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Protein Overview: Trxr-1-PC

General Information:
Name(s) found: Trxr-1-PC / FBpp0071117 [FlyBase]
Description(s) found:
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  • gi|92109834|gb|ABE73241.1| IP15366p [Drosophila melanogaster] [NCBI NR]
  • gi|24640553|ref|NP_727252.1| thioredoxin reductase-1, isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|22831937|gb|AAN09228.1| thioredoxin reductase-1, isoform C [Drosophila melanogaster] [NCBI NR]
  • The gene Thioredoxin reductase-1 is referred to in FlyBase by the symbol Dmel\Trxr-1 (CG2151, FBgn0020653). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:8136517..8142072. It has the cytological map location 7D22-7E1. There is experimental evidence that it has the molecular function</span>: glutathione-disulfide reductase activity; thioredoxin-disulfide reductase activity; antioxidant activity; protein homodimerization activity. There is experimental evidence that it is involved in the biological process</span>: response to hypoxia; cellular response to DNA damage stimulus; determination of adult lifespan. 20 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • >CG2151-PC translation from_gene[CG2151 Trxr-1 FBgn0020653] seq_release:3 mol_weight=55115 cds_boundaries:(X:7,983,377..7,986,637[+]) aa_length:508 transcript_info:[CG2151-RC seq_release:3] gene_info:[gene symbol:Trxr-1 FBgn0020653 gene_boundaries:(X:7 [hmr_yeast5_DM3-1_pombe.fasta]
  • CG2151-PC, isoform C [Drosophila melanogaster]gi|24640553|ref|NP_727252.1| CG2151-PC [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=X:join(8138464..8138530,8140127..8140472,8140543..8140769,8140841..8141727); ID=FBpp0071117; name=Trxr-1-PC; parent=FBgn0020653,FBtr0071169; dbxref=FlyBase:FBpp0071117,FlyBase_Annotation_IDs:CG2151-PC,GB_protein:AAN09228.1,REFSEQ:NP_7272 [fly-100309-contam.fasta]
  • CG2151-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Thioredoxin reductase-1 CG2151-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta]
  • IP15366p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=X:join(8138464..8138530,8140127..8140472,8140543..8140769,8140841..8141727); ID=FBpp0071117; name=Trxr-1-PC; parent=FBgn0020653,FBtr0071169; dbxref=FlyBase:FBpp0071117,FlyBase_Annotation_IDs:CG2151-PC,GB_protein:AAN09228.1,REFSEQ:NP_727252,GB_protein:AAN09228; MD5=791917605868c181bcb3b4c5b5376273; length=508; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=X:join(8138464..8138530,8140127..8140472,8140543..8140769,8140841..8141727); ID=FBpp0071117; name=Trxr-1-PC; parent=FBgn0020653,FBtr0071169; dbxref=FlyBase:FBpp0071117,FlyBase_Annotation_IDs:CG2151-PC,GB_protein:AAN09228.1,REFSEQ:NP_727252,GB_protein:AAN09228; MD5=791917605868c181bcb3b4c5b5376273; length=508; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Isoform C of Thioredoxin reductase 1, mitochondrial OS=Drosophila melanogaster GN=Trxr-1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=X:join(8138464..8138530,8140127..8140472,8140543..8140769,8140841..8141727); ID=FBpp0071117; name=Trxr-1-PC; parent=FBgn0020653,FBtr0071169; dbxref=FlyBase:FBpp0071117,FlyBase_Annotation_IDs:CG2151-PC,GB_protein:AAN09228.1,REFSEQ:NP_727252,GB_protein:AAN09228,FlyMine:FBpp0071117,modMine:FBpp0071117; MD5=791917605868c181bcb3b4c5b5376273; length=508; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=X:join(8244431..8244497,8246094..8246439,8246510..8246736,8246808..8247694); ID=FBpp0071117; name=Trxr-1-PC; parent=FBgn0020653,FBtr0071169; dbxref=FlyBase:FBpp0071117,FlyBase_Annotation_IDs:CG2151-PC,GB_protein:AAN09228.1,REFSEQ:NP_727252,GB_protein:AAN09228,FlyMine:FBpp0071117,modMine:FBpp0071117; MD5=791917605868c181bcb3b4c5b5376273; length=508; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:join(8244431..8244497,8246094..8246439,8246510..8246736,8246808..8247694); ID=FBpp0071117; name=Trxr-1-PC; parent=FBgn0020653,FBtr0071169; dbxref=FlyBase:FBpp0071117,FlyBase_Annotation_IDs:CG2151-PC,GB_protein:AAN09228.1,REFSEQ:NP_727252,GB_protein:AAN09228,FlyMine:FBpp0071117,modMine:FBpp0071117; MD5=791917605868c181bcb3b4c5b5376273; length=508; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of P91938, Isoform C of Thioredoxin reductase 1, mitochondrial OS=Drosophila melanogaster GN=Trxr-1 [DROME.fasta.20160308]
  • FBpp0071117 type=protein; loc=X:join(8244431..8244497,8246094..8246439,8246510..8246736,8246808..8247694); ID=FBpp0071117; name=Trxr-1-PC; parent=FBgn0020653,FBtr0071169; dbxref=FlyBase:FBpp0071117,FlyBase_Annotation_IDs:CG2151-PC,GB_protein:AAN09228.1,REFSEQ:NP_727252,GB_protein:AAN09228,FlyMine:FBpp0071117,modMine:FBpp0071117; MD5=791917605868c181bcb3b4c5b5376273; length=508; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=X:join(8244431..8244497,8246094..8246439,8246510..8246736,8246808..8247694); ID=FBpp0071117; name=Trxr-1-PC; parent=FBgn0020653,FBtr0071169; dbxref=FlyBase:FBpp0071117,FlyBase_Annotation_IDs:CG2151-PC,GB_protein:AAN09228.1,REFSEQ:NP_727252,GB_protein:AAN09228,FlyMine:FBpp0071117,modMine:FBpp0071117; MD5=791917605868c181bcb3b4c5b5376273; length=508; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 508 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKYMICAIV VGAKKSTSSK YNGSYDYDLI VIGGGSAGLA CAKEAVLNGA RVACLDFVKP  60
   61 TPTLGTKWGV GGTCVNVGCI PKKLMHQASL LGEAVHEAAA YGWNVDEKIK PDWHKLVQSV 120
  121 QNHIKSVNWV TRVDLRDKKV EYINGLGSFV DSHTLLAKLK SGERTITAQT FVIAVGGRPR 180
  181 YPDIPGAVEY GITSDDLFSL DREPGKTLVV GAGYIGLECA GFLKGLGYEP TVMVRSIVLR 240
  241 GFDQQMAELV AASMEERGIP FLRKTVPLSV EKQDDGKLLV KYKNVETGEE AEDVYDTVLW 300
  301 AIGRKGLVDD LNLPNAGVTV QKDKIPVDSQ EATNVANIYA VGDIIYGKPE LTPVAVLAGR 360
  361 LLARRLYGGS TQRMDYKDVA TTVFTPLEYA CVGLSEEDAV KQFGADEIEV FHGYYKPTEF 420
  421 FIPQKSVRYC YLKAVAERHG DQRVYGLHYI GPVAGEVIQG FAAALKSGLT INTLINTVGI 480
  481 HPTTAEEFTR LAITKRSGLD PTPASCCS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..508] PSI-BLAST 102.0 No description for 2nvkX was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.66

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle