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Protein Overview: hem2

General Information:
Name(s) found: hem2 / SPAC1805.06c [Sanger Pombe]
Description(s) found:
Found 18 descriptions.
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  • porphobilinogen synthase Hem2 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 329 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][ISSLink to PubMed article]
    cytoplasm [ISSLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: heme biosynthetic process [ISSLink to PubMed article]
    Molecular Function: porphobilinogen synthase activity [ISSLink to PubMed article]
    zinc ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPVDISSLLH AGYSNPLLRE WQGVRPITKS SLMYPIFISE IDDAKEAIDS MPNQFRWGVN  60
   61 RLEEFLGPLV KKGLRSVILF GVIESKKDYC GSMADSENGP VIKAVKEIRH LFPELVVACD 120
  121 VCLCEYTDHG HCGLLYEDGT INNAKSVERI AEVSGNYALA GAQIISPSDC MDGRVKAIKQ 180
  181 KLVELELSHK VCVISYSAKF ASGFFGPFRA AANGAPKFGD RSCYQLPCNA RGLAKRAILR 240
  241 DVREGADGIM VKPGTPYLDI LAMASKLADD LPIATYQVSG EFAIIHAAAA AGVFELKRHV 300
  301 METMDGFMRA GANIVLTYFT PELLEWLEY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..329] PSI-BLAST 135.0 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • catalytic activity
    		•  2.67031204377352 bayes_pls_golite062009
  • porphobilinogen synthase activity
    		•  2.60788870678525 bayes_pls_golite062009
  • fructose-bisphosphate aldolase activity
    		•  0.877814788710295 bayes_pls_golite062009
  • binding
    		•  0.584966797881465 bayes_pls_golite062009
  • carbon-carbon lyase activity
    		•  0.55793298895297 bayes_pls_golite062009
  • transferase activity, transferring aldehyde or ketonic groups
    		•  0.487442544994915 bayes_pls_golite062009
  • transaldolase activity
    		•  0.184100272651834 bayes_pls_golite062009
  • transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
    		•  0.132814423759102 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.91

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle