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Protein Overview: ura3

General Information:
Name(s) found: ura3 / SPAC57A10.12c [Sanger Pombe]
Description(s) found:
Found 21 descriptions.
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  • dihydroorotate dehydrogenase Ura3 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 443 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    membrane [IEA]
    integral to membrane [IEA]
    Biological Process: 'de novo' pyrimidine base biosynthetic process [IDALink to PubMed article]
    UMP biosynthetic process [IEA]
    Molecular Function: dihydroorotate oxidase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYQRSLFRGV AQGLKRSSVR FQSTSSGSSN GNFFLRHWKL LSVIGSFTAG VAIYDMSDVR  60
   61 SFIHGRIEMP LFHAFTTPEF SHRVAILAAS WGITPKDRVA DDPSLAVEVW GKKFCNPIGL 120
  121 AAGFDKQADA ISGLLNFGFS YLEIGSVTPK PQPGNPKPRY FRLKPDLSVI NRYGFNSIGH 180
  181 DAILAKIQKR VRKYIAKTSP QLLKQFDANP ASCTDPAVLG VPRSLIPNKF LGINLGKNKN 240
  241 GNEIEDYVEG VRTFGNFADI LVINVSSPNT PGLRNLQKKS ALSTLLTAVV SERNKLNSPH 300
  301 PPVLVKIAPD LNEEELTDIA DVLKKCKIDG VIVGNTTVQR PKTLKSTSHV EETGGLSGPP 360
  361 LKPIALNTLR TLRKHLSSDI PIIGCGGISS GKDAIEYARA GATMVQVYTA LGYDGPVIAH 420
  421 KIKQEILAEL KGKRWVDIIG KEE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..443] PSI-BLAST 63.09691 Rat dihydroorotate dehydrogenase (DHOD)in complex with atovaquone

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity
    		•  2.7385769437489 bayes_pls_golite062009
  • dihydroorotate dehydrogenase activity
    		•  2.73800716363956 bayes_pls_golite062009
  • dihydroorotate oxidase activity
    		•  2.35584458985229 bayes_pls_golite062009
  • catalytic activity
    		•  1.94749091175302 bayes_pls_golite062009
  • dihydropyrimidine dehydrogenase (NADP+) activity
    		•  1.76080169529176 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
    		•  0.962937319088834 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors
    		•  0.876786102965635 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.126127705865716 bayes_pls_golite062009
  • binding
    		•  0.100344139383616 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.55

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle