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Protein Overview: bif-PB

General Information:
Name(s) found: bif-PB / FBpp0073371 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene bifocal is referred to in FlyBase by the symbol Dmel\bif (CG1822, FBgn0014133). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:11573028..11588774. It has the cytological map location 10D4-10D5. There is experimental evidence that it has the molecular function</span>: actin binding; actin filament binding; microtubule binding. There is experimental evidence that it is involved in the biological process</span>: female meiosis chromosome segregation; negative regulation of axon extension; axon guidance. 31 alleles are reported. The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: adult segment; nervous system; multi-cell-component structure; peripheral nervous system; external compound sense organ; organ system; adult brain; rhabdomere; protein complex; compound cell cluster organ; larval head segment. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1235 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA]
    Biological Process: negative regulation of axon extension [IMP]
    carbohydrate catabolic process [IEA]
    axon guidance [IMP]
    female meiosis chromosome segregation [IMP]
    Molecular Function: actin filament binding [IDA]
    actin binding [IDA]
    catalytic activity [IEA]
    protein phosphatase 1 binding [NAS]
    carbohydrate binding [IEA]
    microtubule binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MESQKRPSLD LHTDVPAGLA AGGSGLGAAA EMSPTSGFLP DMPQWKKDLI QRRKTNVART  60
   61 QAASITSPTD GSCGALAEAN AAPGAIADFT EPATISSTSQ KRNMIGSEEK SEKSSISNTN 120
  121 SDSTGGHHSV VAVSLSPDAA ATTNVTVTPI PKQRSSLLNT RSQEREMVRY ILSESGERDG 180
  181 ELESGEQPAG VVSNSRCGEV ETGTIGSPSS SANQNPNPNH LKTKCKPGQS VAEGKPSAKE 240
  241 TIVDNSKSCS KTKSISDKLQ SNKFIIQQQQ QQQQQQQQQQ QLSPTKVTVK PTMVAMQEMK 300
  301 KTTKQNGQHR HLAGKIGSVA GGDVDPQHPP TNPIPDSLDT GEDLSYGPGI VSKLRCRYLS 360
  361 LALRESRQQS SKQRLQRSTS LNTLLDRDDD EVEVEEPEMT NSQVRAKSTP PPILGAKPTP 420
  421 KPSSQHQRPV SLGANGAGSA VNPPSNSDQA QTGAVANGGA GSGQRSRHFK RGNEVMKRAR 480
  481 SVEALLCEKS PWNSQRISTA GAAAAAAPSP PAPKATAAAP SPVTSPTCVT IEDKIHNARE 540
  541 RLHSGTDTAP PKRLTSIIDD TERPPPDLVK QTLKMFEASA NRRPRAAHRS NGVGGVASKV 600
  601 ANYKSIIKDQ KQPSSAAATP PPTGMGFASS TPLRHVHPDI IPRQVDSPVS ALSVMMRRME 660
  661 LQEPETPERE TRDAEATPQS EALSETERND RDEGDGEVDD DNHNNNDDDH DDGDDGSDNN 720
  721 EQRDKMGAAA AGDKPKPPAE SAAGGAQRSF AASTENAHVA SGSSSSTSAS VRKLSNNNDS 780
  781 SSGPAVTKQI GVIRPLFNSQ GAGSTPLTSR EIEKNRINEM KKSTATDAGG SVSGSGTVAG 840
  841 AGSGTSPTTS LDSVINTKEA ASSETDASAS PLWTLRKLRN QSQTAGGGSG PSSSLHSTEN 900
  901 TSMVFNFSKS TKEVPDYIES DVVIYRRKRE LPKPNEPGFV LLGDLSVETS TDTDYDDYSM 960
  961 CPPSPCDVEF ENANIVIDGK SSIRQKPKES SFRVQFNDTL TSTFEYPSEA SMTIEDPPYA1020
 1021 DPFGHVSKHH QMLLAEQMHL LQHQEQLELE QMHQLGLAPE QHHHVTVDEI IELPTSTAGH1080
 1081 GHGIGLGHRS GAAGGGGTML GNLPLGSTAL GFYTPMKGTA MDNLFQLGVT RYALPESSSS1140
 1141 GSSNGSHSPG SNGSSPAGAA GSRLMFNGNG SIMGIGEGLI KEGDLAATEA GPGTADGAGA1200
 1201 SKKGSAVDED DYHLTATPGA EVVYSEGTQK TDLLY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..230] deduced N/A No confident structure predictions are available.
    2 View Details [231..410] deduced N/A No confident structure predictions are available.
    3 View Details [411..556] deduced N/A No confident structure predictions are available.
    4 View Details [557..805] MSA 2.194995 View MSA. No confident structure predictions are available.
    5 View Details [806..935] MSA 2.171987 View MSA. No confident structure predictions are available.
    6 View Details [936..1020] deduced N/A No confident structure predictions are available.
    7 View Details [1021..1159] deduced N/A No confident structure predictions are available.
    8 View Details [1160..1235] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.49

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle