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Protein Overview: thi4

General Information:
Name(s) found: thi4 / SPAC23H4.10c [Sanger Pombe]
Description(s) found:
Found 18 descriptions.
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  • thiamine-phosphate dipyrophosphorylase/hydroxyethylthiazole kinase [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 518 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article][ISSLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: phosphorylation [ICLink to PubMed article]
    thiamin biosynthetic process [TASLink to PubMed article]
    Molecular Function: magnesium ion binding [IEA]
    ATP binding [IEA]
    thiamin-phosphate diphosphorylase activity [TASLink to PubMed article]
    hydroxyethylthiazole kinase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKRQIDYSLY LVTSSSLIAP GSTIERQVEE GILGGVTLVQ HREKDISTKC FVERAKRLSE  60
   61 ICKKYDVPFL INDRIDVALA VGADGVHIGQ DDMDCALARK ILGDDAIIGV STNNIEEIEK 120
  121 AAADGADYVG IGSIYETNTK DVKDRLIGIT GLRKILEHVS KMHCQLGTVA IAGLNSSNIQ 180
  181 RVIYLSEANG KRIDGIALVS AIMCSITPRE TAKELRNLIA TPPCFAQARS SLTTPKDLLN 240
  241 QIPAALQKLK DFTPLIHHLT NAVAKNFSAN VTLAAYGSPT MGESYDEVAD FAKAPGALVL 300
  301 NIGILENTKT YIHAAQVNND LARPVILDPV AVGATTARSK VINTLLNYAY YDIIKGNEGE 360
  361 IMNLAGEQGL MRGVDSISQH TLAARITAVH RLAVERRCVV AMSGAVDVIS DGNSTYVIKN 420
  421 GNPLLGQITA SGCSLGSVMG VTASICQNDK LLAAITATLL YNIASELAVE AKNSCGDLLV 480
  481 QGPGTFIPIF VDKLHQLINE TIKGNVDWIE RAKLEKAE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..217] PSI-BLAST 30.69897 Thiamin phosphate synthase
    2 View Details [218..518] PSI-BLAST 38.0 Structure of Hydroxyethylthiazole kinase protein from pyrococcus horikoshii OT3

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • thiamin-phosphate diphosphorylase activity
    		•  5.90476603396884 bayes_pls_golite062009
  • phosphomethylpyrimidine kinase activity
    		•  1.96653650813022 bayes_pls_golite062009
  • catalytic activity
    		•  1.94308403509017 bayes_pls_golite062009
  • transferase activity
    		•  1.66762065968825 bayes_pls_golite062009
  • transferase activity, transferring alkyl or aryl (other than methyl) groups
    		•  0.73172690404654 bayes_pls_golite062009
  • phosphotransferase activity, phosphate group as acceptor
    		•  0.429889467826441 bayes_pls_golite062009
    2
    Term Confidence Notes
  • phosphomethylpyrimidine kinase activity
    		•  3.972577109569 bayes_pls_golite062009
  • phosphotransferase activity, phosphate group as acceptor
    		•  2.29466565429735 bayes_pls_golite062009
  • kinase activity
    		•  2.28531824242987 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.27980720248925 bayes_pls_golite062009
  • transferase activity
    		•  2.15883296431019 bayes_pls_golite062009
  • catalytic activity
    		•  1.74474587246986 bayes_pls_golite062009
  • hydroxyethylthiazole kinase activity
    		•  1.28568044601242 bayes_pls_golite062009
  • thiamin-phosphate diphosphorylase activity
    		•  1.27602595951972 bayes_pls_golite062009
  • carbohydrate kinase activity
    		•  1.12876288824319 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.673555832721854 bayes_pls_golite062009
  • pyridoxal kinase activity
    		•  0.217863391052366 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.60

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle