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Protein Overview: hmg1

General Information:
Name(s) found: hmg1 / SPCC162.09c [Sanger Pombe]
Description(s) found:
Found 18 descriptions.
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  • 3-hydroxy-3-methylglutaryl-CoA reductase [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 1053 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [IDALink to PubMed article]
    nuclear membrane [ISSLink to PubMed article]
    nuclear membrane-endoplasmic reticulum network [IDALink to PubMed article]
    integral to membrane [IEA]
    endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: farnesyl diphosphate biosynthetic process, mevalonate pathway [ISSLink to PubMed article]
    cellular cell wall organization [IMPLink to PubMed article]
    ergosterol biosynthetic process [IMPLink to PubMed article]
    coenzyme A metabolic process [IEA]
    Molecular Function: NADP or NADPH binding [IEA]
    protein binding [IPI]
    hydroxymethylglutaryl-CoA reductase (NADPH) activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIYKLAARYP IQVIAIVGIL VSMAYFSFLE ALTQEDFPVL IRALKRFGIL DGFPNTRLPN  60
   61 EMILKLSSVQ GEDASVWEQI PAAELGGEGF VDFDITQWYY PANAKVDVAQ LVEPYRNDCI 120
  121 FHDASGACHF FFKEVGNWTV SSIALPSNLA NPPIDYFLDS SSTVIQRILP AIREHGISWS 180
  181 WLLQLIARTW MNTLKIASQA SKTELLIVGT AYACMLISIV SLYLKMRRLG SKFWLFFSVL 240
  241 LSTLFSVQFA MTLVRASGVR ISLVSLIESL PFLINVVALD KAAELTRQVI TRCSVSDSHS 300
  301 PMHEDIAKAC RNAAPPILRH FSFGIVVLAI FSYCNFGIKQ FFLFAAVMIY DLLLLFSFFV 360
  361 AILTLKLEMR RYNAKDDVRK VLIEEGLSES TARHVADGND SSATTSAGSR YFKVRYGTKI 420
  421 ILFIFIAFNL FELCSIPFKH YAATSAAAAR LIPLVRSQYP DFKSQRLLDD GVFDDVLSAI 480
  481 SSMSNIESPS VRLLPAVFYG AELSSTSFLS TIHSFINNWS HYISASFLSK WIVCALSLSI 540
  541 AVNVFLLNAA RLNSIKEEPE KKVVEKVVEV VKYIPSSNSS SIDDIQKDEI AQESVVRSLE 600
  601 ECITLYNNGQ ISTLNDEEVV QLTLAKKIPL YALERVLKDV TRAVVIRRTV VSRSSRTKTL 660
  661 ESSNCPVYHY DYSRVLNACC ENVIGYMPLP LGVAGPLIID GKPFYIPMAT TEGALVASTM 720
  721 RGCKAINAGG GAVTVLTRDQ MSRGPCVAFP NLTRAGRAKI WLDSPEGQEV MKKAFNSTSR 780
  781 FARLQHIKTA LAGTRLFIRF CTSTGDAMGM NMISKGVEHA LVVMSNDAGF DDMQVISVSG 840
  841 NYCTDKKPAA INWIDGRGKS VIAEAIIPGD AVKSVLKTTV EDLVKLNVDK NLIGSAMAGS 900
  901 VGGFNAHAAN IVTAVYLATG QDPAQNVESS NCITLMDNVD GNLQLSVSMP SIEVGTIGGG 960
  961 TVLEPQGAML DLLGVRGAHM TSPGDNSRQL ARVVAAAVMA GELSLCSALA SGHLVKSHIG1020
 1021 LNRSALNTPA MDSSAKKPAT DALKSVNSRV PGR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..528] PSI-BLAST 64.154902 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains; Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains; Multidrug efflux transporter AcrB transmembrane domain
    2 View Details [529..1053] PSI-BLAST 1000.0 NAD-binding domain of HMG-CoA reductase; Substrate-binding domain of HMG-CoA reductase


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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