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View Structure Prediction Details

Protein: CG1657-PA
Organism: Drosophila melanogaster
Length: 1712 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG1657-PA.

Description E-value Query
Range
Subject
Range
RME6_DROPS - Receptor-mediated endocytosis protein 6 homolog OS=Drosophila pseudoobscura pseudoobscura GN=GA14078...
gi|125981167, gi... - gi|54642900|gb|EAL31644.1| GA14078-PA [Drosophila pseudoobscura], gi|125981167|ref|XP_001354590.1| G...
754.0 [0..1] [1712..1]

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Predicted Domain #1
Region A:
Residues: [1-83]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPPAAGNLL EIMDLARTLR QEQLFIQQEQ AAFAQLTGAF ESNAGTITKL AFVCAQQRQI  60
   61 LNELLLARTD QDPLLFCRRA SAY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [84-439]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSAQFVDAKQ LLPYEHALAY EDLFNYLYNT PYLLALSLAT ADRLSLLSAS QLGQIINTIA  60
   61 TGLYGNAINT KDVELLLKLL RELIEIQLLT SEQPRRLLRT NSSSFARLYQ RLVESLFSAR 120
  121 IFLTAALHAP LMGVLSEHEI WLDLDPHKLM QTFTPKEREK RFGREGDEEY QRNVARFHAE 180
  181 TLGKLHSHVQ EFVKSLQQSW ALFPSSLRWL LQTLSQQLRQ SLRHEEQEIR QLLTDLVFTH 240
  241 FISPAIASAD LLGIIDVNVS ERMRHNLNQI VKLLQRLALN DEDSELVQLM ELLMLGQTGE 300
  301 DVVAILPQQS DFERSQLAIN QRELAQLVEF FRLLTARDEY DISVEERQRL QRILGR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 64.30103
Match: 1nf1A
Description: GAP related domain of neurofibromin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
enzyme regulator activity 0.68732227880003 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.590837939249671 bayes_pls_golite062009
GTPase regulator activity 0.59070509814251 bayes_pls_golite062009
enzyme activator activity 0.53004209819211 bayes_pls_golite062009
GTPase activator activity 0.528693496432149 bayes_pls_golite062009
small GTPase regulator activity 0.10243777232979 bayes_pls_golite062009
Ras GTPase activator activity 0.0454578418356197 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [440-656]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPKQQVQQQQ QTPKDAPDSR ESPEKSKKSN KSLMSLGKAK KKLAKGMSFS SGSSNHNPVP  60
   61 VSEPLTNGQA NTSNGSGGLG ADLEHCSSHS GSNTSLSSCG ANMPTTNDPL DMSTSSDPVL 120
  121 VFSLYNAGAK SKLKPLTEEE VLKMNSIGQD GSNLLPAVVT TAPLAPSSNN DDVSSLEAMR 180
  181 RPQDDASIGN SDNLEAISEA AHSVASSLDL EEQQERD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [657-816]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VHENEDNLSD MVSANVSGRG TPNISGRDTP SSQVTDGDGA GGDLGHHHGV HARAAANPQM  60
   61 QKMLLSKARS DIEDKFCKFE LKKFEGDENV SIISDTWSTD VLASDSENTL DATVSERGDR 120
  121 DRNFSTPLIP SAVVLPGDNN FVVEALARAG RVSGVHGPQL 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [817-983]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DASDQRSESN WSTDVLASDS EKLAEIDTDD NVSITTKSDT TAPQAAVLDD DDEDEQTPGS  60
   61 SGDGEPDPDR GNGSERSQED SAFFDAVNSY EDANLYHGAS SLARSSVRTS YHVLGGESSF 120
  121 QQQYKCSGAD SSGRKTTPLM GTSCMRRQTS AESSISNQSL NLEEPPP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [984-1206]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PMGKHHHHHR EHHHRDYHHH HRERERERER ERSALKKKKH QQQEKEHRDL IDFSDCSEDK  60
   61 EELARNRDEE QPPGLVQQLL DMINQDEQTG AVSSSSPNVE HRRISIEQRS AIIDGRRNGI 120
  121 LAGSMRRHQS LNYENHEIML NSMLPKTDDD KQEMLLCVQT QQLQLEERRG SAGLRPEVDG 180
  181 ASGIAAAGGS GLKPPTKATG AIPKSISFDA SADKDKQTYH RDG

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.12
Match: 1w3oA
Description: Crystal structure of NimA from D. radiodurans
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 0.106460697391863 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [1207-1461]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ERDRERDRER ERDRERDRER DRERDRERDH HGAGIFNKLR QGIFKNRRGA SAKNASNSSN  60
   61 QSNPAASTSS VQADIRSVSF DPSAGCDNFG THYCDTSEDI LAKYRRKVSS SSEATNSDST 120
  121 GNGHGVGSTG SVGAAAHLHK HMNGGHIPGV VFGCVKQKLR TVLSRTDLHS GDFRQTSTTS 180
  181 TTMATPLQIY LQIQLAQCIS LQRLPQISHV AEALRCLAQL ERPQHGQLLA ELQRDLERRQ 240
  241 SYLQYLMRHR QQLLL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1462-1712]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSEQLEQLEA RLRGEARSSQ RCLLQALVRM YLAWSRQQEK LEQFQAEFAQ LRASDERVEL  60
   61 TEEFVESLLQ ELRSSADLQD EWQVDAARVA IERMLLEQMY EQVMFPNEDA DVSRDEVLSA 120
  121 HIGKLQRFVH PAHPALCIAQ EYLGEAPWTF AQQQLCHMAA YKTPREKLQC IINCISSIMS 180
  181 LLRMSSGRVP AADDLLPVLI YVVIMANPPY LLSTVEYISC FLGKKLEGED EFYWTLFGSV 240
  241 VKFIKTMDYL D

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 87.0
Match: 1txuA
Description: Crystal Structure of the Vps9 Domain of Rabex-5
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle