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Protein Overview: tpp1

General Information:
Name(s) found: tpp1 / SPAC19G12.15c [Sanger Pombe]
Description(s) found:
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  • gi|5101851|emb|CAB45142.1| trehalose-6P phosphatase [Schizosaccharomyces pombe] [NCBI NR]
  • gi|2239209|emb|CAB10126.1| trehalose-6-phosphate phosphatase Tpp1 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|21362995|sp|P78875.2|TPP1_SCHPO RecName: Full=Trehalose-phosphatase; AltName: Full=Trehalose-6-phosphate phosphatase; Short=TPP [NCBI NR]
  • gi|19115342|ref|NP_594430.1| trehalose-6-phosphate phosphatase Tpp1 [Schizosaccharomyces pombe 972h-] [NCBI NR]
  • pir||T43659 trehalose-phosphatase (EC 3.1.3.12) [similarity] - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • trehalose-6-phosphate phosphatase Tpp1 [Sanger Pombe]
  • Trehalose-phosphatase OS=Schizosaccharomyces pombe GN=tpp1 PE=1 SV=2 [Swiss-Prot]
  • TREHALOSE-6P PHOSPHATASE: P78875; [pompepVF.fasta]
  • Trehalose-phosphatase (EC 3.1.3.12) (Trehalose 6-phosphate phosphatase) (TPP) [pompep4896]
  • |tpp1||trehalose-6-phosphate phosphatase (PMID 11004189) [pompepnew.fasta]
  • |tpp1||trehalose-6-phosphate phosphatase (PMID 11004189)|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • |tpp1||trehalose-6-phosphate phosphatase |Schizosaccharomyces pombe|chr 1|||Manual [pompep2242005.fasta]
  • trehalose-6p phosphatase [Schizosaccharomyces pombe]gi|5101851|emb|CAB45142.1| trehalose-6P phosphatase [Schizosaccharomyces pombe]gi|2239209|emb|CAB10126.1| SPAC19G12.15c [Schizosaccharomyces pombe]gi|11281551|pir||T43659 trehalose-phosphatase (EC 3.1 [nrdb_11152004_Chlamydomonas]
  • (P78875) Trehalose-phosphatase (EC 3.1.3.12) (Trehalose 6-phosphate phosphatase) (TPP) [pompep4896_normal_reversed]
  • |tpp1||trehalose-6-phosphate phosphatase Tpp1|Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • Trehalose-phosphatase (Trehalose 6-phosphate phosphatase) (TPP) [nr-271106-contam.fasta]
  • hypothetical protein SPAC19G12.15c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • SPAC19G12.15c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • trehalose-6P phosphatase [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • Trehalose-phosphatase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=tpp1 PE=1 SV=2 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 817 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: cellular response to stress [IEPLink to PubMed article]
    trehalose biosynthetic process [IEA]
    trehalose metabolic process [IMPLink to PubMed article]
    dephosphorylation [ICLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]
    trehalose-phosphatase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVYGKIPST SFEHENTFEL SGDLLDPEEL KSLGVSGRII YVLRHLPFKS SINEETREWD  60
   61 LSGRRGATTM YSSMNWLANS TYWQTTLVGW TGVIPTVSEK EENKDAVTRL DSQDVKRFEE 120
  121 TYSQWNSGER STEYVPVWLP GPEKGSETII NETRSQQSRW LAYAENVIRP LIHYKYWPSS 180
  181 EVDENEEQWW RDYVKMNHAF ADKICEIYKP GDFIIVQDYS LFLVPQLIRN KIDDAVIGFY 240
  241 HHHPFPSSEI ARCFPRRRAI LRSVLGADFI GFEDYSYARH FISCCSRVLD LEIGHDWVNL 300
  301 NGNKVTVRAI TVGIDVPRII RSSGNVSVSE KLEELNKRYE NMKVILGRDR LDELYGVPQK 360
  361 LRSFQRFLRT YPEWRKKVVL IQITISSAFK HPKLLSSIKK LVQAINQEFG TDDYTPVHHV 420
  421 EEQLEPADYF ALLTRADALF INSIREGVSN LALEYVVCQR DRYGMVLLSE FTATSAMLHD 480
  481 VPLINPWDYN ECAEIISNAL STPLERRKMI ERESYKQVTT HTMQSWTSSL IRSLANKLAA 540
  541 TKTDQRIPTL TPEHALSVYS KASKRLFMMD YDGTLTPIVR DPNAAVPSKK LLDNLATLAA 600
  601 DPKNQVWIIS GRDQQFLRNW MDDIKGLGLS AEHGSFVRKP HSTTWINLAE LLDMSWKKEV 660
  661 RRIFQYYTDR TQGSSIEEKR CAMTWHYRKA DPENGAFQAL ECEALLEELV CSKYDVEIMR 720
  721 GKANLEVRPS SINKGGIVKQ ILSSYPEDSL PSFIFCAGDD RTDEDMFRSL HKNTRINKET 780
  781 SFAVTIGSDK KLSIADWCIA DPANVIDILA DLANFTN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..93] deduced N/A No confident structure predictions are available.
    2 View Details [94..549] PSI-BLAST 68.39794 Trehalose-6-phosphate from E. coli bound with UDP-2-fluoro glucose.
    3 View Details [550..817] PSI-BLAST 30.39794 Crystal structure of NYSGRC target T1436: A Hypothetical protein yidA.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
    		•  11.2045941324603 bayes_pls_golite062009
  • glucosyltransferase activity
    		•  8.25064561355471 bayes_pls_golite062009
  • UDP-glucosyltransferase activity
    		•  8.0463972704113 bayes_pls_golite062009
  • trehalose-phosphatase activity
    		•  7.58500038184065 bayes_pls_golite062009
  • transferase activity, transferring hexosyl groups
    		•  3.70184884300914 bayes_pls_golite062009
  • catalytic activity
    		•  2.65148466065976 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  2.62403914335522 bayes_pls_golite062009
  • transferase activity
    		•  2.18054407163329 bayes_pls_golite062009
  • UDP-glycosyltransferase activity
    		•  2.13085705769565 bayes_pls_golite062009
  • binding
    		•  0.86799881302731 bayes_pls_golite062009
  • carbohydrate phosphatase activity
    		•  0.78952375993773 bayes_pls_golite062009
  • UDP-N-acetylglucosamine 2-epimerase activity
    		•  0.690032302126686 bayes_pls_golite062009
  • glycogen phosphorylase activity
    		•  0.607220464589157 bayes_pls_golite062009
  • phosphorylase activity
    		•  0.296436712681472 bayes_pls_golite062009
  • mannosyltransferase activity
    		•  0.253888301381021 bayes_pls_golite062009
    3
    Term Confidence Notes
  • trehalose-phosphatase activity
    		•  3.78859922218487 bayes_pls_golite062009
  • catalytic activity
    		•  1.55296860681783 bayes_pls_golite062009
  • binding
    		•  0.54369553186176 bayes_pls_golite062009
  • hydrolase activity
    		•  0.385402333062566 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.263520144636139 bayes_pls_golite062009
  • phosphatase activity
    		•  0.159899259988948 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  0.103902756538853 bayes_pls_golite062009
  • DNA binding
    		•  0.0142681844140111 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle