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Protein Overview: ade10

General Information:
Name(s) found: ade10 / SPCPB16A4.03c [Sanger Pombe]
Description(s) found:
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  • gi|3688571|emb|CAA76207.1| IMP cyclohydrolase; phosphoribosylaminoimidazolecarboxamide formyltransferase [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19075527|ref|NP_588027.1| IMP cyclohydrolase [Schizosaccharomyces pombe] [NCBI NR]
  • gi|15214204|sp|O74928.1|PUR9_SCHPO RecName: Full=Bifunctional purine biosynthesis protein ade10; Includes: RecName: Full=Phosphoribosylaminoimidazolecarboxamide formyltransferase; AltName: Full=5-aminoimidazole-4-carboxamide ribonucleotide formyltransfera [NCBI NR]
  • gi|14268499|emb|CAC39322.1| IMP cyclohydrolase/phosphoribosylaminoimidazolecarboxamideformy ltransferase [Schizosaccharomyces pombe] [NCBI NR]
  • IMP cyclohydrolase [Sanger Pombe]
  • Bifunctional purine biosynthesis protein ade10 OS=Schizosaccharomyces pombe GN=ade10 PE=2 SV=1 [Swiss-Prot]
  • 5-PHOSPHORIBOSYL-4-CARBOXAMINDE 5-AMINOIMIDAZOLE (AICAR) TRANSFORMYLASE; INOSINEMONOPHOSPHATE (IMP) CYCLOHYDROLASE (ATIC); PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXAMIDE FORMYLTRANSFERASE; SIMILAR TO S. CEREVISIAE ADE16 AND ADE17: O74928;P78892; [pompepVF.fasta]
  • PUTATIVE 5-AMINOIMIDAZOLE-4-CARBOXAMIDE RIBONUCLEOTIDE (AICAR) TRANSFORMYLASE/IMP CYCLOHYDROLASE; PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXAMIDE FORMYLTRANSFERASE: O74928;P78892; [pompepV13]
  • Bifunctional purine biosynthesis protein ade10 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (AICAR transformylase); IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP synthetase) (ATIC)] [pompep4896]
  • |ade10||IMP cyclohydrolase [pompepnew.fasta]
  • |ade10||IMP cyclohydrolase|Schizosaccharomyces pombe|chr 3|||Manual [pombe041504.fasta]
  • putative 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase/IMP cyclohydrolase [Schizosaccharomyces pombe]gi|3688571|emb|CAA76207.1| IMP cyclohydrolase; phosphoribosylaminoimidazolecarboxamide formyltransferase [Schizosaccharomyces pomb [nrdb_11152004_Chlamydomonas]
  • (O74928) Bifunctional purine biosynthesis protein ade10 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (AICAR transformylase); IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP synthetase) (ATIC)] [pompep4896_normal_reversed]
  • |ade10||IMPcyclohydrolase/phosphoribosylaminoimidazolecarboxamideformyltransferase|Schizosaccharomyces pombe|chr 3|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • SPCPB16A4.03c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPCPB16A4.03c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • Bifunctional purine biosynthesis protein ade10 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transformylase); IMP cyclohydrolase (Inosinicase) (IMP synthetase) (ATIC)] [nr-271106-contam.fasta]
  • IMP cyclohydrolase; phosphoribosylaminoimidazolecarboxamide formyltransferase [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • Bifunctional purine biosynthesis protein ade10 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ade10 PE=2 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 585 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDALink to PubMed article]
    Biological Process: IMP biosynthetic process [IMPLink to PubMed article]
    Molecular Function: IMP cyclohydrolase activity [IMPLink to PubMed article]
    phosphoribosylaminoimidazolecarboxamide formyltransferase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYALLSVYDK TGLLELAKAL TSKGVKLLGS GGTAKMIRES GMEVADVSSI TNAPEILGGR  60
   61 VKTLHPAVHG GILARDIPSD EKDLVEQSIE KIDIVVCNLY PFRETIAKPN VTIPEAVEEI 120
  121 DIGGVTLLRA AAKNHARVTI LSDPADYATF TDKFLSDKLT QDDRNTYALK AFASTASYDA 180
  181 AITDYFRKQY AAGVDQLTLR YGANPHQSPA QAFMEQGPLP FKVLCGSPGY INLMDALNSW 240
  241 PLVKELRENI GIPAAASFKH VSPAGAAVGL PLSDVEKKVY FVSDITEFTP LACAYARARG 300
  301 ADRMSSFGDF IALSDTVDVC TARIISREVS DGVIAPGYEP EALELLKKKK GGKYCVLQMD 360
  361 PKYVPAEIET RQVYGISLQQ HRNHAKIDFS LFEKVVSKNK DLPKSALIDL VIATTALKYT 420
  421 QSNSVCYAKN GMVVGLGAGQ QSRIHCNRLA GDKADNWWLR HHPKVLGMQF KKSAKRPEKS 480
  481 NAIDLYVLDA VPAEGSEREQ WESAFETIPE PLTKKEREEF LATCKDVVCA SDAFFPFPDN 540
  541 IYRLAQSGVK YVAAPGGSVM DQAVRDTANE FNMVFSEIPL RLFHH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..585] PSI-BLAST 1000.0 Crystal Structure of Human ATIC in complex with folate-based inhibitor BW1540U88UD

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • IMP cyclohydrolase activity
    		•  2.44338227123463 bayes_pls_golite062009
  • phosphoribosylaminoimidazolecarboxamide formyltransferase activity
    		•  2.17104645465987 bayes_pls_golite062009
  • formate dehydrogenase activity
    		•  2.1190774640451 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
    		•  1.79965948308471 bayes_pls_golite062009
  • catalytic activity
    		•  1.70756445127105 bayes_pls_golite062009
  • hydroxymethyl-, formyl- and related transferase activity
    		•  1.51378035087272 bayes_pls_golite062009
  • binding
    		•  1.21541060770936 bayes_pls_golite062009
  • glycine hydroxymethyltransferase activity
    		•  1.19388272840449 bayes_pls_golite062009
  • deaminase activity
    		•  1.16510523659661 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  1.03324558866637 bayes_pls_golite062009
  • cytidine deaminase activity
    		•  0.870445440530128 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.738911503392967 bayes_pls_golite062009
  • carbon-oxygen lyase activity, acting on phosphates
    		•  0.344740566585736 bayes_pls_golite062009
  • electron carrier activity
    		•  0.178707818321223 bayes_pls_golite062009
  • protein binding
    		•  0.072557222523031 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle