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Protein Overview: rab3-GEF-PA

General Information:
Name(s) found: rab3-GEF-PA / FBpp0073810 [FlyBase]
Description(s) found:
Found 14 descriptions.
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  • The gene rab3-GEF is referred to in FlyBase by the symbol Dmel\rab3-GEF (CG5627, FBgn0030613). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:14987286..15007795. It has the cytological map location 13A11-13A12. Based on sequence similarity, it is predicted to have molecular function</span>: Rab guanyl-nucleotide exchange factor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: activation of MAPK activity; regulation of apoptosis; regulation of cell cycle. 9 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2075 amino acids

    Gene Ontology:
    Cellular Component: synaptic vesicle [NAS]
    integral to membrane [ISS]
    Biological Process: activation of MAPK activity [ISS]
    vesicle-mediated transport [NAS]
    regulation of apoptosis [ISS]
    regulation of cell cycle [ISS]
    neurotransmitter secretion [NAS]
    Molecular Function: protein binding [IEA]
    Rab guanyl-nucleotide exchange factor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDQQKASLC PRLVDYMAIV GAHTTPPMPK GLQGLKAPPV QVPDLLRRYP PSDHADFPLP  60
   61 LDMVYFCQPE GCTSVGPRRT GSAIRDMTSF VFALTDKDSG KTRYGICVNF YRPIERPSSA 120
  121 AGSAGAGNDR PGNGGPGGHG GGAGGGAGGG GRAPSDSDRE LTSRRDSDQQ RLHSHHSHHQ 180
  181 PHHPSASPAV PKLGLMAPSA DSESGGSHSP SPRASRKRTK LRNQSLTSLC IISHHPFFTT 240
  241 FRECLFILKK LIDACNESSS PKRVGASQKI NRDNVWTVLT GHVSDATPSI VLHDVREIET 300
  301 WILRLLSTPV PVPGSTRVEV EVLSPTVHEP LLFALPDHTR FSLVDFPLHL PLELLGVETC 360
  361 LKVWTLIMQE NKVLFQSRDY NALSMSVMAF VTMLYPLEYM FPVIPLLPTC LSCAEQLLLA 420
  421 PTPFVIGVPA SFLVYKKNFR LPDDIWVVDL DSTKLTPPTG GYEEIPPLPE PEGTILKNHL 480
  481 KQVSPKALSL NSLRLPLQTP PHSAQASQRN SMSAQGTISS RQPSPMNSPA LNPFVYGTDV 540
  541 DSVDVATRVA MVRFFNAQNT LANFAEHTRT LRLYPRPVVA FQINSFLRSR PRASQFLNQF 600
  601 ARTQAVEFLA EWSLTPTNVA FLRVQTGVMD PMQVGDKPKW FAHALTPIRF SVWDDGSSLN 660
  661 GALRSLKQLE CQPTDESGSD SEGADSSSSS YSSLSDFVSE MASSDLSPSL HDVFGSYNRP 720
  721 HVVPQTLSSN LDPALVYHPP SKLQYPEGIA DAVASKEEED EERADSPVSS SSSRSDLSSP 780
  781 SFNRDSEFDF QPKGGQTLGS TTVGSGAAAP SFELATPLAM RLEATIKMAS IEQESDTVST 840
  841 ATGKTIAAGS KLQRHPSDSE SRPEKKIPPP LTPPVKQPGV SNILARTGSS GSSSSSPGRQ 900
  901 SSQSSLFENF ASHAKELVRE TTRQSSQEGL LAHVDKHALD EDLDDKMRHT FEKFTLHAKK 960
  961 AAGEASKQAL EVSKQAAGVS KNTLEDLTYV GKSTLGDLTK TAKEAATKKG IIKIEEHSAG1020
 1021 GAGPPPKSPG SQLATHKQVQ QSGGQGGGNN FFSAIGTDFN GLASSTSTMF SGMFGKKSQQ1080
 1081 KQVPVQQKQP NVSAGKAKSG INFDPFPGRK GLVERTPLIK HSGPRQTQEE LTRQQNQERS1140
 1141 HSNAENQTFL KDVTNQVLAG EGVGWLKLNR FKKLMEDESY RTLVLSKLNK TLDKKIAPDD1200
 1201 HIDDVCVTKP VWKGMLKCIQ AIAGGLDVTF ANFGLGGMAS VFQLMEVAHT HYWSKEINEG1260
 1261 SDMSSSLLSS HAASPMGSRE NLRSPSSPNG SHSALGSEWA SPQESRKSST QLAHGGPGGS1320
 1321 HSGAPINRRL SSADSQDGQS TTEMFKDMLS QKRSALKNML TSFDSDAAGS TGALSVVSLG1380
 1381 VRLPSSCRST VSDTEYENTT TSKDSKKSSG NLWSGKSTLS AGFRYTGGHL INTSSSPSPD1440
 1441 SPRVYLFEGL LGKDRLNLWN QMQFWEDAFL DAVSQERDMI GMDQGPIEMM ERYKSLSESE1500
 1501 RKRLEHDEDR LLSTMLYNLT AILVMLNVAK DEIRRKIRRL LGKSHIGLVY SQEVHNVVDQ1560
 1561 INNLNGNDID LKPLGSRLLH RQSFTVHQGT DVNGPLRFME VRDDGLVLRS VDGTIVERWW1620
 1621 YERLVNMTYS PKTKLLCLWR RNGGQTQLHK YYTRKCKELY NCIKEAMERG GTPTNVPELG1680
 1681 GEFPVQDMNT GEGGLLQVCL EGVGLLFSNS KFFVRLDHIR KCFTQKGGIF VLEEYNPKTR1740
 1741 NLIQRKYQSS MSDQICYSVL CVFSYVAAGQ DQKKNPVVIT PQIQDIHAQQ KQKHQQQQQH1800
 1801 QQPQQQQQPH QTTTQQNQPT AVASAVPTTT APAGQVNPNR MTAKSQAGSI SIRHTVPMQK1860
 1861 PTITMSTVQP QARMPAQVAT ASVPVTVPVP PTPAPPTSNP AKLPQLPPRV PSQPSTESLA1920
 1921 SISSPPPKLR TPMSAPPGPP PAIPPRTGAI SRSGSVPAAR SFVRQASANS TPPQYTPQPP1980
 1981 PPFVIPKRHS GLARASTLSS STSPSMSSSS ASNHPGHSQS QQRASHGSVA AVLQSMPEAE2040
 2041 PGYGSGSGSI SGSSSGSGSA SGSIASASPQ AHRKH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..182] Pfam 50.958607 No description for PF03456.9 was found. No confident structure predictions are available.
    2 View Details [183..263] deduced N/A No confident structure predictions are available.
    3 View Details [264..459] MSA 1.107962 View MSA. No confident structure predictions are available.
    4 View Details [460..526] deduced N/A No confident structure predictions are available.
    5 View Details [527..636] Pfam 26.142668 No description for PF03455.10 was found. No confident structure predictions are available.
    6 View Details [637..742] deduced N/A No confident structure predictions are available.
    7 View Details [743..945] deduced N/A No confident structure predictions are available.
    8 View Details [946..1040] deduced N/A No confident structure predictions are available.
    9 View Details [1041..1258] deduced N/A No confident structure predictions are available.
    10 View Details [1259..1357] deduced N/A No confident structure predictions are available.
    11 View Details [1358..1426] deduced N/A No confident structure predictions are available.
    12 View Details [1427..1671] deduced N/A No confident structure predictions are available.
    13 View Details [1672..2075] PSI-BLAST 8.69897 No description for 1y0fA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.82

    Source: Reynolds et al. (2008)

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