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Protein Overview: CG1657-PA

General Information:
Name(s) found: CG1657-PA / FBpp0073304 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG1657 (CG1657, FBgn0030286). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:11219495..11228107. It has the cytological map location 10B3. Based on sequence similarity, it is predicted to have molecular function</span>: Rab guanyl-nucleotide exchange factor activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: regulation of small GTPase mediated signal transduction. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1712 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEA]
    Biological Process: regulation of small GTPase mediated signal transduction [IEA]
    Molecular Function: GTPase activator activity [IEA]
    Rab guanyl-nucleotide exchange factor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPPAAGNLL EIMDLARTLR QEQLFIQQEQ AAFAQLTGAF ESNAGTITKL AFVCAQQRQI  60
   61 LNELLLARTD QDPLLFCRRA SAYDSAQFVD AKQLLPYEHA LAYEDLFNYL YNTPYLLALS 120
  121 LATADRLSLL SASQLGQIIN TIATGLYGNA INTKDVELLL KLLRELIEIQ LLTSEQPRRL 180
  181 LRTNSSSFAR LYQRLVESLF SARIFLTAAL HAPLMGVLSE HEIWLDLDPH KLMQTFTPKE 240
  241 REKRFGREGD EEYQRNVARF HAETLGKLHS HVQEFVKSLQ QSWALFPSSL RWLLQTLSQQ 300
  301 LRQSLRHEEQ EIRQLLTDLV FTHFISPAIA SADLLGIIDV NVSERMRHNL NQIVKLLQRL 360
  361 ALNDEDSELV QLMELLMLGQ TGEDVVAILP QQSDFERSQL AINQRELAQL VEFFRLLTAR 420
  421 DEYDISVEER QRLQRILGRI PKQQVQQQQQ TPKDAPDSRE SPEKSKKSNK SLMSLGKAKK 480
  481 KLAKGMSFSS GSSNHNPVPV SEPLTNGQAN TSNGSGGLGA DLEHCSSHSG SNTSLSSCGA 540
  541 NMPTTNDPLD MSTSSDPVLV FSLYNAGAKS KLKPLTEEEV LKMNSIGQDG SNLLPAVVTT 600
  601 APLAPSSNND DVSSLEAMRR PQDDASIGNS DNLEAISEAA HSVASSLDLE EQQERDVHEN 660
  661 EDNLSDMVSA NVSGRGTPNI SGRDTPSSQV TDGDGAGGDL GHHHGVHARA AANPQMQKML 720
  721 LSKARSDIED KFCKFELKKF EGDENVSIIS DTWSTDVLAS DSENTLDATV SERGDRDRNF 780
  781 STPLIPSAVV LPGDNNFVVE ALARAGRVSG VHGPQLDASD QRSESNWSTD VLASDSEKLA 840
  841 EIDTDDNVSI TTKSDTTAPQ AAVLDDDDED EQTPGSSGDG EPDPDRGNGS ERSQEDSAFF 900
  901 DAVNSYEDAN LYHGASSLAR SSVRTSYHVL GGESSFQQQY KCSGADSSGR KTTPLMGTSC 960
  961 MRRQTSAESS ISNQSLNLEE PPPPMGKHHH HHREHHHRDY HHHHRERERE RERERSALKK1020
 1021 KKHQQQEKEH RDLIDFSDCS EDKEELARNR DEEQPPGLVQ QLLDMINQDE QTGAVSSSSP1080
 1081 NVEHRRISIE QRSAIIDGRR NGILAGSMRR HQSLNYENHE IMLNSMLPKT DDDKQEMLLC1140
 1141 VQTQQLQLEE RRGSAGLRPE VDGASGIAAA GGSGLKPPTK ATGAIPKSIS FDASADKDKQ1200
 1201 TYHRDGERDR ERDRERERDR ERDRERDRER DRERDHHGAG IFNKLRQGIF KNRRGASAKN1260
 1261 ASNSSNQSNP AASTSSVQAD IRSVSFDPSA GCDNFGTHYC DTSEDILAKY RRKVSSSSEA1320
 1321 TNSDSTGNGH GVGSTGSVGA AAHLHKHMNG GHIPGVVFGC VKQKLRTVLS RTDLHSGDFR1380
 1381 QTSTTSTTMA TPLQIYLQIQ LAQCISLQRL PQISHVAEAL RCLAQLERPQ HGQLLAELQR1440
 1441 DLERRQSYLQ YLMRHRQQLL LRSEQLEQLE ARLRGEARSS QRCLLQALVR MYLAWSRQQE1500
 1501 KLEQFQAEFA QLRASDERVE LTEEFVESLL QELRSSADLQ DEWQVDAARV AIERMLLEQM1560
 1561 YEQVMFPNED ADVSRDEVLS AHIGKLQRFV HPAHPALCIA QEYLGEAPWT FAQQQLCHMA1620
 1621 AYKTPREKLQ CIINCISSIM SLLRMSSGRV PAADDLLPVL IYVVIMANPP YLLSTVEYIS1680
 1681 CFLGKKLEGE DEFYWTLFGS VVKFIKTMDY LD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..83] deduced N/A No confident structure predictions are available.
    2 View Details [84..439] PSI-BLAST 64.30103 GAP related domain of neurofibromin
    3 View Details [440..656] deduced N/A No confident structure predictions are available.
    4 View Details [657..816] MSA 1.393996 View MSA. No confident structure predictions are available.
    5 View Details [817..983] MSA 3.386993 View MSA. No confident structure predictions are available.
    6 View Details [984..1206] FFAS03 1.12 Crystal structure of NimA from D. radiodurans
    7 View Details [1207..1461] deduced N/A No confident structure predictions are available.
    8 View Details [1462..1712] PSI-BLAST 87.0 Crystal Structure of the Vps9 Domain of Rabex-5

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • enzyme regulator activity
    		•  0.68732227880003 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.590837939249671 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.59070509814251 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.53004209819211 bayes_pls_golite062009
  • GTPase activator activity
    		•  0.528693496432149 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  0.10243777232979 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  0.0454578418356197 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • catalytic activity
    		•  0.106460697391863 bayes_pls_golite062009
    7 No functions predicted.
    8 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.82

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle