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Protein Overview: RhoGAP5A-PB

General Information:
Name(s) found: RhoGAP5A-PB / FBpp0070750 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene RhoGAP5A is referred to in FlyBase by the symbol Dmel\RhoGAP5A (CG3208, FBgn0029778). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:5510603..5512834. It has the cytological map location 5A8. Based on sequence similarity, it is predicted to have molecular function</span>: diacylglycerol binding. There is experimental evidence that it is involved in the biological process</span>: regulation of MAPKKK cascade; adherens junction maintenance; compound eye development; cell-cell adhesion. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 440 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEA]
    Biological Process: cell-cell adhesion [IMP]
    regulation of MAPKKK cascade [IMP]
    adherens junction maintenance [IMP]
    compound eye development [IMP]
    Molecular Function: protein binding [IEA]
    diacylglycerol binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPRNTEAGAG NANTGGSGGV GGAPEPSSPV QKVWKPELYK LQLEAPAPCP LRCQRTLPLP  60
   61 PAKSTAEAVE ANNLAGRLYG SEYHGLMGHL EAEQLLANAR DGSYFVRRSP QSDGYYTLSL 120
  121 RFNKRPKHYK LLYKPGVGHY LRGQDKRFDT VHDMVADGLI NFHMQLHASP IIQQINQQTK 180
  181 NCYQQSPYMT LNGRKLRALS NELGKAAAKE SKESPAEEKE QKQEEPPPPA VDPMPLVYEK 240
  241 PHHFKVHTFK GLNWCEFCAN FLWGFTAQGV KCEACGFVAH SKCSELVPPK CVPDLKRIRG 300
  301 VFGTDLTTMV QLEPHHQIPF VVRRCVEEVE ARGMLQEGIY RVSGFADEIE ALKLALDREG 360
  361 EKTDMSETAY GNVNVIAGTL KLYLRLLPVP LITFQAYPSF MAAGRTGKQA EQRQLMAEAV 420
  421 RRLPPAHHSC LQYMLEHLKR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..440] PSI-BLAST 54.0 Crystal Structure of the Human Beta2-Chimaerin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • Rho GTPase activator activity
    		•  3.23636074311268 bayes_pls_golite062009
  • Rac GTPase activator activity
    		•  2.60828835030444 bayes_pls_golite062009
  • binding
    		•  2.15139804299723 bayes_pls_golite062009
  • GTPase regulator activity
    		•  1.30064218544969 bayes_pls_golite062009
  • protein binding
    		•  1.29100556128076 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.27591985486748 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.17345244671832 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.08185110129009 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.814665873354198 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.812633486088277 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.777367738889091 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  0.554225907579379 bayes_pls_golite062009
  • phosphoprotein binding
    		•  0.53070890116366 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.518114087206799 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.21341810630731 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle