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Protein Overview: car-PA, car-PB

General Information:
Name(s) found: car-PA / FBpp0074497 [FlyBase]
car-PB / FBpp0074496 [FlyBase]
Description(s) found:
Found 40 descriptions.
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  • The gene carnation is referred to in FlyBase by the symbol Dmel\car (CG12230, FBgn0000257). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:19460052..19463434. It has the cytological map location 18D1. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: eye pigment granule organization; endosome to lysosome transport; regulation of protein ubiquitination; compound eye pigmentation; autophagic vacuole fusion; protein targeting to lysosome; determination of adult lifespan; endosome organization; ommochrome biosynthetic process. 14 alleles are reported. The phenotypes of these alleles are annotated with: Malpighian tubule; eye; late endosome; larval brain; pigment cell. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene carnation is referred to in FlyBase by the symbol Dmel\car (CG12230, FBgn0000257). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:19460052..19463434. It has the cytological map location 18D1. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: eye pigment granule organization; endosome to lysosome transport; regulation of protein ubiquitination; compound eye pigmentation; autophagic vacuole fusion; protein targeting to lysosome; determination of adult lifespan; endosome organization; ommochrome biosynthetic process. 14 alleles are reported. The phenotypes of these alleles are annotated with: Malpighian tubule; eye; late endosome; larval brain; pigment cell. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 617 amino acids

    Gene Ontology:
    Cellular Component: membrane [TAS]
    cytosol [TAS]
    lysosome [IDA]
    Biological Process: lysosome organization [NAS]
    endosome organization [IMP]
    intracellular transport [TAS]
    determination of adult lifespan [IMP]
    endosome to lysosome transport [IMP][TAS]
    eye pigment granule organization [IMP]
    protein targeting to lysosome [IMP]
    autophagic vacuole fusion [IMP]
    vesicle-mediated transport [ISS]
    ommochrome biosynthetic process [IMP]
    vesicle docking during exocytosis [IEA]
    regulation of protein ubiquitination [IMP]
    compound eye pigmentation [IMP][TAS]
    Molecular Function: protein binding [IPI]
    SNARE binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFPHLKGHGQ RVNLQLLQEA ACRELLQQLD RIEGSKVIVL DETMIGPLDL VTRPKLFADR  60
   61 GIRLLALKPE LHLPREVANV VYVMRPRVAL MEQLAAHVKA GGRAAAGRQY HILFAPRRSC 120
  121 LCVSQLEVSG VLGSFGNIEE LAWNYLPLDV DLVSMEMPNA FRDVSVDGDT SSLYQAAVGL 180
  181 VQLQRLYGRI PKIYGKGEFA HRVWEHAKQL GRDERTLYNG DKGVVDQLIL LDRSIDLLSP 240
  241 LATQLTYEGL IDEFYGIRQN KLTLPAENFP SDGALPGGGG SGPRVEESQS LLGDTEKKTI 300
  301 LLHSGEQLYA ELRNKHFNEV TKLLARKARE IHVQMHATSQ DKSVQEIKSF VENLLPQLMA 360
  361 QKKATSEHTA IAGLLHEQVN AVRFADDLAA EQEFMVCADI DKPSAYIEDL IACRVELNRV 420
  421 LRLICMQCHA ASGFKEKLLN HYKRELVHVY GLEVLLTISN LEKSGLLHLQ TESRAYSVLR 480
  481 KTLHLTVDDN VEIEPKDISY VHSFYAPLTA RIVEHSLKPL GWQTLKSQIN NLPGPTFEDF 540
  541 QAQLVGIGGR HTVTTVSEGS LLNVPRVVLV CFVGGCTFAE IAALRFLAAQ EDNNVEFLIA 600
  601 TTKVVNKHSF LDSLMSS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..617] PSI-BLAST 137.0 Neuronal Sec1, NSec1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • SNARE binding
    		•  3.42828022195984 bayes_pls_golite062009
  • binding
    		•  2.7837022903231 bayes_pls_golite062009
  • syntaxin binding
    		•  2.11416428645287 bayes_pls_golite062009
  • protein binding
    		•  1.7224010512877 bayes_pls_golite062009
  • syntaxin-1 binding
    		•  0.269372794919901 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.85

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle