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Protein Overview: pme-2

General Information:
Name(s) found: pme-2 / CE01539 [WormBase]
Description(s) found:
Found 23 descriptions.
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  • WBGene00004050 locus:pme-2 Poly(ADP-ribose) polymerase pme-2 status:Confirmed UniProt:Q09525 protein_id:CAA87379.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 538 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    Biological Process: protein amino acid ADP-ribosylation [IEALink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    Molecular Function: NAD+ ADP-ribosyltransferase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIINDENGR GYKVHLCKTN IAQNNNKFYD MELLDEGGDF IVKLINGRIG YRGVTQLKDF  60
   61 DDLDRAKKFF ESKFYEKTHL HWEERDDEPV PNKYAVVELA TNARQTEKEV KKEEPEPEPK 120
  121 VDEKNTRGRK KRGIVKEKKE IKKEEEPVEE VNEKLKELMK CICDEDVHLG LLKQLKFNEA 180
  181 FGRPIDCLSL AQLTTGYEIL SKIEESIGGK SARRSTRGRP RVADRVLAVK SDGPSLHDIN 240
  241 KYYSLIPHSF GFCVPPKIDS HAKIQAEREL LDALKGSIEA SLELKDLKKT ASSKDIYQRL 300
  301 YERLPCHLEP VSEEIAGKIG DCLAMRGPTH CYKLSLIDAF ELKDPNEIPT EAPVEVQEVP 360
  361 KKRGRKSTKT AAPTVPPPTT KRLLWHGTRV TNVFSILMNG LQFPVGDRCG LMFGNGVYFA 420
  421 NVPTKSANYC CPEASKRVFM LLCEVETANP LVLYESEIDA DEKMEKAKKT SVYAAGKHTP 480
  481 RDTVEINGIP AFKSNLETIE EETRLLYDEY VMFNKEHFKI KYVVEVKVDR LTAKEMMA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..145] PSI-BLAST 24.221849 Solution structure of WGR domain of poly(ADP-ribose) polymerase-1
    2 View Details [146..538] PSI-BLAST 93.30103 Crystal structure of catalytic domain of human poly(ADP-ribose) polymerase with a novel inhibitor

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • NAD+ ADP-ribosyltransferase activity
    		•  7.15093533922724 bayes_pls_golite062009
  • NAD(P)+-protein-arginine ADP-ribosyltransferase activity
    		•  2.57756389034544 bayes_pls_golite062009
  • binding
    		•  1.5526011325617 bayes_pls_golite062009
  • transferase activity
    		•  1.5222353301058 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.901890891144085 bayes_pls_golite062009
  • catalytic activity
    		•  0.886617552734979 bayes_pls_golite062009
  • DNA binding
    		•  0.850361767185031 bayes_pls_golite062009
  • protein binding
    		•  0.610837485187136 bayes_pls_golite062009
  • NAD+ nucleosidase activity
    		•  0.309947239058532 bayes_pls_golite062009
  • transferase activity, transferring pentosyl groups
    		•  0.29605207876765 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.209002662548996 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.147630885386744 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  0.0346323577656257 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle