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Protein Overview: mnl1

General Information:
Name(s) found: mnl1 / SPAC23A1.04c [Sanger Pombe]
Description(s) found:
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  • pir||T38224 probable glycosyl hydrolase - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|74582998|sp|O94726.2|MNL1_SCHPO RecName: Full=ER degradation-enhancing alpha-mannosidase-like protein 1; Flags: Precursor [NCBI NR]
  • gi|5777718|emb|CAA16978.2| alpha mannosidase-like protein [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19115346|ref|NP_594434.1| alpha mannosidase-like protein [Schizosaccharomyces pombe 972h-] [NCBI NR]
  • alpha mannosidase-like protein [Sanger Pombe]
  • ER degradation-enhancing alpha-mannosidase-like protein 1 OS=Schizosaccharomyces pombe GN=mnl1 PE=2 SV=2 [Swiss-Prot]
  • PUTATIVE GLYCOSYL HYDROLASE: O94726; [pompepVF.fasta]
  • Putative glycosyl hydrolase [pompep4896]
  • |||glycosyl hydrolase family 47 [pompepnew.fasta]
  • SPAC23A1.04c protein [4896.FASTAC]
  • |||glycosyl hydrolase family 47|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • putative glycosyl hydrolase [Schizosaccharomyces pombe]gi|5777718|emb|CAA16978.2| SPAC23A1.04c [Schizosaccharomyces pombe]gi|7492608|pir||T38224 probable glycosyl hydrolase - fission yeast (Schizosaccharomyces pombe) [nrdb_11152004_Chlamydomonas]
  • (O94726) Putative glycosyl hydrolase [pompep4896_normal_reversed]
  • |mnl1||alpha mannosidase-like protein|Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • SPAC23A1.04c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPAC23A1.04c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • |mnl1||alpha mannosidase Mnl1 |Schizosaccharomyces pombe|chr 1|||Manual [Other_S_Pombe_12-15-2011_reversed.fasta]
  • ER degradation-enhancing alpha-mannosidase-like protein 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=mnl1 PE=3 SV=2 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 787 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum lumen [IEA]
    membrane [IEA]
    cytosol [IDALink to PubMed article]
    endoplasmic reticulum [ISSLink to PubMed article]
    Biological Process: glycoprotein catabolic process [ISSLink to PubMed article]
    protein deglycosylation [ISSLink to PubMed article]
    ER-associated protein catabolic process [ISSLink to PubMed article]
    response to unfolded protein [IEA]
    Molecular Function: calcium ion binding [IEA]
    [NOT]mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [TASLink to PubMed article]
    carbohydrate binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSLHSIFCV CLILLCIFKE NSIVGAINSA RMVELRETSR RLFYHGYNNY MQFAFPNDEL  60
   61 APLSCEGLGP DYENPNNIGV NDVRGDYLLT LVDVLDTLVV LGDREGFQDA VDKVIHHINF 120
  121 ERDTKVQVFE ATIRILGGLL SSHIFASEEK YGFQIPLYKG ELLTLATELA ERLLPAFRTP 180
  181 TGIPFARINL MKGVAYREVT ENCAAAASSL VLEFSMLTAL TGNNKFKASA ENAFFSVWKR 240
  241 RSGIGLLGNS IDVLSGRWIY PVSGVGAGID SFYEYAFKSY IFLGDPRYLE VWQKSLESLR 300
  301 HYTASLNEYY YQNVYSANGM VMSRWVDSLS AYFPGLLVLA GELELAKKMH LYYFSIYLKF 360
  361 GQLPERYNLY TKSIELNGYP LRPEFAESTY YLYRATKDVF YLHVGELLLS NIENHLWTPC 420
  421 GFAAVENLEK YTLSNRMESF FLSETLKYLF LLFDDDNPIH RSHHDFIFTT EGHLFPVTNQ 480
  481 TRLSTSQRIY DGGEVCVAED YDRSKWPMLY SLIASRDDYD YVSHLVGIDN KAIPSYLIDP 540
  541 SGVCKRPEYS DGFELLYGSA LVSPIKSVER VTNNVYISDI IGNKLKFVQK EGSNSLFLYT 600
  601 AGAESINEND TVFLTDPDYE TFTRPDALYF DRTIAQLENP NSGQKTFGKF LQFDNDNSLP 660
  661 SKVFKTVLLN NSMCQKPSDT LDKDTAYIAP LGNCSWVQQA KNTNKAGLLI LITDGEFINP 720
  721 LENIHSQNSL FNWVKPYIPP TILLKNENNF VSKWANVSVR QSDFDAPSYF QGTPVSNLYL 780
  781 CLKCINS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..483] PSI-BLAST 176.0 Structure of mouse Golgi alpha-1,2-mannosidase IA reveals the molecular basis for substrate specificity among Class I enzymes (family 47 glycosidases)
    2 View Details [484..680] deduced N/A No confident structure predictions are available.
    3 View Details [681..787] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • mannosyl-oligosaccharide mannosidase activity
    		•  6.03401660757398 bayes_pls_golite062009
  • mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
    		•  5.94478263057567 bayes_pls_golite062009
  • mannosidase activity
    		•  5.20286438265852 bayes_pls_golite062009
  • hydrolase activity, hydrolyzing O-glycosyl compounds
    		•  3.05728424511001 bayes_pls_golite062009
  • hydrolase activity, acting on glycosyl bonds
    		•  2.49671827314842 bayes_pls_golite062009
  • hydrolase activity
    		•  2.48593524259701 bayes_pls_golite062009
  • binding
    		•  1.49199031708525 bayes_pls_golite062009
  • catalytic activity
    		•  1.31873306707813 bayes_pls_golite062009
  • alpha-mannosidase activity
    		•  0.569290872152206 bayes_pls_golite062009
  • cation binding
    		•  0.362242764130218 bayes_pls_golite062009
  • metal ion binding
    		•  0.362242764130218 bayes_pls_golite062009
  • protein binding
    		•  0.36081692928767 bayes_pls_golite062009
  • ion binding
    		•  0.355220167272296 bayes_pls_golite062009
  • calcium ion binding
    		•  0.121126738064555 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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