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Protein Overview: FBpp0310168, rb-...

General Information:
Name(s) found: FBpp0310168 [FlyBase]
FBpp0304569 [FlyBase]
rb-PA / FBpp0070670 [FlyBase]
Description(s) found:
Found 32 descriptions.
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  • type=protein; loc=X:complement(4430677..4431464,4431519..4432742,4432808..4433636,4433697..4434338); ID=FBpp0310168; name=rb-PD; parent=FBgn0003210,FBtr0343568; dbxref=FlyBase:FBpp0310168,FlyBase_Annotation_IDs:CG11427-PD; MD5=5f0317aaf232ca29fa032679d341b89b; length=1160; release=r5.56; species=Dmel; [FlyBase]
  • type=protein; loc=X:complement(4430677..4431464,4431519..4432742,4432808..4433636,4433697..4434338); ID=FBpp0304569; name=rb-PC; parent=FBgn0003210,FBtr0332290; dbxref=REFSEQ:NP_001259239,GB_protein:AGB95085,FlyBase:FBpp0304569,FlyBase_Annotation_IDs:CG11427-PC; MD5=5f0317aaf232ca29fa032679d341b89b; length=1160; release=r5.56; species=Dmel; [FlyBase]
  • The gene ruby is referred to in FlyBase by the symbol Dmel\rb (CG11427, FBgn0003210). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:4429668..4434669. It has the cytological map location 4C7. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: protein binding; protein transporter activity. There is experimental evidence that it is involved in the biological process</span>: regulation of protein ubiquitination; determination of adult lifespan; ommochrome biosynthetic process. 16 alleles are reported. The phenotypes of these alleles are annotated with: Malpighian tubule; testis pigment cell; secondary pigment cell pigment granule; ocellus pigment granule; tertiary pigment cell pigment granule; photoreceptor cell pigment granule; pigment cell. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1160 amino acids

    Gene Ontology:
    Cellular Component: membrane coat [IEA]
    synaptic vesicle [TAS]
    Golgi apparatus [IEA]
    coated vesicle [TAS]
    Biological Process: vesicle coating [TAS]
    eye pigment biosynthetic process [TAS]
    lysosome organization [ISS]
    vesicle-mediated transport [NAS]
    synaptic vesicle coating [TAS]
    ommochrome biosynthetic process [IMP]
    intracellular transport [TAS]
    determination of adult lifespan [IMP]
    regulation of protein ubiquitination [IMP]
    eye pigment granule organization [NAS]
    intracellular protein transport [IEA]
    endocytosis [IEA]
    Molecular Function: protein binding [IEA]
    protein transporter activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQQNSASNPF AMSTYVERPQ MGLDVEFGAD PASGAAFFQS DGRKHDDLKQ MLDSNKDGLK  60
   61 LEAMKRIIGM IARGRDASDL FPAVVKNVVS KNIEVKKLVY VYLVRYAEEQ QDLALLSIST 120
  121 FQRALKDPNQ LIRASALRVL SSIRVSMIVP IVMLAIRDSA ADLSPYVRKT AAHAIPKLYS 180
  181 LDADQKDELV MVIEKLLSDR TTLVVGSAVM AFDEVCPERV DLIHKNYRKL CNFLLDVDEW 240
  241 GQVIIINMLT RYARTQFVDP NADDEDLVND GLGETPVSER FYDESSHSSS HSDDGSSDDE 300
  301 KNKSSTNNKN NGGGNGSRTP SSPSNSYHID VDHRLLLRQT KPLLQSRNAS VVMAVAQLYH 360
  361 HVAPKNEVQL IAKALIRLLR SHKEVQSVVL NCIASMSTKR KAIFEPHLKS FFVRTSDPTH 420
  421 IKLLKLDILT NLASAGSISL ILREFQTYIS SSDRSFVAAT IQAIGRCASS IKEVTETCLS 480
  481 GLVHLLSNHD EHVVAESVVV IKRLLQTKAA EHFEIITQMA KLIDYINVPA ARAAIIWLIG 540
  541 EYNEKVPLIA PDVLRKMAKS FVDEQDVVKL QVLNLGVKLY LTNPEQTSLL CQYVFTLARY 600
  601 DPNYDVRDRA RFLRQIIFPA SGTSSVLSQH ARQVFLASKP APVPESKYRD GNNFQLGSLS 660
  661 HYLNMPAAGY KELPAFPVIP PDSSVRNIAG FMQDKLPGED SPSGHSKDKS GREGGKEKGA 720
  721 GGEKGFLSES DDKSSAYSES GSSSGSGTSD SESDSDGSGS SDEEEEEVQK QQPTKVSSVK 780
  781 ERLIDAGSNE LAATSSPVKA TINNNNNARG SSGTSDSEDS SAYSGSSSDD SASGSDNEVK 840
  841 KNETKTDTGT KPEKLKEKHE KQPEQTAVKS NLDLLLDLDD IPPIGPVMTP SLGGFLTPGT 900
  901 PMMAGQAAPL QPQHARNRVE LVGPSHIEFK HKELLNKVSG HGLHLAYRFT RSPHLYSSSM 960
  961 CSIELQFQNR GEKEITAIRL GQTTLPAGMQ LNEFAPITVL QPQQTASGVL GVDFNDSTHA1020
 1021 VDLELLSSAG SSRLQLKPPV GELVRSVQIG ESCHREERAK LRGMNEHQCE LRGLRQDLID1080
 1081 VVALRQKVFE SINVAHTHSS SSGQLHCFAG QTLSSKSLVL LTLDWKTEDA LTLLVNCEKM1140
 1141 VIGSMVLNEL RNALQLSFAM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..692] PSI-BLAST 124.0 Adaptin beta subunit N-terminal fragment
    2 View Details [693..750] deduced N/A No confident structure predictions are available.
    3 View Details [751..921] MSA 2.369997 View MSA. No confident structure predictions are available.
    4 View Details [922..1014] PSI-BLAST 9.69897 Gamma1-adaptin domain
    5 View Details [1015..1160] FFAS03 1.6 Crystal structure of the alpha-adaptin appendage domain, from the AP2 adaptor complex, bound to 2 peptides from Synaptojanin170

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • clathrin binding
    		•  3.59686293424084 bayes_pls_golite062009
  • binding
    		•  2.6374633159018 bayes_pls_golite062009
  • protein transporter activity
    		•  1.89064797870418 bayes_pls_golite062009
  • protein binding
    		•  1.73688475473996 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.49303189891558 bayes_pls_golite062009
  • transporter activity
    		•  1.23282648733451 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.820796192007653 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.776371008347153 bayes_pls_golite062009
  • DNA binding
    		•  0.722443852840929 bayes_pls_golite062009
  • transcription factor activity
    		•  0.118119079678823 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.065389787765811 bayes_pls_golite062009
  • kinase activity
    		•  0.022490934605857 bayes_pls_golite062009
  • protein kinase activity
    		•  0.017827998785715 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • binding
    		•  1.93554535044651 bayes_pls_golite062009
  • protein binding
    		•  1.17960228368657 bayes_pls_golite062009
  • transporter activity
    		•  0.169557557237959 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.88

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle