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Protein Overview: Fim-PA

General Information:
Name(s) found: Fim-PA / FBpp0074215 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • The gene Fimbrin is referred to in FlyBase by the symbol Dmel\Fim (CG8649, FBgn0024238). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:17179736..17196011. It has the cytological map location 15F8-16A1. Based on sequence similarity, it is predicted to have molecular function</span>: actin binding. There is experimental evidence that it is involved in the biological process</span>: female meiosis chromosome segregation. 13 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 640 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: female meiosis chromosome segregation [IMP]
    Molecular Function: actin binding [IEA][ISS][NAS]
    calcium ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATLNKFTKT LSIDEKAEIK EKFIELDANK DGFIDLHELK DALNQVGFKL AGYQVREMID  60
   61 EYKGKQLTAF QGKLNLEEFE ALCLDLKSKD VASTFKTVVS KKENLETLGG MSSISSEGTT 120
  121 HSVRLEEQLA FSDWINSNLG HDKDLQHLLP IDSEGKRLYL SIKDGILLCK IINHSCPDTI 180
  181 DERAINKKNL TVYREFENLT LALVSSQAIG CNIVNIDAHD LAKGKPHLVL GLLWQIIRIG 240
  241 LFSHITLDSC PGLAGLLFDN ERLEDLMKMS PEAILLRWVN HHLERAGISR RCTNFQSDIV 300
  301 DSEIYSHLLK QIAGNDADVN LDALRESDLQ SRAEIMLQQA AKLNCRSFLT PQDVVNGVYK 360
  361 LNLAFVANLF NNHPGLDKPE QIEGLESIEE TREEKTYRNW MNSMGVAPHV NWLYSDLADG 420
  421 LVIFQLFDVI KPGIVNWSRV HKRFSPLRKF MEKLENCNYA VDLGKQLKFS LVGIAGQDLN 480
  481 DGNATLTLAL IWQLMRAYTL SILSRLANTG NPIIEKEIVQ WVNNRLSEAG KQSQLRNFND 540
  541 PAIADGKIVI DLIDAIKEGS INYELVRTSG TQEDNLANAK YAISMARKIG ARVYALPEDI 600
  601 TEVKPKMVMT VFACMMALDY VPNMDSVDQN NHNSSANNSN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..103] PSI-BLAST 23.69897 Structure of calmodulin bound to a calcineurin peptide: a new way of making an old binding mode
    2 View Details [104..640] PSI-BLAST 118.0 CRYSTAL STRUCTURE OF THE ACTIN-CROSSLINKING CORE OF SCHIZOSACCHAROMYCES POMBE FIMBRIN

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • actin binding
    		•  7.50245214720686 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  6.48140000563569 bayes_pls_golite062009
  • actin filament binding
    		•  5.47084878097979 bayes_pls_golite062009
  • tubulin binding
    		•  4.22039137964246 bayes_pls_golite062009
  • microtubule binding
    		•  4.15537672860167 bayes_pls_golite062009
  • binding
    		•  2.8655705697659 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  2.57886434162184 bayes_pls_golite062009
  • protein binding
    		•  2.36488136094907 bayes_pls_golite062009
  • microtubule plus-end binding
    		•  2.0465241878708 bayes_pls_golite062009
  • structural constituent of muscle
    		•  1.32485442580942 bayes_pls_golite062009
  • structural molecule activity
    		•  1.00964022808548 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle