFNLDSP DTFFLYYNAQ 240
  241 KQGGLTSNLE RIAEQIATVC ATLGEYPSLR YRADFERNVE LGHLVEQKLD AYKADDPSMG 300
  301 EGADKARSQL IIIDRGYDAI TPLLHELTLQ AMCYDLLGIE NDVYKYETGG SDENLEKEVL 360
  361 LDENDDLWVE MRHKHIAVVS QEVTKNLKKF SESKGNKGTM DSKSIKDLSM LIKRMPQHKK 420
  421 ELNKFSTHIS LAEECMKQYQ QGVDKLCKVE QDLSTGIDAE GERVRDAMKL MVPLLIDPAV 480
  481 RCEDRLRLIL LYILSKNGIT DENLNKLLQH ANISMADKET ITNAAYLGLN IVTDTGRKKT 540
  541 WTPTKKERPH EQVYQSSRWV PVIKDIIEDA IDERLDTKHF PFLAGRQVNQ GYRAPASARY 600
  601 GQWHKERGQQ SNYRSGPRLI IYIIGGVTFS EMRACYEVTA ARKPWEVVIG SDRIITPDKF 660
  661 LTNLRDLNKP RDI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..79] deduced N/A No confident structure predictions are available.
    2 View Details [80..673] PSI-BLAST 159.0 Neuronal Sec1, NSec1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • SNARE binding
    		•  4.56428593085019 bayes_pls_golite062009
  • syntaxin binding
    		•  3.46044132736061 bayes_pls_golite062009
  • binding
    		•  2.7837022903231 bayes_pls_golite062009
  • protein binding
    		•  2.77285532000616 bayes_pls_golite062009
  • syntaxin-1 binding
    		•  0.269372794919901 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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