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Protein Overview: met9

General Information:
Name(s) found: met9 / SPAC56F8.10 [Sanger Pombe]
Description(s) found:
Found 21 descriptions.
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  • methylenetetrahydrofolate reductase Met9 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 603 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    mitochondrion [ISSLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: methionine biosynthetic process [IDALink to PubMed article]
    Molecular Function: methylenetetrahydrofolate reductase (NADPH) activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKISDKLLHP DWKEKVTYSY EFFPPKTSTG VQNLYNRIDR MKTWGRPMFV DVTWGAGGTS  60
   61 SELTPGIVNV IQTDFEVDTC MHLTCTNMST EMIDAALKRA HETGCRNILA LRGDPVKDTD 120
  121 WTEGESGFRY ASDLVRYIRT HYNDEFCIGV AGYPEGYSPD DDIDESIKHL KLKVDEGADF 180
  181 IVTQMFYDVD NFIAWVDKVR AAGINIPIFP GIMPIQAWDS FIRRAKWSGV KIPQHFMDTL 240
  241 VPVKDDDEGV RERGVELIVE MCRKLIASGI TRLHFYTMNL EKAVKMIIER LGLLDENLAP 300
  301 IVDTNNVELT NASSQDRRIN EGVRPIFWRT RNESYVSRTD QWDELPHGRW GDSRSPAFGE 360
  361 FDAIRYGLRM SPKEITTSWG SPKSYSEIGD LFARYCEKKI SSLPWSDLPI SDEADLIRDQ 420
  421 LLSMNRNAFL TINSQPALNG EKSSHPVFGW GPPNGYVFQK PYVEFFVHPS LLNELKETVK 480
  481 KLNSVSYFVT NKNGDLDTNS QYEIPNAVTW GVFPNREIIQ PTIVESTSFL AWKDEAYSLG 540
  541 MEWANAYSPD SISRKLLVSM MKEWFLCVIV DNDFQNGQSL FDVFNKMRSL KDIHPELYYA 600
  601 NAS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..293] PSI-BLAST 104.0 5,10-Methylenetetrahydrofolate Reductase from Thermus thermophilus HB8
    2 View Details [294..452] deduced N/A No confident structure predictions are available.
    3 View Details [453..603] MSA 2.026951 View MSA. Confident ab initio structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • methylenetetrahydrofolate reductase (NADPH) activity
    		•  3.97406471031265 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors
    		•  3.43788898294589 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.26500423104107 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
    		•  2.35093189018748 bayes_pls_golite062009
  • catalytic activity
    		•  2.15527229494088 bayes_pls_golite062009
  • 1-pyrroline-5-carboxylate dehydrogenase activity
    		•  2.11575302268542 bayes_pls_golite062009
  • binding
    		•  1.55766253746824 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.413628997019645 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.385543917258092 bayes_pls_golite062009
  • protein binding
    		•  0.229798056306674 bayes_pls_golite062009
  • DNA binding
    		•  0.214617895050106 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle