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Protein Overview: slgA-PD

General Information:
Name(s) found: slgA-PD / FBpp0076903 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene sluggish A is referred to in FlyBase by the symbol Dmel\slgA (CG1417, FBgn0003423). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:21245368..21256188. It has the cytological map location 19F6-20A1. Based on sequence similarity, it is predicted to have molecular function</span>: proline dehydrogenase activity. There is experimental evidence that it is involved in the biological process</span>: phototaxis; locomotory behavior. 12 alleles are reported. No phenotypic data is available. It has 8 annotated transcripts and 8 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 681 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [ISS][NAS]
    Biological Process: locomotory behavior [IMP]
    glutamate biosynthetic process [ISS][NAS]
    phototaxis [IMP]
    oxidation reduction [IEA]
    proline catabolic process [ISS][NAS]
    Molecular Function: proline dehydrogenase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALLRSLSAQ RTAISLVYGR NSSKSSNSVA VAACRSFHQR GSGSTSIAGE GAASESTRGV  60
   61 NGARFLHSGD RPLQASTLVQ PEVVSSETVK RSMKQESSQE KNPSPAGSPQ RDPLDVSFND 120
  121 PIAAFKSKTT GELIRAYLVY MICSSEKLVE HNMTLMKLAR NLLGQKLFVL LMKSSFYGHF 180
  181 VAGENRHTIV PALERLRSFG VKPILDYSVE EDITQEEAEK REVESSVSSA GDKKEEGSMP 240
  241 QYHVDKSFAD RRYKVSSART YFYLNEATCE RNMEIFIKCL EAVSDDDRKA PRAVATGATF 300
  301 GTGITAIKLT ALGRPQLLLQ LSEVIMRTRK YMEDMVGGQG NVLTHHKTIK DLEKYYATLG 360
  361 DNKDVKEFLN NVTSDKEGIL HLFPWSGIVD EDSQLSDTFR VPDPQTGQMR RLISQIPPKE 420
  421 EEMFRNMIRR LNTIVKAAAD LDVRIMVDAE QTYFQPAISR ITLEMMRKYN KDKAIVFNTY 480
  481 QCYLRETFRE VNTDLEQAKR QNFYFGAKLV RGAYMDQERD RAKSLGYPDP VNPTFEATTD 540
  541 MYHRTLSECL RRIKLMKDCD DDARKIGIMV ASHNEDTVRF AIQQMKEIGI SPEDKVICFG 600
  601 QLLGMCDYIT FPLGQAGYSA YKYIPYGPVE EVLPYLSRRA QENKGVLKKI KKEKRLLLSE 660
  661 IRRRLMRGQL FYKPKGNYVP I

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..85] deduced N/A No confident structure predictions are available.
    2 View Details [86..681] PSI-BLAST 123.0 N-terminal domain of bifunctional PutA protein; Proline dehydrohenase domain of bifunctional PutA protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • oxidoreductase activity, acting on the CH-NH group of donors
    		•  6.88732579226533 bayes_pls_golite062009
  • 1-pyrroline-5-carboxylate dehydrogenase activity
    		•  6.68550231605226 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
    		•  5.85251457886657 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.26500423104107 bayes_pls_golite062009
  • catalytic activity
    		•  2.15527229494088 bayes_pls_golite062009
  • methylenetetrahydrofolate reductase (NADPH) activity
    		•  1.53575450131902 bayes_pls_golite062009
  • protein binding
    		•  1.38007868564575 bayes_pls_golite062009
  • binding
    		•  1.32681091506724 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.76

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle