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Protein Overview: FBpp0312000, Ahc...

General Information:
Name(s) found: FBpp0312000 [FlyBase]
Ahcy13-PA / FBpp0073847 [FlyBase]
Description(s) found:
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  • gi|78099799|sp|Q27580.2|SAHH_DROME RecName: Full=Adenosylhomocysteinase; Short=AdoHcyase; AltName: Full=S-adenosyl-L-homocysteine hydrolase [NCBI NR]
  • gi|7293068|gb|AAF48453.1| adenosylhomocysteinase at 13 [Drosophila melanogaster] [NCBI NR]
  • gi|24642172|ref|NP_511164.2| adenosylhomocysteinase at 13 [Drosophila melanogaster] [NCBI NR]
  • Adenosylhomocysteinase OS=Drosophila melanogaster GN=Ahcy13 PE=2 SV=2 [Swiss-Prot]
  • type=protein; loc=X:join(15344424..15344448,15344700..15344890,15345428..15346510); ID=FBpp0312000; name=Ahcy13-PC; parent=FBgn0014455,FBtr0346181; dbxref=FlyBase:FBpp0312000,FlyBase_Annotation_IDs:CG11654-PC; MD5=8ac30a4746355ffe9f9dfceae87fd82e; length=432; release=r5.56; species=Dmel; [FlyBase]
  • The gene Adenosylhomocysteinase at 13 is referred to in FlyBase by the symbol Dmel\Ahcy13 (CG11654, FBgn0014455). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:15344295..15346683. It has the cytological map location 13C3. Based on sequence similarity, it is predicted to have molecular function</span>: adenosylhomocysteinase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: one-carbon metabolic process. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG11654-PA translation from_gene[CG11654 Ahcy13 FBgn0014455] seq_release:3 mol_weight=47367 cds_boundaries:(X:15,181,405..15,183,488[+]) aa_length:432 transcript_info:[CG11654-RA seq_release:3] gene_info:[gene symbol:Ahcy13 FBgn0014455 gene_boundaries [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VXV5) Ahcy13 protein (EC 3.3.1.1) (Adenosylhomocysteinase) (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase) [DrosMelano7227.FASTAC.txt]
  • (AE003499) Ahcy13 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG11654-PA [Drosophila melanogaster]gi|24642172|ref|NP_511164.2| CG11654-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=X:join(15344424..15344448,15344700..15344890,15345428..15346510); ID=FBpp0073847; name=Ahcy13-PA; parent=FBgn0014455,FBtr0074030; dbxref=FlyBase:FBpp0073847,FlyBase_Annotation_IDs:CG11654-PA,GB_protein:AAF48453.1,REFSEQ:NP_511164,GB_prot [fly-100309-contam.fasta]
  • Adenosylhomocysteinase at 13 CG11654-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase) [nr-271106-contam.fasta]
  • CG11654-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=X:join(15344424..15344448,15344700..15344890,15345428..15346510); ID=FBpp0073847; name=Ahcy13-PA; parent=FBgn0014455,FBtr0074030; dbxref=FlyBase:FBpp0073847,FlyBase_Annotation_IDs:CG11654-PA,GB_protein:AAF48453.1,REFSEQ:NP_511164,GB_protein:AAF48453; MD5=8ac30a4746355ffe9f9dfceae87fd82e; length=432; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=X:join(15344424..15344448,15344700..15344890,15345428..15346510); ID=FBpp0073847; name=Ahcy13-PA; parent=FBgn0014455,FBtr0074030; dbxref=FlyBase:FBpp0073847,FlyBase_Annotation_IDs:CG11654-PA,GB_protein:AAF48453.1,REFSEQ:NP_511164,GB_protein:AAF48453; MD5=8ac30a4746355ffe9f9dfceae87fd82e; length=432; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Adenosylhomocysteinase OS=Drosophila melanogaster GN=Ahcy13 PE=1 SV=2 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=X:join(15344424..15344448,15344700..15344890,15345428..15346510); ID=FBpp0073847; name=Ahcy13-PA; parent=FBgn0014455,FBtr0074030; dbxref=FlyBase:FBpp0073847,FlyBase_Annotation_IDs:CG11654-PA,GB_protein:AAF48453.1,REFSEQ:NP_511164,GB_protein:AAF48453,FlyMine:FBpp0073847,modMine:FBpp0073847; MD5=8ac30a4746355ffe9f9dfceae87fd82e; length=432; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=X:join(15450391..15450415,15450667..15450857,15451395..15452477); ID=FBpp0073847; name=Ahcy13-PA; parent=FBgn0014455,FBtr0074030; dbxref=FlyBase:FBpp0073847,FlyBase_Annotation_IDs:CG11654-PA,GB_protein:AAF48453.1,REFSEQ:NP_511164,GB_protein:AAF48453,FlyMine:FBpp0073847,modMine:FBpp0073847; MD5=8ac30a4746355ffe9f9dfceae87fd82e; length=432; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:join(15450391..15450415,15450667..15450857,15451395..15452477); ID=FBpp0312000; name=Ahcy13-PC; parent=FBgn0014455,FBtr0346181; dbxref=FlyBase:FBpp0312000,FlyBase_Annotation_IDs:CG11654-PC,GB_protein:AHN59738,REFSEQ:NP_001285268; MD5=8ac30a4746355ffe9f9dfceae87fd82e; length=432; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:join(15450391..15450415,15450667..15450857,15451395..15452477); ID=FBpp0073847; name=Ahcy13-PA; parent=FBgn0014455,FBtr0074030; dbxref=FlyBase:FBpp0073847,FlyBase_Annotation_IDs:CG11654-PA,GB_protein:AAF48453.1,REFSEQ:NP_511164,GB_protein:AAF48453,FlyMine:FBpp0073847,modMine:FBpp0073847; MD5=8ac30a4746355ffe9f9dfceae87fd82e; length=432; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • type=protein; loc=X:join(15450391..15450415,15450667..15450857,15451395..15452477); ID=FBpp0312000; name=Ahcy13-PC; parent=FBgn0014455,FBtr0346181; dbxref=FlyBase:FBpp0312000,FlyBase_Annotation_IDs:CG11654-PC,GB_protein:AHN59738,REFSEQ:NP_001285268; MD5=8ac30a4746355ffe9f9dfceae87fd82e; length=432; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of Q27580, Adenosylhomocysteinase OS=Drosophila melanogaster GN=Ahcy13 PE=3 SV=1 [DROME.fasta.20160308]
  • FBpp0073847 type=protein; loc=X:join(15450391..15450415,15450667..15450857,15451395..15452477); ID=FBpp0073847; name=Ahcy13-PA; parent=FBgn0014455,FBtr0074030; dbxref=FlyBase:FBpp0073847,FlyBase_Annotation_IDs:CG11654-PA,GB_protein:AAF48453.1,REFSEQ:NP_511164,GB_protein:AAF48453,FlyMine:FBpp0073847,modMine:FBpp0073847; MD5=8ac30a4746355ffe9f9dfceae87fd82e; length=432; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • FBpp0312000 type=protein; loc=X:join(15450391..15450415,15450667..15450857,15451395..15452477); ID=FBpp0312000; name=Ahcy13-PC; parent=FBgn0014455,FBtr0346181; dbxref=FlyBase:FBpp0312000,FlyBase_Annotation_IDs:CG11654-PC,GB_protein:AHN59738,REFSEQ:NP_001285268; MD5=8ac30a4746355ffe9f9dfceae87fd82e; length=432; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=X:join(15450391..15450415,15450667..15450857,15451395..15452477); ID=FBpp0073847; name=Ahcy-PA; parent=FBgn0014455,FBtr0074030; dbxref=FlyBase:FBpp0073847,FlyBase_Annotation_IDs:CG11654-PA,GB_protein:AAF48453.1,REFSEQ:NP_511164,GB_protein:AAF48453,UniProt/Swiss-Prot:Q27580,FlyMine:FBpp0073847,modMine:FBpp0073847; MD5=8ac30a4746355ffe9f9dfceae87fd82e; length=432; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
  • type=protein; loc=X:join(15450391..15450415,15450667..15450857,15451395..15452477); ID=FBpp0312000; name=Ahcy-PC; parent=FBgn0014455,FBtr0346181; dbxref=FlyBase:FBpp0312000,FlyBase_Annotation_IDs:CG11654-PC,GB_protein:AHN59738,REFSEQ:NP_001285268,UniProt/Swiss-Prot:Q27580; MD5=8ac30a4746355ffe9f9dfceae87fd82e; length=432; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 432 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: one-carbon metabolic process [IEA]
    Molecular Function: binding [IEA]
    adenosylhomocysteinase activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKPSYKVAD ISLAEWGRKA IIIAENEMPG LMACRKKYGP SKPLKGARIT GCLHMTVQTA  60
   61 VLIETLVELG AQVQWSSCNI FSTQDNAAAA IAATGVPVYA WKGETDEEYM WCIEQTLVFP 120
  121 DGQPLNMILD DGGDLTNLVH EKFPQYLKNI KGLSEETTTG VHNLYKMFKE GRLGVPAINV 180
  181 NDSVTKSKFD NLYGCRESLI DGIKRATDVM IAGKVCCVAG YGDVGKGCAQ ALKGFGGRVI 240
  241 VTEVDPINAL QAAMEGYEVT TMEEASKEAS IFVTTTGCRD IITSVHLQQM PDDAIVCNIG 300
  301 HFDIEIDVDW LNANAKEKVN VKPQVDRYTM QSGKHIILLA EGRLVNLGCA HGHPSFVMSN 360
  361 SFTNQVLAQI ELWTKSDKYA VGVHVLPKIL DEEVASLHLE KLGVKLTKLT EKQATYLGVS 420
  421 QTGPFKPDHY RY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..432] PSI-BLAST 144.0 S-adenosylhomocystein hydrolase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • adenosylhomocysteinase activity
    		•  4.75102111339352 bayes_pls_golite062009
  • trialkylsulfonium hydrolase activity
    		•  4.75102111339352 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.9367410227151 bayes_pls_golite062009
  • binding
    		•  0.784517759335365 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  0.418775403210681 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  0.32207755075663 bayes_pls_golite062009
  • DNA binding
    		•  0.158019531459925 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.0191997392158629 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.012678711735872 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle