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Protein Overview: ent1

General Information:
Name(s) found: ent1 / SPCC162.07 [Sanger Pombe]
Description(s) found:
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  • pir||T41024 hypothetical protein SPCC162.07 - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|62900127|sp|O74423.1|ENT1_SCHPO RecName: Full=Epsin-1 [NCBI NR]
  • gi|3218397|emb|CAA19587.1| epsin [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19075737|ref|NP_588237.1| epsin [Schizosaccharomyces pombe] [NCBI NR]
  • epsin [Sanger Pombe]
  • Epsin-1 OS=Schizosaccharomyces pombe GN=ent1 PE=1 SV=1 [Swiss-Prot]
  • ENTH DOMAIN PROTEIN; ENDOCYTOCIS OR CYTOSKELETAL MACHINERY: O74423; [pompepVF.fasta]
  • PROTEIN WITH ENTH DOMAIN; ENDOCYTOCIS OR CYTOSKELETAL MACHINERY: O74423; [pompepV13]
  • Hypothetical protein [pompep4896]
  • |||ENTH domain protein [pompepnew.fasta]
  • SPCC162.07 protein [4896.FASTAC]
  • |||epsin|Schizosaccharomyces pombe|chr 3|||Manual [pombe041504.fasta]
  • hypothetical protein [Schizosaccharomyces pombe]gi|3218397|emb|CAA19587.1| SPCC162.07 [Schizosaccharomyces pombe]gi|7491824|pir||T41024 hypothetical protein SPCC162.07 - fission yeast (Schizosaccharomyces pombe) [nrdb_11152004_Chlamydomonas]
  • (O74423) Hypothetical protein [pompep4896_normal_reversed]
  • |ent1||epsin|Schizosaccharomyces pombe|chr 3|||Manual [pombe030305.revfasta]
  • hypothetical protein SPCC162.07 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • Epsin-1 [nr-271106-contam.fasta]
  • SPCC162.07 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • Epsin-1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ent1 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 706 amino acids

    Gene Ontology:
    Cellular Component: extrinsic to membrane [IEA]
    actin cortical patch [IDALink to PubMed article]
    Biological Process: regulation of catalytic activity [ICLink to PubMed article]
    actin filament organization [IMPLink to PubMed article]
    endocytosis [IMPLink to PubMed article]
    actin cortical patch assembly [ISSLink to PubMed article]
    Molecular Function: phosphatidylinositol-4,5-bisphosphate binding [IDALink to PubMed article]
    ubiquitin binding [ISSLink to PubMed article]
    GTPase activator activity [TASLink to PubMed article]
    clathrin binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAFSALAYNL LAKNFSKGYT DTQIKVRNAT TNDSWGPSGT AMAEIAELTY DQNEMLEVMD  60
   61 IIDRRLNDKG KNWRHVFKSL SLLEYCLHNG SENVVRWAKD NIYIITTLRE FVYVDDNGHD 120
  121 QGQNVRTKAK EITSLLEDEH ALKEARGDSR ERDRDRDRTR SSRFDDDDDD RAPYEESRLS 180
  181 RAPSRASRYD DDDRDHRSRR RSRSRRPGRS RSRRRSRRPS PSAEHNSAEE NDPELQRVIE 240
  241 ESKRQAEEDA KRRNMANDSE AELQKAIQLS KEEDEARQRH QREREQQEQA FMGNQQNAYQ 300
  301 PVDFFGNPVQ PQPTGFLQQQ PTGFIRPQNT GFVQPQYTGF VQPQHTGFVQ PQATGFMQPQ 360
  361 RTGFVQPQAT GFVQPQATGF VQPQATGFMQ PQRTGFVQPQ ATGFMQPQRT GFVQPQATGF 420
  421 MQPQRTGFVQ PQATGFIQPQ RTGFVQPQQN GFFNPQPTGY MQPQRTGMMQ PQRTGFSQPF 480
  481 ESNNPFPVMQ PQRTGFGQTP NAPMMAPNHT GYVHPQPTGL QRQTTGYTGN NNPYSRPLQS 540
  541 QSTGILQQQQ QQSAPRLEPT KTGSNNPFAQ FSNLPSQSTA PATKPMKPVR TGDDRFSNIA 600
  601 QAISTGNPMG TDSFGNIGLT RVPTQHTGSK FTNSAGQTIQ AQATGNTHNP FQSQQATGYY 660
  661 KQPMQQQQNM QQPYYNQQNY NYQNQQPMQG MQQQSMQPQV GSLIDL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..155] PSI-BLAST 80.39794 Epsin 1
    2 View Details [156..280] FFAS03 1.31 No description for 2j63A was found.
    3 View Details [281..356] Pfam 19.356547 No description for PF08226.2 was found. No confident structure predictions are available.
    4 View Details [357..557] PSI-BLAST 3.69897 Sec24
    5 View Details [558..706] MSA 5.271997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • clathrin binding
    		•  2.70535896247543 bayes_pls_golite062009
  • binding
    		•  2.34501465852339 bayes_pls_golite062009
  • protein binding
    		•  1.97365365208963 bayes_pls_golite062009
  • phosphatidylinositol-4,5-bisphosphate binding
    		•  1.20269437433936 bayes_pls_golite062009
  • phosphoinositide binding
    		•  0.87586037360588 bayes_pls_golite062009
  • phospholipid binding
    		•  0.84481265656013 bayes_pls_golite062009
  • lipid binding
    		•  0.176990783274449 bayes_pls_golite062009
  • GTPase binding
    		•  0.0887270623721197 bayes_pls_golite062009
  • small GTPase binding
    		•  0.0268749201897704 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle