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View Structure Prediction Details

Protein: RhoGAP5A-PB
Organism: Drosophila melanogaster
Length: 440 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RhoGAP5A-PB.

Description E-value Query
Range
Subject
Range
gi|66797 - gi|66797|pir||TVFVG9 protein-tyrosine kinase (EC 2.7.1.112) yes - avian sarcoma virus Y73
249.0 [0..2] [438..51]

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Predicted Domain #1
Region A:
Residues: [1-440]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPRNTEAGAG NANTGGSGGV GGAPEPSSPV QKVWKPELYK LQLEAPAPCP LRCQRTLPLP  60
   61 PAKSTAEAVE ANNLAGRLYG SEYHGLMGHL EAEQLLANAR DGSYFVRRSP QSDGYYTLSL 120
  121 RFNKRPKHYK LLYKPGVGHY LRGQDKRFDT VHDMVADGLI NFHMQLHASP IIQQINQQTK 180
  181 NCYQQSPYMT LNGRKLRALS NELGKAAAKE SKESPAEEKE QKQEEPPPPA VDPMPLVYEK 240
  241 PHHFKVHTFK GLNWCEFCAN FLWGFTAQGV KCEACGFVAH SKCSELVPPK CVPDLKRIRG 300
  301 VFGTDLTTMV QLEPHHQIPF VVRRCVEEVE ARGMLQEGIY RVSGFADEIE ALKLALDREG 360
  361 EKTDMSETAY GNVNVIAGTL KLYLRLLPVP LITFQAYPSF MAAGRTGKQA EQRQLMAEAV 420
  421 RRLPPAHHSC LQYMLEHLKR 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 54.0
Match: 1xa6A
Description: Crystal Structure of the Human Beta2-Chimaerin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
Rho GTPase activator activity 3.23636074311268 bayes_pls_golite062009
Rac GTPase activator activity 2.60828835030444 bayes_pls_golite062009
binding 2.15139804299723 bayes_pls_golite062009
GTPase regulator activity 1.30064218544969 bayes_pls_golite062009
protein binding 1.29100556128076 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 1.27591985486748 bayes_pls_golite062009
molecular adaptor activity 1.17345244671832 bayes_pls_golite062009
SH3/SH2 adaptor activity 1.08185110129009 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 0.814665873354198 bayes_pls_golite062009
enzyme regulator activity 0.812633486088277 bayes_pls_golite062009
protein binding, bridging 0.777367738889091 bayes_pls_golite062009
small GTPase regulator activity 0.554225907579379 bayes_pls_golite062009
phosphoprotein binding 0.53070890116366 bayes_pls_golite062009
insulin receptor binding 0.518114087206799 bayes_pls_golite062009
insulin-like growth factor receptor binding 0.21341810630731 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle