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Protein Overview: fliI-PA

General Information:
Name(s) found: fliI-PA / FBpp0076893 [FlyBase]
Description(s) found:
Found 26 descriptions.
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  • The gene flightless I is referred to in FlyBase by the symbol Dmel\fliI (CG1484, FBgn0000709). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:21210823..21216117. It has the cytological map location 19F5. Based on sequence similarity, it is predicted to have molecular function</span>: calcium ion binding; actin binding. There is experimental evidence that it is involved in the biological process</span>: myofibril assembly; gastrulation involving germ band extension; flight behavior. 29 alleles are reported. The phenotypes of these alleles are annotated with: Z disc; striated muscle thin filament; striated muscle thick filament; myofibril; embryonic peripheral nervous system; sarcomere; embryonic central nervous system; blastoderm embryo; indirect flight muscle; muscle cell. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1256 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: myofibril assembly [IMP]
    flight behavior [IMP]
    gastrulation involving germ band extension [IMP]
    Molecular Function: actin binding [ISS][NAS]
    calcium ion binding [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVLPFVRGV DFTKNDFSAT FPSSMRQMSR VQWLTLDRTQ LAEIPEELGH LQKLEHLSLN  60
   61 HNRLEKIFGE LTELSCLRSL DLRHNQLKNS GIPPELFHLE ELTTLDLSHN KLKEVPEGLE 120
  121 RAKNLIVLNL SNNQIESIPT PLFIHLTDLL FLDLSHNRLE TLPPQTRRLI NLKTLDLSHN 180
  181 PLELFQLRQL PSLQSLEVLK MSGTQRTLLN FPTSIDSLAN LCELDLSHNS LPKLPDCVYN 240
  241 VVTLVRLNLS DNELTELTAG VELWQRLESL NLSRNQLVAL PAALCKLPKL RRLLVNDNKL 300
  301 NFEGIPSGIG KLGALEVFSA ANNLLEMVPE GLCRCGALKQ LNLSCNRLIT LPDAIHLLEG 360
  361 LDQLDLRNNP ELVMPPKPSE ASKATSLEFY NIDFSLQTQL RLAGAAVPPS MPSSATPKDS 420
  421 TARKIRLRRG PRSEGDQDAA KVLKGMKDVA KDKDNEAGAV PEDGKPESLK PKRWDESLEK 480
  481 PQLDYSKFFE KDDGQLPGLT IWEIENFLPN KIEEVVHGKF YEGDCYIVLK TKFDDLGLLD 540
  541 WEIFFWIGNE ATLDKRACAA IHAVNLRNFL GARCRTVREE QGDESEQFLS LFETEVIYIE 600
  601 GGRTATGFYT IEEMIHITRL YLVHAYGATI HLEPVAPAIT SLDPRHAFVL DLGTHIYIWM 660
  661 GERSKNTLNS KARLMAEKIS KTERKNKCEI QLERQGEESA EFWQGLGMTS EEADAAEPPK 720
  721 EHVPEDYQPV QPRLYQVQLG MGYLELPQVE LPEQKLCHTL LNSKHVYILD CYTDLFVWFG 780
  781 KKSTRLVRAA AVKLSRELFN MMDRPDYALV MRVPEGNEMQ IFRTKFAGWD EVMAVDFTRT 840
  841 AKSVAKTGAN LTQWARQQET RTDLAALFMP RQSAMPLAEA EQLEEEWNYD LEMMEAFVLE 900
  901 NKKFVRLPEE ELGRFYTGEC YVFLCRYCIP IEEPENGSED GANPAADVSK SSANNQPEDE 960
  961 IQCVVYFWQG RNAGNMGWLT FTFTLQKKFK AMFGEELEVV RIFQQQENLK FMSHFKRKFI1020
 1021 IHTGKRKDKA HTAKGKSPVE FFHLRSNGGA LTTRLIQINP DAVHLNSTFC YILHVPFETE1080
 1081 DDSQSGIVYV WIGSKACNEE AKLVQDIAEQ MFNSPWVSLQ ILNEGDEPEN FFWVALGGRK1140
 1141 PYDTDAEYMN YTRLFRCSNE RGYYTVAEKC ADFCQDDLAD DDIMILDNGE HVFLWMGPRC1200
 1201 SEVEVKLAYK SAQVYIQHMR IKQPERPRKL FLTMKNKESR RFTKCFHGWS AFKVYL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..511] PSI-BLAST 52.154902 The molecular structure of toll-like receptor 3 ligand binding domain
    2 View Details [512..1256] PSI-BLAST 1000.0 Gelsolin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • actin binding
    		•  7.52071741004022 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  6.04859625643932 bayes_pls_golite062009
  • actin filament binding
    		•  5.45532510538573 bayes_pls_golite062009
  • protein binding
    		•  2.93027234013365 bayes_pls_golite062009
  • binding
    		•  2.84811181543046 bayes_pls_golite062009
  • receptor binding
    		•  0.962009853725232 bayes_pls_golite062009
  • phosphatidylinositol-4,5-bisphosphate binding
    		•  0.817788495705601 bayes_pls_golite062009
  • phosphatidylserine binding
    		•  0.626075311511349 bayes_pls_golite062009
  • signal transducer activity
    		•  0.535442033390394 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.535442033390394 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.482954032096802 bayes_pls_golite062009
  • structural molecule activity
    		•  0.391701411061931 bayes_pls_golite062009
  • growth factor activity
    		•  0.374562808799 bayes_pls_golite062009
  • actin monomer binding
    		•  0.224304003054399 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle