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Protein Overview: Usp7-PB

General Information:
Name(s) found: Usp7-PB / FBpp0073474 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene ubiquitin-specific protease 7 is referred to in FlyBase by the symbol Dmel\Usp7 (CG1490, FBgn0030366). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:11916861..11923061. It has the cytological map location 11A1-11A2. Based on sequence similarity, it is predicted to have molecular function</span>: ubiquitin-specific protease activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: protein deubiquitination. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1129 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS]
    Biological Process: protein deubiquitination [ISS]
    ubiquitin-dependent protein catabolic process [IEA]
    Molecular Function: ubiquitin-specific protease activity [ISS]
    ubiquitin thiolesterase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEIETDQSIE AMDTQDTQEV EILTSDLQQT QQQRNSPPQL PKFKNLIQPQ LHAVGAVTQL  60
   61 PSENGNMPPQ QLLADSSSTS FGDGEAMGID DESKEDQFRS ETTFSFTVEN VVQLKSQRLS 120
  121 PPVYVRMLPW RIMVIPNDRA LGFFLQCNGE NDSPTWSCNA IAELRLKCHK PDAQPFTRAR 180
  181 IKHLFYSKEN DYGYSNFITW QELKDSEKSY VHNNSITLEV HVVADAPHGV LWDSKKHTGY 240
  241 VGLKNQGATC YMNSLLQTLY FTNSLRLSVY RIPTEADDSS KSVGLSLQRV FHELQFGDRP 300
  301 VGTKKLTKSF GWETLDSFMQ HDVQEFLRVL LDKLESKMKG TILEGTIPGL FEGKMSSYIK 360
  361 CKNVDYNSTR YETFYDIQLN IKDKKNIYES FQDYVAPETL EGDNKYDAGV HGLQEASKGV 420
  421 IFTSFPPVLH LHLMRFQYDP VTDSSIKYND RFEFYEHINL DRYLAESENT LADYVLHAVL 480
  481 VHSGDNHGGH YVVFINPKAD GRWFKFDDDV VSSCRKQEAI EQNYGGMDDE ISFHAKCSNA 540
  541 YMLVYIRQSE LDRVLGDITE SEISSDLVER LDLEKRIEMA RRKERGEANT YVSVHVILEE 600
  601 NFEEQHKRRL FDLEKVHPRV FRIKQNQTVD ELVDLFVRGF GVSRQRMRMW NLCTAQTQKF 660
  661 SHFDFVAEGS RTIEQISTSQ KPWVIWLQLA WTDVPGPLPP FNPKTESLLF LKYYDPRNKR 720
  721 LNYIGCTQQP HTRRLIDLVP DVNSKLGFEP DTELTIYDEY ADKKLVNLNE PIESALFIPQ 780
  781 DHLQGHILIF ERENVDAKLD LPTVGDYFLD LVYRIEIIFS DKCNPNEPDF TLELSNRYNY 840
  841 DQLANAVAER LNTDPQKLQF FMCINNYKET AGNAVPYTFK GTIKDLVSYT KQSSTKRIFY 900
  901 QRLSLSIHEL DNKKQFKCVW VSSDLKDEKE LVLYPNKNDT VKGLLEEAAK KISFAENSRR 960
  961 KLRLLKISNH KIVAVCKDDI PLDTLLKSNE SITTAQGAQK TFRIEEVPAE DMQLAENEFL1020
 1021 IPVAHFSKEL YNSFGIPFLT KARQGEPYGA LKQRIQRRLN VQDKEWENYK FCVISMGHNA1080
 1081 DVNDNTPVDL EVYRSWTSGQ LPFFGLDHIN KSRKRSSLNF SEKAIKIYN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..598] PSI-BLAST 90.69897 Crystal structure of HAUSP
    2 View Details [599..658] FFAS03 1.06 Solution structure of the C-terminal ubiquitin-like domain of mouse tubulin-specific chaperone e
    3 View Details [659..1060] FFAS03 1.16 No description for 2gfoA was found.
    4 View Details [1061..1129] FFAS03 1.09 Structure of USP14, a proteasome-associated deubiquitinating enzyme


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

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