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Protein Overview: RhoGAP18B-PB, Rh...

General Information:
Name(s) found: FBpp0308368 [FlyBase]
RhoGAP18B-PF / FBpp0288900 [FlyBase]
RhoGAP18B-PB / FBpp0288897 [FlyBase]
Description(s) found:
Found 39 descriptions.
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  • type=protein; loc=X:complement(19037618..19037801,19038038..19038529,19038597..19038624,19040001..19040175,19058184..19058711); ID=FBpp0308368; name=RhoGAP18B-PH; parent=FBgn0261461,FBtr0339261; dbxref=FlyBase:FBpp0308368,FlyBase_Annotation_IDs:CG42274-PH; MD5=bcffce7a9692d0a72acfa38c6400617b; length=468; release=r5.56; species=Dmel; [FlyBase]
  • The gene RhoGAP18B is referred to in FlyBase by the symbol Dmel\RhoGAP18B (CG42274, FBgn0261461). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:19030259..19059362. It has the cytological map location 18A3-18A4. There is experimental evidence that it has the molecular function</span>: GTPase activator activity. There is experimental evidence that it is involved in the biological process</span>: behavioral response to nicotine; behavioral response to ethanol; actin filament organization. 65 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • The gene RhoGAP18B is referred to in FlyBase by the symbol Dmel\RhoGAP18B (CG42274, FBgn0261461). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:19030259..19059362. It has the cytological map location 18A3-18A4. There is experimental evidence that it has the molecular function</span>: GTPase activator activity. There is experimental evidence that it is involved in the biological process</span>: behavioral response to nicotine; behavioral response to ethanol; actin filament organization. 65 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 468 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEA]
    Biological Process: behavioral response to nicotine [IMP]
    signal transduction [IEA]
    actin filament organization [IMP]
    behavioral response to ethanol [IMP]
    Molecular Function: GTPase activator activity [IDA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGDTENKRG YRTIFRSISQ VFYANAKNSS NTNSSSSNNN NNIINYNNNT IENNNEGIGQ  60
   61 LTVTLTSITP PTATWTSTSP TISTCTTASA SAGSSTASLS PLASRSARSA ENISCSECGN 120
  121 PDPYHGQDME LAKGQALTPE VPAVPVPAAS ADQNQKLRAS SMLDLTSNHR HQNGLRIVPV 180
  181 TDILRAQQIQ EDNEVQQTQQ STILQRYKSV SIGNLLDLPG EDDKKSIKNR MRMKFAVNSN 240
  241 VFRINRSPKS EKKSRSRRGQ VNSLYLDEQK YPLFAAPLSA LELNMTDHPN VPRFVVDVCA 300
  301 YIEQPECIEQ DGLYRASGNK VLVDELRKKL THVYDPRWLK TDDIHTLTSL HKQFFRELTS 360
  361 PLITQEAYER LGRSLNDDAA IERMSLAFDD MPEPNRSTLR FLIRHLTRVA AASASNRMPS 420
  421 TNLAIVWGPC LLSANQIQLD IGRMNMLAKV LIENYDRIFH PDNERLVC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..167] PSI-BLAST 4.522879 No description for 2p0dA was found.
    2 View Details [168..468] PSI-BLAST 53.0 Crystal Structure of the Human Beta2-Chimaerin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • enzyme activator activity
    		•  0.53004209819211 bayes_pls_golite062009
  • GTPase activator activity
    		•  0.528693496432149 bayes_pls_golite062009
  • binding
    		•  0.0980674097362609 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  0.0454578418356197 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle